-
公开(公告)号：US20160193367A1
公开(公告)日：2016-07-07
申请号：US14916472
申请日：2014-09-05
发明人： Stéphane Hohn , Andrew Lennard Lewis , Sean Leo Willis , Matthew R. Dreher , Koorosh Ashrafi , Yiqing Tang
IPC分类号： A61K49/04 , A61L24/00 , C08F116/06 , A61L24/06
CPC分类号： A61K49/0442 , A61K49/04 , A61K49/0433 , A61K49/0438 , A61K49/0457 , A61K49/0476 , A61K49/048 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2400/06 , A61L2430/36 , C08F116/06
摘要： This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
摘要翻译： 本发明涉及可成像的聚合物，特别是包含聚乙烯醇的聚合物，以及制备它们的方法以及包含聚合物的栓塞微球。 该微球体在栓塞过程中可成像，并且可以装载药物或其它治疗剂以提供可成像的药物递送系统。
-
公开(公告)号：US20160030602A1
公开(公告)日：2016-02-04
申请号：US14777168
申请日：2014-03-14
申请人： Matthew R. DREHER , Bradford J. WOOD , Ayele H. NEGUSSIE , Andrew Leonard LEWIS , Yiqing TANG , Biocompatibles UK Limited
IPC分类号： A61K49/04 , C08L29/04 , C08F116/06
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译： 本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。 珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。 通过将预形成的水凝胶珠活化以进行亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备珠粒。 不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。
-
公开(公告)号：US11672876B2
公开(公告)日：2023-06-13
申请号：US16749370
申请日：2020-01-22
申请人： Biocompatibles UK Limited , THE UNITED STATES OF AMERICA, as represented by the Secretary Department of Health and Human Service
IPC分类号： A61K9/00 , A61K49/04 , C08F116/06 , C08L29/04 , B82Y5/00
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , C08F116/06 , C08L29/04 , B82Y5/00
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
-
公开(公告)号：US20180110884A1
公开(公告)日：2018-04-26
申请号：US15564786
申请日：2016-04-05
IPC分类号： A61K49/04
CPC分类号： A61K49/04 , A61B90/39 , A61B2090/101 , A61B2090/3908 , A61B2090/3954 , A61B2090/3966 , A61K49/0476 , A61N5/1049
摘要： Composition in the form of a shaped device, for use as a fiducial marker in tissues in the animal body, in radiotherapy and/or radiosurgery, characterized in that it comprises: —a core consisting of a colloidal dispersion of metal nanoparticles and/or oxides or metal salts having X-ray-contrast properties, where said nanoparticles are stabilized with surfactants, polymers or capping agents in a liquid vehicle, and —a polymeric casing that encapsulates the core, said device having a minimum size of not less than 500 microns and a maximum size not greater than 3000 microns.
-
公开(公告)号：US20150110722A1
公开(公告)日：2015-04-23
申请号：US14478213
申请日：2014-09-05
发明人： Stéphane HOHN , Andrew Lennard LEWIS , Sean Leo WILLIS , Matthew DREHER , Koorosh ASHRAFT , Yiqing TANG
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/04 , A61K49/0433 , A61K49/0438 , A61K49/0457 , A61K49/0476 , A61K49/048 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2400/06 , A61L2430/36 , C08F116/06
摘要： The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalised with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable during embolization therapy. The invention further relates to methods of making radiopaque polymers and radiopaque hydrogel microspheres to provide an imageable drug delivery system.
摘要翻译： 本发明涉及含有在栓塞治疗期间可成像的一种或多种共价结合的不透射线卤素的不透射线物质缩醛化的1,2-二醇或1,3-二醇基团的水凝胶。 本发明还涉及制造不透射线聚合物和不透射线水凝胶微球以提供可成像的药物递送系统的方法。
-
公开(公告)号：US08133959B2
公开(公告)日：2012-03-13
申请号：US13101499
申请日：2011-05-05
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
-
公开(公告)号：US4997454A
公开(公告)日：1991-03-05
申请号：US343761
申请日：1989-04-26
CPC分类号： A61K9/14 , A61K49/0476 , A61K9/1688 , Y10S514/951 , Y10S514/965
摘要： The invention involves a method for making uniformly sized particles from solid compounds. First, a suitable solid compound is dissolved in a suitable solvent. Then, a precipitating liquid is infused, precipitating non-aggregated particles with substantially uniform mean diameter. The particles are then separated from the solvent. Depending on the solid compound and the desired particle size, the parameters of temperature, ratio of non-solvent to solvent, infusion rate, stir rate, and volume can be varied according to the invention. The precipitating liquid may be aqueous or non-aqueous, depending upon the relative solubility of the compound and the desired suspending vehicle.
-
公开(公告)号：US07939611B2
公开(公告)日：2011-05-10
申请号：US11176638
申请日：2005-07-07
IPC分类号： C08F28/06 , C08F26/06 , C08F130/02 , C08F14/04
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
-
公开(公告)号：US20080102098A1
公开(公告)日：2008-05-01
申请号：US11589665
申请日：2006-10-30
申请人： Vipul Bhupendra Dave , Chao Chen
发明人： Vipul Bhupendra Dave , Chao Chen
CPC分类号： A61K49/04 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2250/0067 , A61F2250/0098 , A61K49/0404 , A61K49/0476
摘要： A medical device is constructed from a polymeric composition having properties such as increased visibility of the device and the ability to deliver therapeutic and other agents. The device is constructed with additives incorporated into the polymeric structure, such as a material that increases visibility of the device, while still maintaining desired mechanical characteristics such as high radial stiffness, minimized recoil values, and improved flexibility. The device can assume a wide range of geometries that are adaptable to various loading conditions In order to include performance-enhancing additives to the medical device without affecting mechanical performance, the additives are localized in discrete regions of a polymer structure from which a medical device will be formed. For example, a medical device can be prepared from a polymer form such as a tube containing radiopaque agent localized at its ends or in a desired pattern along the device.
摘要翻译： 医疗装置由具有诸如提高装置的可见性和递送治疗剂和其它药剂的能力等特性的聚合物组合物构成。 该装置由结合到聚合物结构中的添加剂构成，例如提高装置的可视性的材料，同时仍然保持期望的机械特性，例如高径向刚度，最小反冲值和改善的柔性。 该装置可以采用适用于各种加载条件的宽范围的几何形状。为了将性能增强添加剂包括在医疗装置中而不影响机械性能，添加剂定位在聚合物结构的离散区域中，医疗装置将从该区域 形成。 例如，医疗装置可以由聚合物形式制备，例如含有不透射线剂的管，其位于其末端或沿着该装置所需的图案。
-
公开(公告)号：US20060024266A1
公开(公告)日：2006-02-02
申请号：US11176638
申请日：2005-07-07
申请人： Donald Brandom , Joan Zeltinger , Eric Schmid , Joseph Mallon
发明人： Donald Brandom , Joan Zeltinger , Eric Schmid , Joseph Mallon
IPC分类号： A61K31/74
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.016 秒)
