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    CONVECTION ENHANCED DELIVERY APPARATUS, METHOD, AND APPLICATION
    1.
    发明申请
    CONVECTION ENHANCED DELIVERY APPARATUS, METHOD, AND APPLICATION 有权
    对流增强装置，方法和应用

    公开(公告)号：US20100098767A1

    公开(公告)日：2010-04-22

    申请号：US12525393

    申请日：2008-02-12

    申请人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Mattews ,  Mark W. Saltzman ,  Andrew Sawyer

    发明人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Mattews ,  Mark W. Saltzman ,  Andrew Sawyer

    IPC分类号： A61K9/14 ,  C12N9/96 ,  A61K38/44

    CPC分类号： A61K38/47 ,  A61M5/1408 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2210/0693 ,  C12Y302/01 ,  C12Y302/01035

    摘要： An embodiment of the invention is directed to a microfabrπcated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the device

    摘要翻译： 本发明的一个实施方案涉及微加工和硅基对流增强递送（CED）装置。该装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着整个长度的至少一部分设置 其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口，以及流体（药物）输入开口。所述流体输入开口可以被配置或适于连接到流体储存器和/或 泵和/或计量器和/或阀或其他合适的控制装置或装置，其将微流体（例如药物）供应和/或输送到微加工装置。该装置可以具有并排设置的多个通道， 在设备的不同表面

    Convection enhanced delivery apparatus, method, and application
    2.
    发明授权
    Convection enhanced delivery apparatus, method, and application 有权
    对流增强输送装置，方法和应用

    公开(公告)号：US08790317B2

    公开(公告)日：2014-07-29

    申请号：US12525393

    申请日：2008-02-12

    申请人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Mattews ,  W. Mark Saltzman ,  Andrew Sawyer

    发明人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Mattews ,  W. Mark Saltzman ,  Andrew Sawyer

    IPC分类号： A61M5/00

    CPC分类号： A61K38/47 ,  A61M5/1408 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2210/0693 ,  C12Y302/01 ,  C12Y302/01035

    摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.

    摘要翻译： 本发明的一个实施例涉及一种微加工的硅基对流增强递送（CED）装置。 所述装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着所述柄部的整个长度的至少一部分设置，其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口， 流体（药物）输入口。 流体输入开口可以被配置或适于连接到供给和/或输送流体的流体储存器和/或泵和/或流量计和/或阀或其它合适的控制装置或装置。 ，一种药物）到微细化装置。 该装置可以具有并排设置在装置的不同表面中的多个通道。

    Convection enhanced delivery apparatus, method, and application
    3.
    发明授权
    Convection enhanced delivery apparatus, method, and application 有权

    公开(公告)号：US09844585B2

    公开(公告)日：2017-12-19

    申请号：US14314119

    申请日：2014-06-25

    申请人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Matthews ,  W. Mark Saltzman ,  Andrew Sawyer

    发明人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Matthews ,  W. Mark Saltzman ,  Andrew Sawyer

    IPC分类号： A61M37/00 ,  A61K38/47 ,  A61M5/14

    CPC分类号： A61K38/47 ,  A61M5/1408 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2210/0693 ,  C12Y302/01 ,  C12Y302/01035

    摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain “functionalized” embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs.

    CONVECTION ENHANCED DELIVERY APPARATUS, METHOD, AND APPLICATION
    4.
    发明申请
    CONVECTION ENHANCED DELIVERY APPARATUS, METHOD, AND APPLICATION 有权
    对流增强装置，方法和应用

    公开(公告)号：US20140371712A1

    公开(公告)日：2014-12-18

    申请号：US14314119

    申请日：2014-06-25

    申请人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Matthews ,  W. Mark Saltzman ,  Andrew Sawyer

    发明人： William L. Olbricht ,  Keith B. Neeves ,  Conor Foley ,  Russell T. Matthews ,  W. Mark Saltzman ,  Andrew Sawyer

    IPC分类号： A61K38/47 ,  A61M5/14 ,  A61M37/00

    CPC分类号： A61K38/47 ,  A61M5/1408 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2210/0693 ,  C12Y302/01 ,  C12Y302/01035

    摘要： An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain “functionalized” embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs.

