公开(公告)号：US20240342708A1

公开(公告)日：2024-10-17

申请号：US18610057

申请日：2024-03-19

申请人： National Research Council of Canada

发明人： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC分类号： B01L3/00 ,  G01N21/552 ,  G01N33/543

CPC分类号： B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/502792 ,  G01N21/554 ,  G01N33/54386 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N2201/023 ,  G01N2201/061

摘要： A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US12112941B2

公开(公告)日：2024-10-08

申请号：US17764223

申请日：2020-08-31

申请人： THE INDUSTRY & ACADEMIC COOPERPATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)

发明人： Seong Min Kang ,  Ji Seong Choi

IPC分类号： H01L21/02 ,  B01L3/00 ,  C23C16/40 ,  H01L21/027 ,  H01L21/3065 ,  H01L21/311 ,  H01L21/3205 ,  H01L21/3213

CPC分类号： H01L21/0212 ,  B01L3/502707 ,  B01L3/502746 ,  C23C16/402 ,  H01L21/02164 ,  H01L21/02274 ,  H01L21/0273 ,  H01L21/3065 ,  H01L21/31116 ,  H01L21/32055 ,  H01L21/32137 ,  B01L2300/12 ,  B01L2300/166 ,  B01L2400/088

摘要： A selective liquid sliding surface includes: a base layer; multiple pillars protruding from the base layer; and a head protruding from an upper surface of each of the multiple pillars and having a larger cross-sectional diameter than the pillar, wherein the head includes a first head protruding from the pillar and a second head protruding from a periphery of the first head, and the base layer, the pillar, and the head are formed of the same material.

公开(公告)号：US20240293817A1

公开(公告)日：2024-09-05

申请号：US18655434

申请日：2024-05-06

申请人： Xilis, Inc.

发明人： Bradley Scott Thomas ,  Timothy A. Miller ,  David Stafford

IPC分类号： B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M3/06 ,  G01N15/14 ,  G01N15/1433 ,  G01N15/1434

CPC分类号： B01L3/502784 ,  B01L3/50273 ,  B01L3/502746 ,  C12M23/16 ,  C12M23/40 ,  C12M25/16 ,  C12M41/12 ,  C12M41/36 ,  C12M41/40 ,  G01N15/1433 ,  G01N15/1434 ,  G01N15/1459 ,  B01L2200/061 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/161 ,  B01L2300/1805 ,  B01L2400/082 ,  G01N2015/1493

摘要： A method includes flowing a first fluid through a first channel of a microfluidic apparatus and flowing a second fluid through a second channel of the microfluidic apparatus. The first fluid comprises biological material and a matrix material and is immiscible with the second fluid. The first and second fluids are combined at a junction to form droplets of the first fluid dispersed in the second fluid in a third channel. Multiple exposures of a droplet in the third channel are captured in a single image, comprising: illuminating a region of the third channel with multiple successive illumination pulses during a single frame of the imaging device; identifying the droplet and determining a velocity or a size of the droplet based on an analysis of the captured exposures; and controlling the flow of the first fluid or second fluid to obtain droplets of a target size or velocity.

公开(公告)号：US12036553B2

公开(公告)日：2024-07-16

申请号：US17418852

申请日：2019-05-03

申请人： MIKRO BIYOSISTEMLER ELEKTRONIK SANAYI VE TICARET A.S.

发明人： Gurhan Ozkayar ,  Ender Yildirim ,  Ozge Zorlu

IPC分类号： B01L3/00 ,  G01N15/10

CPC分类号： B01L3/502761 ,  B01L3/502746 ,  G01N15/10 ,  B01L2200/0652 ,  B01L2300/0883 ,  B01L2400/086 ,  G01N2015/1028

摘要： A method and a device for a microfluidic separation enhancement according to size of the particles to be separated are provided. An asymmetric obstacle in a shape of a cambered hydrofoil, placed at a downstream of a microfluidic channel increases a distance between particles of different sizes, wherein the particles have been partially separated at an upstream of the microfluidic channel, resulting an enhancement in the separation efficiency. Thus, microchannel length is decreased, resulting a decrease in hydraulic resistance and footprint of the microchannel.

公开(公告)号：US20240198339A1

公开(公告)日：2024-06-20

申请号：US18595927

申请日：2024-03-05

申请人： The General Hospital Corporation

发明人： Ravi Kapur ,  Kyle C. Smith ,  Mehmet Toner

IPC分类号： B01L3/00 ,  A61K35/28 ,  G01N1/40 ,  G01N15/00 ,  G01N15/01 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14 ,  G01N15/149

CPC分类号： B01L3/502761 ,  A61K35/28 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  G01N1/4077 ,  G01N15/0255 ,  G01N15/0618 ,  G01N15/1484 ,  B01L3/502776 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0877 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N2001/4088 ,  G01N2015/0053 ,  G01N15/01 ,  G01N2015/0288 ,  G01N2015/1486 ,  G01N15/149 ,  G01N2015/1493

