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    Avermectin and praziquantel combination therapy
    3.
    发明申请
    Avermectin and praziquantel combination therapy 审中-公开
    阿维菌素和吡喹酮联合治疗

    公开(公告)号：US20030064941A1

    公开(公告)日：2003-04-03

    申请号：US10116880

    申请日：2002-04-05

    申请人： Pfizer Inc.

    发明人： Bernard Frank Bishop

    IPC分类号： A01N043/04 ,  A01N043/58 ,  A01N043/60

    CPC分类号： A01N43/90 ,  A61K9/08 ,  A61K31/495 ,  A61K31/7048 ,  A61K47/10 ,  A01N2300/00 ,  A61K2300/00

    摘要： An antiparasitic combination therapy compising a combination of a 13-monosaccharide 5-oxime avermectin, such as selamectin, and praziquantel in a veterinarily acceptable carrier, diluent or adjuvant. Also provided is a method of treatment or prophylaxis of a parasitic infestation as well as a kit useful in the treatment or prophylaxis of a parasitic infestation of flea, heartworm or tapeworm in a mammal.

    摘要翻译： 在兽医学上可接受的载体，稀释剂或佐剂中，组合使用13-单糖5-肟类除虫菌素（如selamectin）和吡喹酮的抗寄生虫疗法联合疗法。 还提供了治疗或预防寄生虫侵袭的方法以及可用于治疗或预防哺乳动物中跳蚤，心虫或绦虫的寄生虫侵袭的试剂盒。

    Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
    4.
    发明申请
    Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use 失效
    亚硝基化和亚硝基化环加氧酶-2抑制剂，组合物和使用方法

    公开(公告)号：US20010041726A1

    公开(公告)日：2001-11-15

    申请号：US09741816

    申请日：2000-12-22

    发明人： Ramani R. Bandarage ,  Upul K. Bandarage ,  Xinqin Fang ,  David S. Garvey ,  L. Gordon Letts ,  Joseph D. Schroeder ,  Sang William Tam

    IPC分类号： A61K031/495 ,  A61K031/50 ,  A01N043/58 ,  A01N043/60 ,  A61K031/41 ,  A01N043/82

    CPC分类号： C07D207/333 ,  C07C317/46 ,  C07C381/00 ,  C07D209/12 ,  C07D209/18 ,  C07D231/12 ,  C07D231/14 ,  C07D233/64 ,  C07D237/14 ,  C07D261/08 ,  C07D263/20 ,  C07D307/58 ,  C07D311/12 ,  C07D413/12 ,  C07D471/04

    摘要： The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent, such as, steroids, nonsteroidal antiinflammatory compounds (NSAID), 5-lipoxygenase (5-LO) inhibitors, leukotriene B4 (LTB4) receptor antagonists, leukotriene A4 (LTA4) hydrolase inhibitors, 5-HT agonists, 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) inhibitors, H antagonists, antineoplastic agents, antiplatelet agents, decongestants, diuretics, sedating or non-sedating anti-histamines, inducible nitric oxide synthase inhibitors, opioids, analgesics, Helicobacter pylori inhibitors, proton pump inhibitors, isoprostane inhibitors, and mixtures thereof. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

    摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂和包含至少一种亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂的新组合物，和任选的至少一种可以提供， 转移或释放一氧化氮，刺激一氧化氮的内源性合成，提高内源性内皮水平的内皮衍生的松弛因子，或是一氧化氮合酶的底物，和/或任选的至少一种治疗剂，例如类固醇，非甾体抗炎化合物 （NSAID），5-脂氧合酶（5-LO）抑制剂，白细胞三烯B4（LTB4）受体拮抗剂，白细胞三烯A4（LTA4）水解酶抑制剂，5-HT激动剂，3-羟基-3-甲基戊二酰辅酶A（HMGCoA）抑制剂，H 拮抗剂，抗肿瘤剂，抗血小板剂，减充血剂，利尿剂，镇静剂或非镇静性抗组胺药，诱导型一氧化氮合酶抑制剂，阿片样物质，镇痛药，幽门螺杆菌抑制剂 质子泵抑制剂，异前列烷烷抑制剂及其混合物。 本发明还提供了包含至少一种母体COX-2抑制剂和至少一种一氧化氮供体以及任选的至少一种治疗剂的新型组合物。 本发明还提供用于治疗炎症，疼痛和发烧的试剂盒和方法; 用于治疗和/或改善COX-2抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾毒性; 并且用于治疗和/或预防由环氧合酶-2水平升高引起的其它疾病。

    Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
    5.
    发明申请
    Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof 失效
    芳香族二酰胺衍生物，农业或园艺用途的化学品及其用途

    公开(公告)号：US20040009982A1

    公开(公告)日：2004-01-15

    申请号：US10168334

    申请日：2002-09-20

    发明人： Masanori Tohnishi ,  Eiji Kohno ,  Hayami Nakao ,  Tateki Nishida ,  Takashi Furuya ,  Toshiaki Shimizu ,  Akira Seo ,  Kazuyuki Sakata ,  Shinsuke Fujioka

    IPC分类号： C07D43/02 ,  C07D41/02 ,  A01N043/58 ,  A01N043/54 ,  A01N037/18

    CPC分类号： C07D295/205 ,  A01N37/30 ,  A01N41/06 ,  A01N43/16 ,  A01N43/28 ,  A01N43/40 ,  A01N47/12 ,  A01N47/28 ,  A01N57/14 ,  C07C233/66 ,  C07C233/69 ,  C07C233/75 ,  C07C233/78 ,  C07C239/16 ,  C07C271/12 ,  C07C271/20 ,  C07C271/28 ,  C07C275/14 ,  C07C307/06 ,  C07C311/05 ,  C07C311/18 ,  C07C323/12 ,  C07C323/43 ,  C07C335/08 ,  C07C2601/02 ,  C07F9/2458

    摘要： The present invention relates to an aromatic diamide derivative represented by the general formula (I): 1 nullA1 is optionally substituted (C1-C8)alkylene group, (C3-C8)alkenylene group or the like, B is nullOnull or nullN(R4)null (wherein R4 is H, (C1-C6)alkyl, halo(C1-C6)alkyl or the like), R1 is H, (C1-C6)alkyl, optionally substituted phenyl, optionally substituted heterocyclic group, or the like, R2 and R3 are each H, (C3-C6)cycloalkyl or -A2-R8 (A2 is nullC(nullO)null, nullC(nullS)null or nullC (nullNR9)null, R8 and R9 are each H, (C1-C6)alkyl or the like), Q1 to Q5 are each carbon or nitrogen, X and Y are each halogen, cyano, nitro, (C3-C6)cycloalkyl, optionally substituted phenyl, optionally substituted heterocyclic group, or the like, n is 0 to 4, m is 1 to 5, and Z1 and Z2 are each O or Snull or a salt thereof, an agricultural and horticultural chemical, and a usage of the chemical. The agricultural and horticultural chemicals of the present invention exhibit remarkable controlling effects against various insect pests such as agricultural, forest and horticultural insect pests, and stored grain insect pests, etc., which injure paddy rice, fruit trees, vegetables, other crop plants, flowers and ornamental plants, and the like.

    摘要翻译： 本发明涉及由通式（I）表示的芳族二酰胺衍生物：[A 1]为任选取代的（C 1 -C 8）亚烷基，（C 3 -C 8）亚烯基等，B为-O- 或-N（R 4） - （其中R 4是H，（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基等），R 1是H，（C 1 -C 6） 烷基，任选取代的苯基，任选取代的杂环基等，R 2和R 3各自为H，（C 3 -C 6）环烷基或-A 2 -R 8（A 2） 是-C（= O） - ， - C（= S） - 或-C（= NR 9） - ，R 8和R 9各自为H，（C 1 -C 6）烷基等 ），Q 1至Q 5各自为碳或氮，X和Y各自为卤素，氰基，硝基，（C 3 -C 6）环烷基，任选取代的苯基，任选取代的杂环基等，n为 0〜4，m为1〜5，Z 1和Z 2各自为O或S]或其盐，农业和园艺化学品，以及该化学品的用途。 本发明的农，园艺化学品对农，林，园艺害虫等各种害虫和储存的谷类害虫等对水稻，果树，蔬菜，其他作物， 花和观赏植物等。