    摘要翻译： 本发明的一个实施例涉及一种微加工的硅基对流增强递送（CED）装置。 所述装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着所述柄部的整个长度的至少一部分设置，其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口， 流体（药物）输入口。 流体输入开口可以被配置或适于连接到供给和/或输送流体的流体储存器和/或泵和/或流量计和/或阀或其它合适的控制装置或装置。 ，一种药物）到微细化装置。 该装置可以具有并排设置在装置的不同表面中的多个通道。 该装置可以是刚性的或柔性的，在这种情况下，柔性装置可以连接到生物可降解的支撑支架上，其提供足够的结构刚性以将装置插入到靶组织中。 在本发明的某些“功能化”实施例中，CED装置配备有集成电极和/或传感器（例如谷氨酸盐）以检测和传送选择性参数信息。 本发明的另一个实施方案涉及用于药物和/或其他试剂的CED方法。 该方法可以包括递送酶或其它材料以改变组织渗透性并改善药物扩散。 本发明的另一个实施方案涉及制备用于药物的CED的装置的方法。

    Apparatus, system, and computer program for synchronizing communications
    5.
    发明授权
    Apparatus, system, and computer program for synchronizing communications 有权
    用于同步通信的设备，系统和计算机程序

    公开(公告)号：US08068448B1

    公开(公告)日：2011-11-29

    申请号：US11764004

    申请日：2007-06-15

    申请人： Conor Foley ,  Venugopal Eyyunni

    发明人： Conor Foley ,  Venugopal Eyyunni

    IPC分类号： H04B7/22

    CPC分类号： H04B7/18515

    摘要： A satellite communication system includes a hub, a repeater, a scheduling unit, and a remote. The scheduling unit is configured to synchronize a communication of the system based on an elapsed time between (i) an arrival at the remote of a downstream reference frame transmitted by the hub and retransmitted by the repeater, and (ii) an arrival at the remote of an upstream frame transmitted by the remote and retransmitted by the repeater.

    摘要翻译： 卫星通信系统包括集线器，中继器，调度单元和远程设备。 调度单元被配置为基于在（i）到达由集线器发送的和由中继器重传的下游参考帧的远程之间的经过时间，以及（ii）到达远程 由远端发送并由中继器重发的上行帧。

    Method to eliminate frequency offset introduced in a network
    6.
    发明授权
    Method to eliminate frequency offset introduced in a network 有权
    消除网络中引入频偏的方法

    公开(公告)号：US08027285B1

    公开(公告)日：2011-09-27

    申请号：US11763986

    申请日：2007-06-15

    申请人： Venugopal Eyyunni ,  Christopher Donald Gregory ,  Conor Foley

    发明人： Venugopal Eyyunni ,  Christopher Donald Gregory ,  Conor Foley

    IPC分类号： H04B7/14

    CPC分类号： H04B7/18515

    摘要： A remote, a communications system, and a method in which the remote communicates with another remote via a repeater and also communicates with a hub. The remote includes a transceiver configured to receive a signal from the another remote, a measuring unit configured to measure a first offset, and a calculation unit configured to calculate a frequency offset for the signal based on (i) the first offset measured at the measuring unit, and (ii) a second offset measured at the hub.

    摘要翻译： 遥控器，通信系统和远程通过中继器与另一个远程通信并且还与集线器通信的方法。 遥控器包括收发器，其被配置为从另一遥控器接收信号，被配置为测量第一偏移的测量单元和被配置为基于（i）在测量时测量的第一偏移来计算信号的频率偏移的计算单元 单位，和（ii）在集线器处测量的第二偏移。

    Adjusting transmission power under changing conditions
    8.
    发明授权
    Adjusting transmission power under changing conditions 有权
    在变化的条件下调整发射功率

    公开(公告)号：US08094606B1

    公开(公告)日：2012-01-10

    申请号：US11764020

    申请日：2007-06-15

    申请人： Conor Foley ,  Christopher Donald Gregory ,  Sang Ho Go ,  Venugopal Eyyunni

    发明人： Conor Foley ,  Christopher Donald Gregory ,  Sang Ho Go ,  Venugopal Eyyunni

    IPC分类号： H04B7/185

    CPC分类号： H04B7/15535

    摘要： A communication system includes a hub, a repeater, and a remote. The hub is configured to adjust a transmission power of the remote depending on an external condition based on (i) a measured carrier-to-noise ratio CNHubsignal1 of data transmitted from the hub to the repeater and back to the hub using a first signal, (ii) a measured carrier-to-noise ratio CNHubsignal2 of data transmitted from the remote to the hub via the repeater using a second signal, (iii) a predetermined carrier-to-noise ratio CNHubSCPCCS of data transmitted from the hub to the repeater and back to the hub using the first signal under a clear sky condition, and (iv) a predetermined carrier-to-noise ratio CNHubTDMACS of data transmitted from a reference remote to the repeater and back to the hub using the second signal under a clear sky condition.

