公开(公告)号：US20250114788A1

公开(公告)日：2025-04-10

申请号：US18981736

申请日：2024-12-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Alexandra TAYAR ,  Shirley SHULMAN DAUBE ,  Yuval EFRATH ,  Michael LEVY

IPC: B01L3/00 ,  C12N13/00 ,  C12N15/10 ,  G01N27/447

Abstract: Methods of controlling biological processes by altering the electric field gradient in a test chamber are disclosed. A portion of a surface of the test chamber is attached to at least one immobilized component of the biological process. Microfluidic devices capable of same are also disclosed.

公开(公告)号：US20220314221A1

公开(公告)日：2022-10-06

申请号：US17839667

申请日：2022-06-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Eyal KARZBRUN ,  Alexandra TAYAR

IPC: B01L3/00 ,  C12P21/02 ,  B01J19/00

Abstract: A microfluidic device is disclosed which comprises: (i) at least one reaction unit having a test chamber connected to at least one microchannel, wherein a surface of at least a portion of said reaction unit is attached to an isolated nucleic acid; and (ii) a flow-through channel having at least one inlet port and at least one outlet port, said flow-through channel and said microchannel being of dimensions to allow reactant diffusion to and from said reaction unit, wherein the diffusion time of said reactant along the microchannel is shorter than the flow time along the microchannel.

公开(公告)号：US20220213467A1

公开(公告)日：2022-07-07

申请号：US17702880

申请日：2022-03-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Shirley SHULMAN DAUBE ,  Michael LEVY ,  Reuven FALKOVICH ,  Ohad VONSHAK ,  Yiftach DIVON

IPC: C12N15/10 ,  G01N33/543

Abstract: A method of assembling and immobilizing proteinaceous complexes is disclosed. In addition, methods of generating functional RNA polymerase and ribosomal subunits are disclosed.

公开(公告)号：US20210031193A1

公开(公告)日：2021-02-04

申请号：US17029228

申请日：2020-09-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Alexandra TAYAR ,  Shirley SHULMAN DAUBE ,  Yuval EFRATH ,  Michael LEVY

IPC: B01L3/00 ,  C12N15/10 ,  C12N13/00 ,  G01N27/447

Abstract: Methods of controlling biological processes by altering the electric field gradient in a test chamber are disclosed. A portion of a surface of the test chamber is attached to at least one immobilized component of the biological process. Microfluidic devices capable of same are also disclosed.

公开(公告)号：US20160243547A1

公开(公告)日：2016-08-25

申请号：US15027471

申请日：2014-10-07

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Roy BAR-ZIV ,  Eyal KARZBRUN ,  Alexandra TAYAR

IPC: B01L3/00 ,  B01J19/00 ,  C12P21/02

CPC classification number: B01L3/502715 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0694 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0472 ,  B01L2400/0487 ,  B01L2400/06 ,  C12P21/02 ,  C12Q2565/629

Abstract: A microfluidic device is disclosed which comprises: (i) at least one reaction unit having a test chamber connected to at least one microchannel, wherein a surface of at least a portion of said reaction unit is attached to an isolated nucleic acid; and (ii) a flow-through channel having at least one inlet port and at least one outlet port, said flow-through channel and said microchannel being of dimensions to allow reactant diffusion to and from said reaction unit, wherein the diffusion time of said reactant along the microchannel is shorter than the flow time along the microchannel.

Abstract translation: 公开了一种微流体装置，其包括：（i）至少一个具有连接至少一个微通道的测试室的反应单元，其中所述反应单元的至少一部分的表面连接到分离的核酸上; 和（ii）具有至少一个入口和至少一个出口的流通通道，所述流通通道和所述微通道具有允许反应物向所述反应单元扩散的尺寸，其中所述 沿着微通道的反应物比沿着微通道的流动时间短。