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    Derivatives of glycinamide, their preparation and their use
    1.
    发明授权
    Derivatives of glycinamide, their preparation and their use 失效
    甘氨酰胺的衍生物，其制备及其用途

    公开(公告)号：US4639468A

    公开(公告)日：1987-01-27

    申请号：US768185

    申请日：1985-08-23

    申请人： Romeo Roncucci ,  Claude L. Gillet ,  Alexis H. Cordi ,  Mark A. Martens ,  Joseph L. Roba ,  Paul J. Niebes ,  Georges E. Lambelin ,  William R. Van Dorsser

    发明人： Romeo Roncucci ,  Claude L. Gillet ,  Alexis H. Cordi ,  Mark A. Martens ,  Joseph L. Roba ,  Paul J. Niebes ,  Georges E. Lambelin ,  William R. Van Dorsser

    IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/205 ,  C07C233/00 ,  C07C233/12 ,  C07C233/30 ,  C07C237/00 ,  C07C271/06 ,  C07C271/22

    CPC分类号： C07C255/00 ,  C07C271/22

    摘要： A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C.sub.5 -C.sub.18, a linear or ramified alkenyl group C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9, C.sub.10, C.sub.11, C.sub.12, C.sub.13, C.sub.14, C.sub.15, C.sub.16, C.sub.17 or C.sub.18, a linear or ramified alkynyl group C.sub.4 -C.sub.10, a linear or ramified acyl group C.sub.4 -C.sub.18, a linear or ramified alkyl group C.sub.1 -C.sub.10, substituted by a phenoxy group, by a hydroxy radical, by an acetoxy radical, by a carboxy radical, by a linear or ramified alkoxycarbonyl group C.sub.1 -C.sub.4, by a carbonyl radical, by a carboxaldehyde group, by an acetal or cetal group, by one or more phenyl groups, by one or more phenyl groups substituted by a halogen atom such as fluorine, chlorine or bromine,R.sub.1 represents hydrogen, a linear or ramified alkyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7, C.sub.8, C.sub.9 or C.sub.10, a linear or ramified acyl group C.sub.1 -C.sub.6, a benzoyl group, a linear or ramified alkoxycarbonyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7 or C.sub.8, a carboxamidomethyl group,R.sub.2 represents hydrogen, a linear or ramified alkyl C.sub.1, C.sub.2, C.sub.3, a phenyl group,R.sub.3 represents hydrogen, a linear or ramified alkyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7 or C.sub.8, a phenyl group, optionally substituted by a halogen atom, such as fluorine, chlorine or bromine,R.sub.4 represents hydrogen, a linear or ramified alkyl group C.sub.1, C.sub.2, C.sub.3, C.sub.4, C.sub.5, C.sub.6, C.sub.7 or C.sub.8 as well as salts of these derivatives with non toxic and pharmaceutically usable acids.

    摘要翻译： 通式I的甘氨酰胺衍生物：其中：R是直链或支链烷基C5-C18，直链或支链烯基C5，C6，C7，C8，C9，C10，C11，C12 C13，C14，C15，C16，C17或C18，直链或支链炔基C4-C10，线性或分枝酰基C4-C18，被苯氧基取代的直链或支链烷基C1-C10，由 羟基自由基，乙酰氧基，羧基，直链或分支的烷氧羰基C1-C4，羰基，羧醛基，缩醛或鲸蜡基，一个或多个苯基，被 一个或多个被卤素原子如氟，氯或溴取代的苯基，R 1表示氢，直链或支链烷基C1，C2，C3，C4，C5，C6，C7，C8，C9或C10，线性 或分支酰基C 1 -C 6，苯甲酰基，直链或支链烷氧基羰基C1，C2，C3，C4，C5，C6，C7或C8，羧酰胺基甲基，R2表示氢，线性或柱塞 烷基C1，C2，C3，苯基，R3表示氢，直链或支链烷基C1，C2，C3，C4，C5，C6，C7或C8，任选被卤素原子取代的苯基， 作为氟，氯或溴，R 4表示氢，直链或支链烷基C1，C2，C3，C4，C5，C6，C7或C8，以及这些衍生物与无毒和可药用酸的盐。