利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

120 条记录 (耗时 0.034 秒)

    Compounds and methods for diagnosis and treatment of leishmaniasis
    1.
    发明授权
    Compounds and methods for diagnosis and treatment of leishmaniasis 有权
    利什曼病诊断和治疗的化合物和方法

    公开(公告)号：US08865180B2

    公开(公告)日：2014-10-21

    申请号：US12901961

    申请日：2010-10-11

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K39/00 ,  A61K39/02 ,  G01N33/50 ,  G01N33/569 ,  G01N33/68

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS
    2.
    发明申请
    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS 有权
    用于诊断和治疗感染的化合物和方法

    公开(公告)号：US20110280902A1

    公开(公告)日：2011-11-17

    申请号：US12901961

    申请日：2010-10-11

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K38/17 ,  A61P37/02 ,  A61P33/02 ,  A61K38/10 ,  C07K14/435 ,  C40B60/12

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Compounds and methods for diagnosis and treatment of leishmaniasis
    5.
    发明授权
    Compounds and methods for diagnosis and treatment of leishmaniasis 有权
    利什曼病诊断和治疗的化合物和方法

    公开(公告)号：US07833534B2

    公开(公告)日：2010-11-16

    申请号：US11733440

    申请日：2007-04-10

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K39/02 ,  A61K49/00 ,  A61N63/00

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Recombinant Polyprotein Vaccines For the Treatment and Diagnosis of Leishmaniasis
    6.
    发明申请
    Recombinant Polyprotein Vaccines For the Treatment and Diagnosis of Leishmaniasis 有权
    重组多蛋白疫苗用于治疗和诊断利什曼病

    公开(公告)号：US20130177584A1

    公开(公告)日：2013-07-11

    申请号：US13794903

    申请日：2013-03-12

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K39/008

    CPC分类号： A61K39/008 ,  A61K2039/552 ,  A61K2039/55572 ,  C07K14/44 ,  C12N15/62

    摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.

    摘要翻译： 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含包含多个利什曼原虫抗原，特别是KMP11，SMT，A2和/或CBP或其免疫原性部分或变体，以及编码这种融合多肽的多核苷酸的融合多肽。