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    Stabilization of vinylether and vinyl lactam formulations against hydrolysis
    1.
    发明授权
    Stabilization of vinylether and vinyl lactam formulations against hydrolysis 有权
    乙烯基醚和乙烯基内酰胺配方的抗水解作用

    公开(公告)号：US06417356B1

    公开(公告)日：2002-07-09

    申请号：US09764641

    申请日：2001-01-18

    Applicant: Arvind M. Mathur ,  James A. Dougherty

    Inventor： Arvind M. Mathur ,  James A. Dougherty

    IPC: C07B6300

    CPC classification number: C07C41/46 ,  C07D201/18 ,  C07C43/16

    Abstract: This invention relates to a composition containing (a) a component selected from the group of a mono- or poly- vinyl substituted mono- or poly-ether, a mono- or poly- vinyl substituted lactam, or a mixture thereof contained in an acidic medium and (b) an aliphatic, primary or secondary mono- or poly-amine at a concentration sufficient to adjust the pH of the composition above

    Abstract translation: 本发明涉及一种组合物，其含有（a）选自单 - 或多 - 乙烯基取代的单醚或聚醚，单或多乙烯基取代的内酰胺或其包含在酸性中的混合物的组分 介质和（b）以足以调节上述组合物的pH的浓度的脂族，伯或仲或单 - 胺

    RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof
    3.
    发明申请
    RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof 审中-公开
    RS）-2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺化合物，其具有相似的作用的调节活性，药物（变体）及其用途，组合物（变体）

    公开(公告)号：US20140315972A1

    公开(公告)日：2014-10-23

    申请号：US14346445

    申请日：2012-09-20

    Applicant: Valentina Ivanovna Akhapkina ,  Roman Vitalyevich Akhapkin

    Inventor： Valentina Ivanovna Akhapkina ,  Roman Vitalyevich Akhapkin

    IPC: C07D207/27 ,  G01N31/16

    CPC classification number: G01N31/16 ,  A61K31/4015 ,  C07D201/16 ,  C07D201/18 ,  C07D207/27 ,  Y10T436/145555

    Abstract: The invention relates to a compound (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide having modulatory activity with a commensurate effect, to a pharmaceutical substance (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide containing: 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide—no less than 99.0% and no more than 100.5% on dry basis, individual related impurities individually or in total—no more than 0.2%; residual amounts of organic solvents individually or in total—no more than 3000 ppm. The invention also relates to a method for producing the pharmaceutical substance differing in that the obtained raw materials are subjected to purification, crystallization and stabilization of the compound by processing it with demineralized (distilled) water, and the isothermal crystallization from propanol followed by drying. The invention also relates to compositions for internal and external application. The invention provides higher efficacy, safety, stability and width of therapeutic application. 55 cl, 3 dwg, 80 tbl, 27 ex.

    Abstract translation: 本发明涉及具有相似作用的调节活性的化合物（RS）-2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺与药用物质（RS）-2-（2-氧代-4 - 2-（2-氧代-4-苯基吡咯烷-1-基）乙酰胺 - 不少于99.0％且不大于100.5％，单独或全部单独的相关杂质， 不超过0.2％; 剩余量的有机溶剂单独或总计不超过3000ppm。 本发明还涉及一种生产药物的方法，其不同之处在于，所得到的原料通过用软化（蒸馏）的水进行处理而进行化合物的纯化，结晶和稳定化，并用丙醇等温结晶，然后干燥。 本发明还涉及用于内部和外部应用的组合物。 本发明提供更高的疗效，安全性，稳定性和宽度的治疗应用。 55 cl，3 dwg，80 tbl，27 ex。

    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY
    6.
    发明申请
    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY 审中-公开
    制备具有改善颜色质量的N-ALKYL LACTAM的方法

    公开(公告)号：US20100286411A1

    公开(公告)日：2010-11-11

    申请号：US12842228

    申请日：2010-07-23

    Applicant: Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    Inventor： Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    IPC: C07D207/12

    CPC classification number: C07D201/18 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10

    Abstract: A process for preparing an N-alkyllactam with improved color quality, wherein from 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases from 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyllactam.A mixture comprising at least 99.0% by weight of an N-alkyllactam and in the range from 100 to 5000 ppm by weight of a C1-10-alcohol or of an acetal, aminal or of an Orthoester which releases in the range from 100 to 5000 ppm by weight of a C1-10-alcohol.

