公开(公告)号：US20240009315A1

公开(公告)日：2024-01-11

申请号：US18229224

申请日：2023-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Gideon SCHREIBER ,  Jiri ZAHRADNIK ,  Amnon BAR-SHIR ,  Yinon RUDICH ,  Andrea GALISOVA

IPC: A61K47/64 ,  A61K47/69

CPC classification number: A61K47/64 ,  A61K47/6911

Abstract: Particles having an ACE2 targeting moiety attached to an outer surface thereof are disclosed herein. The ACE2 targeting moiety comprises a polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD), wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501. Uses of the particles for treatment and diagnosis of diseases are also disclosed.

公开(公告)号：US20230263884A1

公开(公告)日：2023-08-24

申请号：US18122169

申请日：2023-03-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Gideon SCHREIBER ,  Jiri ZAHRADNIK ,  Yinon RUDICH

IPC: A61K39/215 ,  C07K14/005

CPC classification number: A61K39/215 ,  C07K14/005 ,  A61K38/00

Abstract: A polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD) is disclosed, wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501, wherein the polypeptide binds soluble, monomeric angiotensin-converting enzyme 2 (ACE2) receptor. Uses thereof are further disclosed.

公开(公告)号：US20210403854A1

公开(公告)日：2021-12-30

申请号：US17474208

申请日：2021-09-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ilan KOREN ,  Assaf VARDI ,  Yinon RUDICH ,  Adi VOLPERT ,  Joseph BOLLESS

IPC: C12M1/34 ,  C12Q1/02 ,  G01N21/31 ,  G01N21/64

Abstract: A method for monitoring species of algae for stress comprises growing a test set of algae of a given species, applying a stress of a predetermined kind to some of the algae, and irradiating the algae at a predetermined first set of wavelengths. The algae are then monitored at a predetermined second set of wavelengths to detect fluorescence and/or absorbance carried out on the first set of wavelengths by the stressed algae. The detected fluorescence and/or absorbance is compared for each irradiation wavelength between the stressed algae and unstressed algae to find signs indicating the applied stress. There is then a stage of searching through combinations of respective irradiation wavelengths and detected wavelengths to find a minimal set of irradiating and detected wavelengths that detects the stress. The smallest size set is then used in irradiating further sets of algae of the tested species to detect the given stress.