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公开(公告)号：US09844585B2
公开(公告)日：2017-12-19
申请号：US14314119
申请日：2014-06-25
申请人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Matthews , W. Mark Saltzman , Andrew Sawyer
发明人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Matthews , W. Mark Saltzman , Andrew Sawyer
CPC分类号： A61K38/47 , A61M5/1408 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2210/0693 , C12Y302/01 , C12Y302/01035
摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain “functionalized” embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs.
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公开(公告)号：US20140371712A1
公开(公告)日：2014-12-18
申请号：US14314119
申请日：2014-06-25
申请人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Matthews , W. Mark Saltzman , Andrew Sawyer
发明人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Matthews , W. Mark Saltzman , Andrew Sawyer
CPC分类号： A61K38/47 , A61M5/1408 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2210/0693 , C12Y302/01 , C12Y302/01035
摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain “functionalized” embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs.
摘要翻译： 本发明的一个实施例涉及一种微加工的硅基对流增强递送（CED）装置。 所述装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着所述柄部的整个长度的至少一部分设置，其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口， 流体（药物）输入口。 流体输入开口可以被配置或适于连接到供给和/或输送流体的流体储存器和/或泵和/或流量计和/或阀或其它合适的控制装置或装置。 ，一种药物）到微细化装置。 该装置可以具有并排设置在装置的不同表面中的多个通道。 该装置可以是刚性的或柔性的，在这种情况下，柔性装置可以连接到生物可降解的支撑支架上，其提供足够的结构刚性以将装置插入到靶组织中。 在本发明的某些“功能化”实施例中，CED装置配备有集成电极和/或传感器（例如谷氨酸盐）以检测和传送选择性参数信息。 本发明的另一个实施方案涉及用于药物和/或其他试剂的CED方法。 该方法可以包括递送酶或其它材料以改变组织渗透性并改善药物扩散。 本发明的另一个实施方案涉及制备用于药物的CED的装置的方法。
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公开(公告)号：US08790317B2
公开(公告)日：2014-07-29
申请号：US12525393
申请日：2008-02-12
申请人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Mattews , W. Mark Saltzman , Andrew Sawyer
发明人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Mattews , W. Mark Saltzman , Andrew Sawyer
IPC分类号： A61M5/00
CPC分类号： A61K38/47 , A61M5/1408 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2210/0693 , C12Y302/01 , C12Y302/01035
摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.
摘要翻译： 本发明的一个实施例涉及一种微加工的硅基对流增强递送（CED）装置。 所述装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着所述柄部的整个长度的至少一部分设置，其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口， 流体（药物）输入口。 流体输入开口可以被配置或适于连接到供给和/或输送流体的流体储存器和/或泵和/或流量计和/或阀或其它合适的控制装置或装置。 ，一种药物）到微细化装置。 该装置可以具有并排设置在装置的不同表面中的多个通道。
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公开(公告)号：US20100098767A1
公开(公告)日：2010-04-22
申请号：US12525393
申请日：2008-02-12
申请人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Mattews , Mark W. Saltzman , Andrew Sawyer
发明人： William L. Olbricht , Keith B. Neeves , Conor Foley , Russell T. Mattews , Mark W. Saltzman , Andrew Sawyer
CPC分类号： A61K38/47 , A61M5/1408 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2210/0693 , C12Y302/01 , C12Y302/01035
摘要： An embodiment of the invention is directed to a microfabrπcated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the device
摘要翻译： 本发明的一个实施方案涉及微加工和硅基对流增强递送（CED）装置。该装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着整个长度的至少一部分设置 其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口，以及流体（药物）输入开口。所述流体输入开口可以被配置或适于连接到流体储存器和/或 泵和/或计量器和/或阀或其他合适的控制装置或装置，其将微流体（例如药物）供应和/或输送到微加工装置。该装置可以具有并排设置的多个通道， 在设备的不同表面
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