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    Cellulose-synthase-like enzymes and uses thereof
    2.
    发明授权
    Cellulose-synthase-like enzymes and uses thereof 有权

    公开(公告)号：US12041907B2

    公开(公告)日：2024-07-23

    申请号：US17272685

    申请日：2019-09-05

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph Aharoni ,  Prashant Sonawane ,  Maxim Itkin ,  Adam Jozwiak

    IPC: A01H6/82 ,  C12N9/10 ,  C12N15/82

    CPC classification number: A01H6/82 ,  C12N9/1059 ,  C12N15/8218 ,  C12N15/8243 ,  C12N15/8247

    Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

    Plant with altered content of steroidal alkaloids
    3.
    发明授权
    Plant with altered content of steroidal alkaloids 有权

    公开(公告)号：US11412700B2

    公开(公告)日：2022-08-16

    申请号：US17008875

    申请日：2020-09-01

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph Aharoni ,  Prashant Sonawane ,  Maxim Itkin

    IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

    Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.

    Plant with altered content of steroidal alkaloids
    4.
    发明授权
    Plant with altered content of steroidal alkaloids 有权

    公开(公告)号：US10806119B2

    公开(公告)日：2020-10-20

    申请号：US16123248

    申请日：2018-09-06

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

    Inventor： Asaph Aharoni ,  Prashant Sonawane ,  Maxim Itkin

    IPC: C12N15/82 ,  A01H6/82 ,  A01H5/10 ,  C12N9/10

    Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.

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