公开(公告)号：US20040142860A1

公开(公告)日：2004-07-22

申请号：US09814699

申请日：2001-03-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Pierre Beserman ,  David L. Hirschberg

IPC: A61K038/17 ,  C07K014/74

CPC classification number: C07K5/06104 ,  A61K38/00 ,  C07K4/12 ,  Y02A50/465

Abstract: The present invention is directed to a central nervous system-derived heat stable immune privilege factor which exerts an inhibitory effect on macrophage migration and/or macrophage phagocytic activity. In addition, the factor exerts an inhibitory effect on the ability of macrophages and T cells to adhere to extracellular matrix and/or fibronectin. The invention is also directed to the isolation and methods for use of this immune privilege factor for the inhibition of inflammation in the central nervous system generally and at specific lesions in the central nervous system.

Abstract translation: 本发明涉及对巨噬细胞迁移和/或巨噬细胞吞噬活性具有抑制作用的中枢神经系统衍生的热稳定免疫特异性因子。 此外，该因子对巨噬细胞和T细胞粘附于细胞外基质和/或纤连蛋白的能力产生抑制作用。 本发明还涉及使用这种免疫特权因子来抑制中枢神经系统中的中枢神经系统炎症和中枢神经系统特定病变的分离和方法。

公开(公告)号：US20020072493A1

公开(公告)日：2002-06-13

申请号：US09893348

申请日：2001-06-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ehud Hauben ,  Irun R. Cohen ,  Pierre Beserman ,  Alon Mosonego ,  Gila Moalem

IPC: A61K038/17

CPC classification number: A61K38/1709 ,  A61K39/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/5158 ,  C07K14/47 ,  C07K14/705

Abstract: Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, eiteher the central nervous system or the peripheral nervous system, are provided. Treatment involves administering NS-specific activated T cells, or an NS-specific antigen or analog thereof, a peptide derived therefrom or an analog or derivative of said peptide, or a nucleotide sequence encoding said antigen or peptide, or any combination thereof.

Abstract translation: 提供了促进神经再生或赋予神经保护作用并预防或抑制神经系统内神经元变性，中枢神经系统或周围神经系统的组合物和方法。 治疗涉及施用NS-特异性活化T细胞或NS-特异性抗原或其类似物，从其衍生的肽或所述肽的类似物或衍生物，或编码所述抗原或肽的核苷酸序列或其任何组合。

公开(公告)号：US20040253218A1

公开(公告)日：2004-12-16

申请号：US10810653

申请日：2004-03-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Michal Eisenbach-Schwartz ,  Ester Yoles ,  Ehud Hauben ,  Irun R. Cohen ,  Pierre Beserman ,  Alon Monsonego ,  Gila Moalem

IPC: A61K045/00 ,  A61K038/17

CPC classification number: A61K38/1709 ,  A61K39/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/5158 ,  C07K14/47 ,  C07K14/705

Abstract: Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, either the central nervous system or the peripheral nervous system, are provided. Treatment involves administering NS-specific activated T cells, or an NS-specific antigen or analog thereof, a peptide derived therefrom or an analog or derivative of said peptide, or a nucleotide sequence encoding said antigen or peptide, or any combination thereof.