    摘要翻译： 通信系统包括集线器，中继器和远程设备。 集线器被配置为基于（i）使用第一信号从集线器发送到中继器并返回到集线器的数据的测量的载波信噪比CNHubsignal1来调整根据外部条件的远程的发射功率， （ii）经由中继器使用第二信号从远端发送到集线器的数据的测量的载波信噪比CNHubsignal2，（iii）从集线器向中继器发送的数据的预定的载波信噪比CNHubSCPCCS 并且在晴空条件下使用第一信号返回到集线器，以及（iv）从参考远程到中继器发送的数据的预定载波噪声比CNHubTDMACS，并且使用第二信号在清楚的情况下返回到集线器 天空条件

    Method, apparatus, and system for calculating and making a synchronous burst time plan in a communication network
    9.
    发明授权
    Method, apparatus, and system for calculating and making a synchronous burst time plan in a communication network 有权
    在通信网络中计算和制作同步突发时间计划的方法，装置和系统

    公开(公告)号：US07215652B1

    公开(公告)日：2007-05-08

    申请号：US10721419

    申请日：2003-11-26

    申请人： Conor Foley ,  David D. Bettinger

    发明人： Conor Foley ,  David D. Bettinger

    IPC分类号： H04B7/204 ,  H04B7/185 ,  H04B7/212

    CPC分类号： H04B7/212

    摘要： A communication network control method for a communication network including a hub and a plurality of user nodes includes adjusting system parameters to maximize communication data rate and minimize bit error rate given current conditions of the wireless channel, current loading of the network, and user constraints. In particular, the method includes transmitting a first and second frame with first and second control information from the hub to each user node, and transmitting a first and second data burst from each of the user nodes to the hub according to the first and second control information. The start of the time frame of the data burst from each user node arrives simultaneously at the hub. Further, the time frame of the second data burst from each user node arrives immediately following the arrival of the time frame of the first data burst.

    摘要翻译： 包括集线器和多个用户节点的通信网络的通信网络控制方法包括调整系统参数以最大化通信数据速率并且最小化给定当前无线信道条件，网络的当前负载和用户约束的误码率。 具体地说，该方法包括：将来自集线器的第一和第二控制信息的第一和第二帧传输到每个用户节点，以及根据第一和第二控制将来自每个用户节点的第一和第二数据突发传送到集线器 信息。 来自每个用户节点的数据突发的时间帧的开始同时到达集线器。 此外，来自每个用户节点的第二数据突发的时间帧在第一数据突发的时间帧到达之后立即到达。

    Method, apparatus, and system for using a synchronous burst time plan in a communication network
    10.
    发明授权
    Method, apparatus, and system for using a synchronous burst time plan in a communication network 有权
    在通信网络中使用同步突发时间计划的方法，装置和系统

    公开(公告)号：US07257371B1

    公开(公告)日：2007-08-14

    申请号：US10721497

    申请日：2003-11-26

    申请人： David D. Bettinger ,  Joseph J. Boone ,  Hao Cheng ,  David B. S. Edsberg ,  Venugopal Eyyunni ,  Conor Foley ,  Christopher D. Gregory ,  Jason B. Maiorana

    发明人： David D. Bettinger ,  Joseph J. Boone ,  Hao Cheng ,  David B. S. Edsberg ,  Venugopal Eyyunni ,  Conor Foley ,  Christopher D. Gregory ,  Jason B. Maiorana

    IPC分类号： H04B7/19 ,  H04J3/06

    CPC分类号： H04B7/2125

    摘要： A communication network control method for a communication network including a hub and a plurality of user nodes includes adjusting system parameters to maximize communication data rate and minimize bit error rate given current conditions of the wireless channel, current loading of the network, and user constraints. In particular, the method includes transmitting a first and second frame with first and second control information from the hub to each user node, and transmitting a first and second respective data burst from each of the user nodes to the hub according to the first and second control information. The first data burst from each user node arrives simultaneously at the hub, and the second data burst from each user node arrives simultaneously at the hub. Further, the second data burst from each user node arrives immediately following the arrival of the first data burst from each user node.

    摘要翻译： 包括集线器和多个用户节点的通信网络的通信网络控制方法包括调整系统参数以最大化通信数据速率并且最小化给定当前无线信道条件，网络的当前负载和用户约束的误码率。 具体地说，该方法包括：将来自集线器的第一和第二控制信息的第一和第二帧传送到每个用户节点，以及根据第一和第二传输从每个用户节点向集线器发送第一和第二相应的数据脉冲串 控制信息。 来自每个用户节点的第一数据突发同时到达集线器，并且来自每个用户节点的第二数据突发同时到达集线器。 此外，来自每个用户节点的第二数据脉冲串在从每个用户节点到达第一数据脉冲串之后立即到达。