摘要： A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

公开(公告)号：US20240183270A1

公开(公告)日：2024-06-06

申请号：US18338767

申请日：2023-07-28

申请人： CHINA UNIVERSITY OF PETROLEUM (EAST CHINA)

发明人： Jian Hou ,  Bei Wei ,  Yongsheng Liu ,  Kang Zhou ,  Qingjun Du ,  Yongge Liu ,  Ermeng Zhao ,  Dejun Wu

IPC分类号： E21B49/00 ,  B01L3/00

CPC分类号： E21B49/008 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/143

摘要： A gel particle-containing discontinuous phase seepage experimental apparatus includes a micro-liquid volume injection system, a pressure acquisition and transmission system, a microscopic observation system, and an in-microchannel particle screening and transfer system. According to the established discontinuous phase seepage experimental apparatus, particle sizes of gel particles are accurately screened by using a customized microfluidic chip, and transfer forms, existing states, pressure fluctuations, and the like of gel particles in a single-channel microfluidic chip under the conditions of different sizes, different elastic modulus, and different quantities are monitored in real-time by using a high-precision pressure sensing system and a microscopic observation system.

公开(公告)号：US11992841B2

公开(公告)日：2024-05-28

申请号：US17466430

申请日：2021-09-03

申请人： SHIMADZU CORPORATION

发明人： Ippei Takeuchi

IPC分类号： B01L3/00

CPC分类号： B01L3/502746 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/04 ,  B01L2300/069 ,  B01L2300/0883 ,  B01L2400/0487

摘要： A test apparatus for a test using a test solution containing a sample with the use of a microchannel device is provided. The test apparatus includes a pressure application unit that is connected to a first opening and applies an air pressure to inject the test solution into a microchannel, an opening and closing unit that switches between opening and closing of a second opening, and a controller that controls the pressure application unit and the opening and closing unit. The controller controls the opening and closing unit to close the second opening, controls the pressure application unit to inject the test solution into the microchannel, controls the opening and closing unit to open the second opening after the test solution is injected into the microchannel, and controls the pressure application unit to apply an air pressure to collect in a collection portion, the test solution in a branch channel.

公开(公告)号：US11982611B2

公开(公告)日：2024-05-14

申请号：US16495738

申请日：2018-03-20

申请人： NANOCELLECT BIOMEDICAL, INC.

发明人： Sunghwan Cho ,  Jose Manuel Morachis ,  Ivan Gagne ,  Rick Segil ,  William Arthur Alaynick ,  Zhe Mei ,  Sean Phillips ,  Chien-Chun Yang ,  Dongseob Yun ,  Michael Jerome Benchimol ,  Manna Doud ,  Nicholas Sullivan ,  Constance Ardila

IPC分类号： B01L3/00 ,  B07C5/342 ,  G01N15/14 ,  G01N15/10 ,  G01N15/149

CPC分类号： G01N15/1425 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  B07C5/342 ,  G01N15/1484 ,  B01L2200/0652 ,  B01L2300/0819 ,  B01L2400/082 ,  G01N2015/1006 ,  G01N15/149

摘要： A method includes providing a cartridge and the cartridge includes a slot for receiving a microfluidic chip having a set of first channels. The cartridge also includes a set of second channels and each channel of the set of second channels is coupleable to a different channel of the set of first channels during use with the microfluidic chip. The cartridge also includes an indent configured for engagement and alignment of the cartridge during use. The method also includes inserting the cartridge into a device, such that the cartridge engages a first biasing member of the device configured for alignment of the cartridge in a first direction. The first biasing member is configured to bias movement of the cartridge into locking position with a notch of the device.

公开(公告)号：US20240149266A1

公开(公告)日：2024-05-09

申请号：US18500421

申请日：2023-11-02

申请人： Nucleic Sensing Systems, LLC

发明人： Cody Youngbull ,  Andrew Hatch

IPC分类号： B01L3/00

CPC分类号： B01L3/502746 ,  B01L2300/023 ,  B01L2300/0654

摘要： Systems, methods, and apparatuses for the detection of changes within a fluid composition while it flows in a channel. Microfluidics devices can include a detector that may include a tunable offset mechanism. The detectors can work in conjunction with an energy source that passes energy through the flow channel and into the detectors.

公开(公告)号：US20240139739A1

公开(公告)日：2024-05-02

申请号：US18278365

申请日：2021-02-26

申请人： Hewlett-Packard Development Company, L.P.

发明人： Milo OVERBAY ,  Viktor SHKOLNIKOV ,  Roberto A. PUGLIESE

IPC分类号： B01L3/00

CPC分类号： B01L3/502746 ,  B01L3/502715 ,  B01L2200/0663 ,  B01L2400/086

摘要： An example apparatus comprises includes a first reservoir to store a biologic sample containing a cell, a microfluidic channel fluidically coupled to the first reservoir, and circuitry. The microfluidic channel includes a constriction region including a first circumference that is attenuated from remaining portions of the microfluidic channel, and a fluidic pump disposed within the microfluidic channel. The circuitry is to activate the fluidic pump to direct flow of the cell from the first reservoir to the microfluidic channel and through the constriction region.