    2-Phenyl-2h-pyridazine-3-ones
    7.
    发明申请
    2-Phenyl-2h-pyridazine-3-ones 审中-公开
    2-苯基-2h - 哒嗪-3-酮

    公开(公告)号：US20030162662A1

    公开(公告)日：2003-08-28

    申请号：US10257329

    申请日：2002-10-10

    发明人： Michael Puhl ,  Thorsten Volk ,  Gerhard Hamprecht ,  Robert Reinhard ,  Ingo Sagasser ,  Cyrill Zagar ,  Matthias Witschel ,  Helmut Walter

    IPC分类号： A01N043/58 ,  C07D237/02

    CPC分类号： A01N43/58 ,  C07D237/14

    摘要： The invention relates to 2-phenyl-2H-pyridazin-3-ones of the general formula I 1 in which the variables R1, R2, X, Y and Z have the following meanings: X is halogen; Y is fluorine or chlorine; Z is oxygen; R1 is hydrogen or C1-C4-alkyl; R2 is chlorine, OR3 or NR4R5, in which R3, R4 and R5 have the meanings indicated in claim 1, Z can also be a group NR6 if R2 is a group OR7, in which R6 and R7 have the meanings indicated in claim 1, and to the agriculturally utilizable salts of compounds of the formula I. The invention furthermore relates to the use of compounds I and their salts as herbicides and/or for the desiccation and/or defoliation of plants, herbicidal compositions and compositions for the desiccation and/or defoliation of plants, which contain the compounds I and/or their salts as active substances, and processes for controlling undesired vegetation (weeds) and for the desiccation and/or defoliation of plants using the compounds I and/or their salts.

    摘要翻译： 本发明涉及通式Ⅰ的2-苯基-2H-哒嗪-3-酮，其中R 1，R 2，X，Y和Z的定义如下：X是卤素; Y是氟或氯; Z是氧; R1是氢或C1-C4-烷基; R2是氯，OR3或NR4R5，其中R3，R4和R5具有权利要求1所示的含义，如果R 2是OR 7，则Z也可以是NR 6基团，其中R 6和R 7具有权利要求1所示的含义， 本发明还涉及化合物I及其盐作为除草剂和/或用于干燥和/或脱叶的植物，除草组合物和用于干燥和/或干燥的组合物的用途， 或含有化合物I和/或其盐作为活性物质的植物的脱叶，以及使用化合物I和/或其盐对植物进行干燥和/或脱叶的防治不希望的植被（杂草）的方法。

    2-Phenyl-2h-pyridazine-3-ones
    8.
    发明申请
    2-Phenyl-2h-pyridazine-3-ones 审中-公开
    2-苯基-2h - 哒嗪-3-酮

    公开(公告)号：US20030130123A1

    公开(公告)日：2003-07-10

    申请号：US10257311

    申请日：2002-10-10

    发明人： Michael Puhl ,  Thorsten Volk ,  Gerhard Hamprecht ,  Robert Reinhard ,  Ingo Sagasser ,  Cyrill Zagar ,  Karl-Otto Westphalen ,  Matthias Witschel ,  Helmut Walter

    IPC分类号： A01N043/58 ,  C07D237/14

    CPC分类号： C07C243/22 ,  A01N43/58 ,  C07C251/76 ,  C07D237/14

    摘要： The invention relates to 2-phenyl-2H-pyridazin-3-ones of the general formula I 1 in which the variables R1, R2 and X have the following meanings: X is halogen; R1 is hydrogen or C1-C4-alkyl; R2 is chlorine, OR3 or NR4R5, in which R3, R4 and R5 have the meanings indicated in claim 1, and to the agriculturally utilizable salts of compounds of the formula I. The invention furthermore relates to the use of compounds I and their salts as herbicides and/or for the desiccation and/or defoliation of plants, herbicidal compositions and compositions for the desiccation and/or defoliation of plants, which contain the compounds I and/or their salts as active substances, and processes for controlling undesired vegetation (weeds) and for the desiccation and/or defoliation of plants using the compounds I and/or their salts.

    摘要翻译： 本发明涉及通式Ⅰ的2-苯基-2H-哒嗪-3-酮，其中变量R1，R2和X具有下列含义：X为卤素; R1是氢或C1-C4-烷基; R2是氯，OR3或NR4R5，其中R3，R4和R5具有权利要求1所示的含义，以及式I化合物的农业上可用的盐。本发明还涉及化合物I及其盐的用途 除草剂和/或用于干燥和/或脱叶的植物，除草组合物和用于干燥和/或脱叶的植物的组合物，其含有化合物I和/或其盐作为活性物质，以及控制不希望的植物（杂草）的方法 ）和使用化合物I和/或其盐的植物的干燥和/或脱叶。

    Pyridazinone derivatives
    9.
    发明申请
    Pyridazinone derivatives 失效
    哒嗪酮衍生物

    公开(公告)号：US20020026048A1

    公开(公告)日：2002-02-28

    申请号：US09732901

    申请日：2000-12-11

    申请人： Sumitomo Chemical Co. Ltd.

    发明人： Takashi Komori

    IPC分类号： A01N043/58 ,  C07D237/04 ,  C07D237/30

    CPC分类号： C07D237/14 ,  A01N43/58 ,  C07D237/26 ,  C07D237/30

    摘要： This invention provides pyridazinone derivatives encompassed by the following the formula: 1 wherein, R1, R2, R3, R4, R5 and R7 represent a hydrogen atom and the like, and R6 represents a C1-C3 alkyl and the like. The pyridazinone derivatives have excellent herbicidal activity, therefore, they can be used as an active ingredient for herbicidal compositions and can be utilized in herbicidal method, which are also described.

    摘要翻译： 本发明提供下列通式所示的哒嗪酮衍生物：其中R1，R2，R3，R4，R5和R7代表氢原子等，R6表示C1-C3烷基等。 哒嗪酮衍生物具有优异的除草活性，因此它们可以用作除草组合物的活性成分，并且可以用于还描述的除草方法中。

    Process for the control of weeds
    10.
    发明申请
    Process for the control of weeds 有权
    防治杂草的过程

    公开(公告)号：US20040097373A1

    公开(公告)日：2004-05-20

    申请号：US10609084

    申请日：2003-06-27

    发明人： Bruce Lee ,  Andreas Zoschke ,  Hans Peter Lutz

    IPC分类号： A01N057/00 ,  A01N043/60 ,  A01N043/58

    CPC分类号： A01N57/20 ,  A01N2300/00

    摘要： Undesired plant growth in cultivations of useful plants which are resistant to phopho-herbicides, may be controlled with herbicidal compositions, which contain, in addition to the usual inert formulation assistants, a phospho-herbicide and a synergistic amount of at least one further herbicide selected from the group comprising prosulfuron, primisulfuron, dicamba, pyridate, dimethenamide and its S-enantiomer, metolachlor and its S-enantiomer, fluometuron, propaquizafop, atrazine, clodinafop, norflurazone, ametryn, terbutylazine, simazine, prometryn, NOA-402989, as well as the compounds of formulae 1

    摘要翻译： 可以用除草组合物控制对磷光除草剂具有抗性的有用植物的培养中不期望的植物生长，除草剂除通常的惰性制剂助剂之外还含有磷酸除草剂和协同量的至少一种另外的除草剂 来自包含次磺隆，原嘧磺隆，麦草畏，吡哆酸，二甲酰胺及其S-对映异构体，异丙甲草胺及其S-对映异构体，fluometuron，propaquizafop，莠去津，clodinafop，norflurazone，ametryn，terbutylazine，simazine，prometryn，NOA-402989的组 作为式的化合物