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公开(公告)号：US20190161476A1
公开(公告)日：2019-05-30
申请号：US16302310
申请日：2017-05-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , A61P35/00 , C07D403/04 , C07D403/12
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11001572B2
公开(公告)日：2021-05-11
申请号：US16800057
申请日：2020-02-25
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US20240018130A1
公开(公告)日：2024-01-18
申请号：US18368362
申请日：2023-09-14
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11827625B2
公开(公告)日：2023-11-28
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： A61K31/506 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , A61K31/506 , A61P35/00 , C07D403/04 , C07D403/12 , C07D471/10 , C07D487/10 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US20210221797A1
公开(公告)日：2021-07-22
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US20200207745A1
公开(公告)日：2020-07-02
申请号：US16800057
申请日：2020-02-25
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US10654836B2
公开(公告)日：2020-05-19
申请号：US16302310
申请日：2017-05-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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