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公开(公告)号：US20190161476A1
公开(公告)日：2019-05-30
申请号：US16302310
申请日：2017-05-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , A61P35/00 , C07D403/04 , C07D403/12
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11001572B2
公开(公告)日：2021-05-11
申请号：US16800057
申请日：2020-02-25
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US20180194751A1
公开(公告)日：2018-07-12
申请号：US15741639
申请日：2016-08-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Xing Yan , Shuai Miao , Songsong Zhu
IPC分类号： C07D403/14 , C07D401/14 , A61P35/00 , C07D233/06 , C07D233/28 , C07D233/48 , C07D233/46
CPC分类号： C07D403/14 , A61K31/4184 , A61P35/00 , C07D233/06 , C07D233/28 , C07D233/46 , C07D233/48 , C07D401/14
摘要： An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
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公开(公告)号：US20200207745A1
公开(公告)日：2020-07-02
申请号：US16800057
申请日：2020-02-25
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US10654836B2
公开(公告)日：2020-05-19
申请号：US16302310
申请日：2017-05-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US10519148B2
公开(公告)日：2019-12-31
申请号：US15766692
申请日：2016-10-11
发明人： Dongliang Guan , Shouyi Sheng , Hua Bai
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
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公开(公告)号：US20240018130A1
公开(公告)日：2024-01-18
申请号：US18368362
申请日：2023-09-14
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11827625B2
公开(公告)日：2023-11-28
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： A61K31/506 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , A61K31/506 , A61P35/00 , C07D403/04 , C07D403/12 , C07D471/10 , C07D487/10 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11142531B2
公开(公告)日：2021-10-12
申请号：US16496861
申请日：2018-03-23
发明人： Hejun Lv , Dongliang Guan , Mingxiao Chen , Jinglu Wang , Lin Qian
IPC分类号： C07D495/04
摘要： The present invention relates to a cyano-substituted heteroarylpyrimidinone derivative represented by formula (I), a preparation method therefor and a use thereof as a therapeutic agent, in particular a use as an acetyl-CoA carboxylase (ACC) inhibitor, and the definition of each substituent in formula (I) is the same as the definition in the description.
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公开(公告)号：US20210221797A1
公开(公告)日：2021-07-22
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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