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公开(公告)号：US20230416292A1
公开(公告)日：2023-12-28
申请号：US18036744
申请日：2021-11-30
发明人： ROLANDO ALEJANDRO GARCIA GARCIA , Joel A. SAYDOFF , David Michael SIMPSON , Reid Warren VON BORSTEL
IPC分类号： C07H19/067 , A61K9/00
CPC分类号： C07H19/067 , A61K9/0053
摘要： 5′-O-Phenylacetyluridine effectively delivers both phenylacetate and uridine to a subject. It can be used to treat hepatic encephalopathy and genetic disorders of the hepatic nitrogen cycle.
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公开(公告)号：US20230357304A1
公开(公告)日：2023-11-09
申请号：US18021907
申请日：2021-09-14
IPC分类号： C07H19/067
CPC分类号： C07H19/067
摘要： 5′-O-(Acetoacetyl)-2′,3′-di-O-acetyluridine is useful in the treatment or prevention of disorders characterized by cerebral metabolic energy failure or diminished mitochondrial energy reserve capacity.
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公开(公告)号：US20220273688A1
公开(公告)日：2022-09-01
申请号：US17667703
申请日：2022-02-09
IPC分类号： A61K31/7072 , A61K45/06 , A61K31/7008 , A61K31/7012 , A61P43/00 , A61K31/7004 , A61P21/00
摘要： Uridine triacetate or other uridine prodrugs are used to treat genetic glycosylation disorders by administering them in an amount sufficient to raise plasma uridine in the patient to a level greater than 30 micromolar. They can be administered alone or in combination with a sugar whose transfer is defective in the glycosylation disorder being treated.
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4.发明公开公开(公告)号：US20230416244A1
公开(公告)日：2023-12-28
申请号：US18037340
申请日：2021-12-09
IPC分类号： C07D471/04 , A61P17/00 , A61P35/00
CPC分类号： C07D471/04 , A61P17/00 , A61P35/00
摘要： An imidazoquinoline compound having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer is described.
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公开(公告)号：US20210163476A1
公开(公告)日：2021-06-03
申请号：US17176923
申请日：2021-02-16
发明人： David Michael SIMPSON , Dennis Bryan ZERBY , Ming LU , Reid Warren VON BORSTEL , Rui LI , Julian READING , Stephen WOLPE
IPC分类号： C07D471/04 , C07D401/12 , A01N43/50 , C07D235/08 , C07D215/44 , A61P35/00 , A61P33/02 , C07D241/44 , C07D233/60 , C07D239/42 , C07D215/42 , A61K31/44 , A61K31/4184 , A61K31/475 , A61K31/337 , A61K31/4706 , A61K31/4709 , A01N43/90 , A61K31/4965 , A01N43/60 , A01N43/54 , A61K31/437 , C07D209/12 , C07D213/74 , C07D241/20 , A61K31/555 , A61K31/517 , A61K31/4425 , A61K31/704 , C07D239/94 , C07D215/46 , A61K31/40 , A61K31/4745 , A61K31/498 , C07D215/38 , C07D213/73 , A01N43/42 , A61K31/505 , C07D215/40 , A61K31/472 , A61K31/4164
摘要： Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
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