公开(公告)号：US20150265210A1

公开(公告)日：2015-09-24

申请号：US14726629

申请日：2015-06-01

Applicant: Yeda Research and Development Co. Ltd.

Inventor： David ISRAELI ,  Yael Mardor ,  Talila Volk

IPC: A61B5/00 ,  A61N2/00 ,  G01R33/56 ,  A61B5/055

CPC classification number: A61B5/4848 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4836 ,  A61B5/743 ,  A61B2576/026 ,  A61K49/0004 ,  A61N2/006 ,  G01R33/5601 ,  G01R33/56366

Abstract: A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.

Abstract translation: 公开了分析对象的血脑屏障的方法。 向对象施用可检测剂量的MRI造影剂，并且在预定时间段内获取对象脑部的多个磁共振图像。 首先对两个或更多个磁共振图像进行比较，以确定脑中造影剂浓度的变化，并根据变化来评估血脑屏障功能。

公开(公告)号：US20170247429A1

公开(公告)日：2017-08-31

申请号：US15505526

申请日：2015-09-16

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Itzik Cooper ,  David Guez ,  David Last ,  Yoram Shechter ,  Matityahu Fridkin ,  Yael Mardor

IPC: C07K14/765 ,  A61K9/00 ,  A61K45/06

CPC classification number: C07K14/765 ,  A61K9/0085 ,  A61K38/385 ,  A61K45/06 ,  A61K47/643

Abstract: The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders.