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    Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
    5.
    发明授权
    Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 有权
    水凝胶根据环境变化及其制造和使用方法进行体积膨胀

    公开(公告)号：US08465779B2

    公开(公告)日：2013-06-18

    申请号：US13527485

    申请日：2012-06-19

    申请人： Gregory M. Cruise ,  Michael J. Constant

    发明人： Gregory M. Cruise ,  Michael J. Constant

    IPC分类号： A61K9/50

    CPC分类号： C08F22/385 ,  A61K9/0024 ,  A61K49/0457 ,  A61L31/145

    摘要： Generally, hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand in situ.

    摘要翻译： 通常，水凝胶通过形成液体反应混合物来制备，所述液体反应混合物含有至少部分的环境变化（例如，pH或温度的变化），b）的单体和/或聚合物 ）交联剂和c）聚合引发剂。 如果需要，可以将多孔性原子结合到液体反应混合物中以产生孔。 在形成水凝胶之后，除去孔结构以在水凝胶中产生孔。 这些水凝胶可以以许多形式制备，包括颗粒，细丝和颗粒。 这些水凝胶的生物医学用途包括其中将水凝胶植入患者体内的应用，并且在植入部位的环境条件导致水凝胶原位扩张。

    HYDROGELS THAT UNDERGO VOLUMETRIC EXPANSION IN RESPONSE TO CHANGES IN THEIR ENVIRONMENT AND THEIR METHODS OF MANUFACTURE AND USE
    6.
    发明申请
    HYDROGELS THAT UNDERGO VOLUMETRIC EXPANSION IN RESPONSE TO CHANGES IN THEIR ENVIRONMENT AND THEIR METHODS OF MANUFACTURE AND USE 有权
    水下体积膨胀对其环境变化的响应及其制造和使用方法

    公开(公告)号：US20120302654A1

    公开(公告)日：2012-11-29

    申请号：US13527485

    申请日：2012-06-19

    申请人： Gregory M. Cruise ,  Michael J. Constant

    发明人： Gregory M. Cruise ,  Michael J. Constant

    IPC分类号： C08L33/26

    CPC分类号： C08F22/385 ,  A61K9/0024 ,  A61K49/0457 ,  A61L31/145

    摘要： Generally, hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand in situ.

    摘要翻译： 通常，水凝胶通过形成液体反应混合物来制备，所述液体反应混合物含有至少部分的环境变化（例如，pH或温度的变化），b）的单体和/或聚合物 ）交联剂和c）聚合引发剂。 如果需要，可以将多孔性原子结合到液体反应混合物中以产生孔。 在形成水凝胶之后，除去孔结构以在水凝胶中产生孔。 这些水凝胶可以以许多形式制备，包括颗粒，细丝和颗粒。 这些水凝胶的生物医学用途包括其中将水凝胶植入患者体内的应用，并且在植入部位的环境条件导致水凝胶原位扩张。

    RADIOPAQUE INJECTABLE NUCLEUS HYDROGEL COMPOSITIONS
    7.
    发明申请
    RADIOPAQUE INJECTABLE NUCLEUS HYDROGEL COMPOSITIONS 审中-公开
    放射性注射核糖核酸组合物

    公开(公告)号：US20120276008A1

    公开(公告)日：2012-11-01

    申请号：US13094512

    申请日：2011-04-26

    申请人： Jared W. Walkenhorst ,  Keith A. Collins ,  Dennis Y. Lee ,  Thomas G. Wilson ,  Thomas J. Douville ,  Ulrich Berlemann

    发明人： Jared W. Walkenhorst ,  Keith A. Collins ,  Dennis Y. Lee ,  Thomas G. Wilson ,  Thomas J. Douville ,  Ulrich Berlemann

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0457

    摘要： In one embodiment, the invention relates to a composition suitable for preparing a hydrogel useful as replacement material for all or part of a disc nucleus. The composition comprises: a curable, cross-linkable, non-immunogenic, non-toxic protein comprising a minimum of about 10% and a maximum of about 25% of the hydrogel by weight; a metal contrast agent comprising a minimum of about 2% and a maximum of about 70% of the hydrogel by weight; and a crosslinker comprising a minimum of about 0.1% and a maximum of about 10% of the hydrogel by weight; wherein the composition has a discernable radiopacity level.

    摘要翻译： 在一个实施方案中，本发明涉及适用于制备可用作全部或部分椎间盘核的替代材料的水凝胶的组合物。 该组合物包含：可固化的，可交联的，非免疫原性的无毒性蛋白，其包含至少约10重量％和最多约25重量％的水凝胶; 金属造影剂，其包含按重量计最少约2％和最多约70％的水凝胶; 和包含至少约0.1重量％和最多约10重量％的水凝胶的交联剂; 其中所述组合物具有可辨别的不透射线水平。

    CT NEGATIVE CONTRAST MEDIUM OF AQUEOUS MATRIX FOR DIGESTIVE TRACT AND THE PREPARATION METHOD THEREOF
    8.
    发明申请
    CT NEGATIVE CONTRAST MEDIUM OF AQUEOUS MATRIX FOR DIGESTIVE TRACT AND THE PREPARATION METHOD THEREOF 失效
    用于消除冲击的水性基质的负压对比度介质及其制备方法

    公开(公告)号：US20100166668A1

    公开(公告)日：2010-07-01

    申请号：US12300240

    申请日：2006-05-22

    申请人： Xiaohui Wei ,  Jianrong Xu ,  Yuhong Xu

    发明人： Xiaohui Wei ,  Jianrong Xu ,  Yuhong Xu

    IPC分类号： A61K49/04 ,  A61P1/00

    CPC分类号： A61K49/0409 ,  A61K49/0457

    摘要： An aqueous negative contrast agent for CT imaging of the gastrointestinal tract and the preparation method thereof. The agent is used in biological and pharmaceutical field. Its components and the weight percent are: hydrogel matrix 0.01-1%, micro-/nano-particles of the materials with low densities 5-50%, stabilization agents 0.1-5%, the rest is deionized water. The preparation method is: stabilization agents are added into the hydrogel matrix made of natural or synthetic hydrophilic polymers, then micro-/nano-particles of the materials with low CT densities are added or prepared, and uniformly dispersed in the hydrogel matrix. The CT density of the resulted aqueous negative contrast agent for CT imaging of the gastrointestinal tract is −30HU to −500HU. It can decrease the CT density inside the intestine lumen to lower than −30HU. The intestine wall can be depicted clearly and the CT signals intensities inside lumen are uniform. It is feasible for 3D images processing such as virtual endoscopy reconstruction with the negative contrast agent. The agent is safe, stable and nontoxic. It will not lead to diarrhea after administration. It is of great significance for the improved sensitivity and specificity of CT diagnosis for the diseases on the intestinal wall and lumen.

    摘要翻译： 用于胃肠道CT成像的水性阴性造影剂及其制备方法。 该药剂用于生物制药领域。 其组分和重量百分比为：水凝胶基质0.01-1％，低密度材料的微/纳米颗粒为5-50％，稳定剂为0.1-5％，其余为去离子水。 制备方法是：将稳定剂加入由天然或合成亲水性聚合物制成的水凝胶基质中，然后加入或制备具有低CT密度的材料的微/纳米颗粒，并均匀分散在水凝胶基质中。 所得到的用于胃肠道CT成像的水性阴性造影剂的CT密度为-30HU至-500HU。 可以将肠腔内的CT密度降低到-30HU以下。 可以清楚地描绘肠壁，并且内部的CT信号强度是均匀的。 用负性造影剂进行虚拟内窥镜重建等3D图像处理是可行的。 该药剂安全，稳定无毒。 行政后不会导致腹泻。 对肠壁和内腔疾病CT诊断的敏感性和特异性提高具有重要意义。

    RADIOGRAPHIC CONTRAST AGENT FOR POSTMORTEM, EXPERIMENTAL AND DIAGNOSTIC ANGIOGRAPHY
    9.
    发明申请
    RADIOGRAPHIC CONTRAST AGENT FOR POSTMORTEM, EXPERIMENTAL AND DIAGNOSTIC ANGIOGRAPHY 有权
    放射学对比剂，实验和诊断方法

    公开(公告)号：US20100021389A1

    公开(公告)日：2010-01-28

    申请号：US12441822

    申请日：2007-09-12

    申请人： Silke Grabherr ,  Erich Gygax

    发明人： Silke Grabherr ,  Erich Gygax

    IPC分类号： A61K49/04 ,  A61K49/00 ,  A61P43/00

    CPC分类号： A61K49/0457 ,  A61K49/0409 ,  A61K49/0438

    摘要： A contrast agent for angiography is disclosed, in particular, for examining animal or human bodies or components thereof such as members or organs thereof, comprising an essentially oil-based apolar contrast component for X-ray examinations, the contrast component having a contrast component viscosity in the range of 30-100 mPas. The contrast agent is characterised in that the contrast component is present in a mixture with at least one further apolar component, the viscosity of which is less than or at most equal to the contrast component viscosity. Methods for angiography examination are also disclosed, in which such a contrast agent or also a polar contrast agent are used at least periodically and applications of such contrast agents.

    摘要翻译： 公开了用于血管造影的造影剂，特别是用于检查动物或人体或其组分，例如其成员或器官，其包含用于X射线检查的基本油性非极性对比成分，所述造影剂组分具有造影剂组分粘度 在30-100 mPas的范围内。 造影剂的特征在于，对比成分与具有至少一种另外的非极性组分的混合物存在，其粘度小于或至多等于对比组分粘度。 还公开了用于血管造影检查的方法，其中至少周期性地使用这种造影剂或极性造影剂并应用这种造影剂。

    Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
    10.
    发明授权
    Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 有权
    水凝胶根据环境变化及其制造和使用方法进行体积膨胀

    公开(公告)号：US06878384B2

    公开(公告)日：2005-04-12

    申请号：US09804935

    申请日：2001-03-13

    申请人： Gregory M. Cruise ,  Michael J. Constant

    发明人： Gregory M. Cruise ,  Michael J. Constant

    IPC分类号： A61L31/00 ,  A61K9/00 ,  A61K49/04 ,  A61L26/00 ,  A61L27/00 ,  A61F2/02 ,  A61K9/14 ,  A61K47/30

    CPC分类号： C08F22/385 ,  A61K9/0024 ,  A61K49/0457 ,  A61L31/145

    摘要： Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand in situ.

    摘要翻译： 响应于其环境变化（例如pH或温度的变化）及其制造和使用方法，体积膨胀的水凝胶。 通常，水凝胶通过形成液体反应混合物来制备，所述液体反应混合物含有至少部分其至少部分对环境变化（例如pH或温度变化）的单体和/或聚合物， b）交联剂，和c）聚合引发剂。 如果需要，可以将多孔性原子结合到液体反应混合物中以产生孔。 在形成水凝胶之后，除去孔结构以在水凝胶中产生孔。 水凝胶也可以被处理以使其呈现未膨胀的体积，其中它保持直到其环境变化导致它膨胀。 这些水凝胶可以以许多形式制备，包括颗粒，细丝和颗粒。 这些水凝胶的生物医学用途包括其中将水凝胶植入患者体内的应用，并且在植入部位的环境条件导致水凝胶原位扩张。