公开(公告)号：US20240315192A1

公开(公告)日：2024-09-26

申请号：US18735258

申请日：2024-06-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN ,  Adam JOZWIAK

IPC: A01H6/82 ,  C12N9/10 ,  C12N15/82

CPC classification number: A01H6/82 ,  C12N9/1059 ,  C12N15/8218 ,  C12N15/8243 ,  C12N15/8247

Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

公开(公告)号：US20240150744A1

公开(公告)日：2024-05-09

申请号：US18281341

申请日：2022-03-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Adam JOZWIAK ,  Paula BERMAN ,  Luis DE-HARO

IPC: C12N9/00 ,  C12N15/82 ,  C12P17/18

CPC classification number: C12N9/93 ,  C12N15/8243 ,  C12P17/182

Abstract: The present invention provides polynucleotide sequences derived from Helichrysum umbraculigerum and encoding a protein or a plurality thereof belonging to the acyl activating enzyme (AAE) family. Further provided are an artificial nucleic acid molecule including the polynucleotide, a transgenic cell, tissue, or plant including same. Further provided are method for synthesizing an acyl coenzyme A (CoA).

公开(公告)号：US20240182873A1

公开(公告)日：2024-06-06

申请号：US18281536

申请日：2022-03-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Adam JOZWIAK ,  Paula BERMAN ,  Luis DE-HARO

IPC: C12N9/10 ,  C12P7/42

CPC classification number: C12N9/1085 ,  C12P7/42

Abstract: The present invention provides polynucleotide sequences derived from Helichrysum umbraculigerum and encoding a protein or a plurality thereof belonging to the prenyltransferase (PT) family. Further provided are an artificial nucleic acid molecule including the polynucleotide, a transgenic cell, tissue, or plant including same.