    Abstract translation: 一种制备具有改进的颜色质量的N-烷基内酰胺的方法，其中将0.01至10重量％的C 1-10醇或从0.01至10重量％的C 1-10醇释放的化合物加入到 N-烷基内酰胺。 一种混合物，其包含至少99.0重量％的N-烷基内酰胺，并且在100至5000重量ppm的C 1-10醇或缩醛，缩醛或直角酯中，其释放范围为100至 5000重量ppm的C 1-10醇。

    Polylactam composition containing hexaorgano distannane
    8.
    发明授权
    Polylactam composition containing hexaorgano distannane 失效
    含有六有机二锡烷的聚内酰胺组合物

    公开(公告)号：US4108828A

    公开(公告)日：1978-08-22

    申请号：US586960

    申请日：1975-06-16

    Applicant: Jean W. Bouchoux ,  William A. Larkin

    Inventor： Jean W. Bouchoux ,  William A. Larkin

    IPC: C07D201/18 ,  C08G69/18 ,  C08K5/57 ,  C08G69/14

    CPC classification number: C08K5/57 ,  C07D201/18 ,  C08G69/18

    Abstract: Hexaorgano distannanes of the general formula R.sub.3 Sn--SnR.sub.3 significantly reduce or eliminate the discoloration which occurs when mixtures containing an alkali metal salt of a lactam are stored under an inert atmosphere for extended periods of time at temperatures between ambient and 100.degree. C. R in the foregoing formula represents a monovalent hydrocarbon radical containing between 1 and 20 carbon atoms.

    Abstract translation: 通式为R 3 Sn-SnR 3的六碳偶氮二苯胺显着降低或消除了当含有内酰胺的碱金属盐的混合物在惰性气氛下在环境温度和100℃之间的温度下长时间储存​​时发生的变色。 上述式表示含有1至20个碳原子的单价烃基。

    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY
    9.
    发明申请
    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY 审中-公开
    制备具有改善颜色质量的N-ALKYL LACTAM的方法

    公开(公告)号：US20100286399A1

    公开(公告)日：2010-11-11

    申请号：US12842263

    申请日：2010-07-23

    Applicant: Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    Inventor： Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    IPC: C07D211/76 ,  C07D207/267

    CPC classification number: C07D201/18 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10

    Abstract: A process for preparing an N-alkyllactam with improved color quality, wherein from 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases from 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyllactam.A mixture comprising at least 99.0% by weight of an N-alkyllactam and in the range from 100 to 5000 ppm by weight of a C1-10-alcohol or of an acetal, aminal or of an orthoester which releases in the range from 100 to 5000 ppm by weight of a C1-10-alcohol.

    Abstract translation: 一种制备具有改进的颜色质量的N-烷基内酰胺的方法，其中将0.01至10重量％的C 1-10醇或从0.01至10重量％的C 1-10醇释放的化合物加入到 N-烷基内酰胺。 一种混合物，其包含至少99.0重量％的N-烷基内酰胺和100-5000重量ppm的C1-10醇或缩醛，缩醛或原酸酯，其释放范围为100至 5000重量ppm的C 1-10醇。

    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY
    10.
    发明申请
    PROCESS FOR THE PREPARATION OF AN N-ALKYL LACTAM WITH IMPROVED COLOUR QUALITY 审中-公开
    制备具有改善颜色质量的N-ALKYL LACTAM的方法

    公开(公告)号：US20090182139A1

    公开(公告)日：2009-07-16

    申请号：US12296115

    申请日：2007-03-29

    Applicant: Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    Inventor： Tobias Wabnitz ,  Rolf Pinkos ,  Karl Ott

    IPC: C07D201/08 ,  C07D207/267 ,  C07D201/02 ,  C07D211/06

    CPC classification number: C07D201/18 ,  C07D207/267 ,  C07D211/76 ,  C07D223/10

    Abstract: A process for preparing an N-alkyllactam with improved color quality, wherein from 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases from 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyllactam.A mixture comprising at least 99.0% by weight of an N-alkyllactam and in the range from 100 to 5000 ppm by weight of a C1-10-alcohol or of an acetal, aminal or of an orthoester which releases in the range from 100 to 5000 ppm by weight of a C1-10-alcohol.

    Abstract translation: 一种制备具有改进的颜色质量的N-烷基内酰胺的方法，其中将0.01至10重量％的C 1-10醇或从0.01至10重量％的C 1-10醇释放的化合物加入到 N-烷基内酰胺。 一种混合物，其包含至少99.0重量％的N-烷基内酰胺和100-5000重量ppm的C1-10醇或缩醛，缩醛或原酸酯，其释放范围为100至 5000重量ppm的C 1-10醇。

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