公开(公告)号：US20180273661A1

公开(公告)日：2018-09-27

申请号：US15762157

申请日：2016-09-22

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Martin Alexander Zuideveld ,  Jaiprakash Brijlal Sainani ,  Osamah Al-Humaidan ,  Sudhakar R. Padmanabhan ,  Prashant Sukumar Shinge ,  Sharankumar G. Shetty ,  Abbas-Alli Ghudubhai Shaikh

IPC: C08F110/06 ,  C07C231/14 ,  C07C233/75

CPC classification number: C08F110/06 ,  C07C231/14 ,  C07C233/75 ,  C07C233/88 ,  C08F4/6565 ,  C08F2500/15 ,  C08F2500/18 ,  C08F4/651

Abstract: The present invention relates to a compound according to Formula (I) wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom, an aryl group or an alkyl group; and wherein R3, R4, R5 and R6, are the same or different and are each independently a hydrogen atom, a halogen atom, a cyano group, an amino group, a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, and alkylaryl groups or an alkoxy group, and one or more combinations thereof as internal electron donor and to a process for the synthesis of a compound according to Formula (I), wherein R1 is a hydrocarbyl group selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, alkoxycarbonyl and alkylaryl groups, and one or more combinations thereof; wherein R2 is a hydrogen atom or an alkyl group; wherein R3, R4, R5 and R6, are the same or different and are each independently selected from a group consisting of a hydrogen atom; a hydrocarbyl, preferably, said process comprising the step of reacting a compound according to Formula (II) [R1—C(═O)Cl] with a compound according to Formula (III) to obtain the compound according to Formula (I) and to the use of these compounds as internal donor in Ziegler-Natta catalysis of olefins.

公开(公告)号：US20180230084A1

公开(公告)日：2018-08-16

申请号：US15892302

申请日：2018-02-08

Applicant: Southern Research Institute

Inventor： Ashish Kumar Pathak ,  Syed Kaleem Ahmed ,  Corinne E. Augelli-Szafran ,  Joseph A. Maddry

IPC: C07C233/75 ,  C07D231/14 ,  C07D233/90 ,  C07D277/56 ,  C07D261/18 ,  C07D307/68 ,  C07D333/38 ,  C07D241/24 ,  C07D271/12 ,  C07D239/28 ,  C07C255/41 ,  C07D213/56 ,  C07D213/81 ,  C07D307/85 ,  C07D309/08 ,  C07D213/30 ,  C07D209/46 ,  C07D223/16 ,  A61P31/12

CPC classification number: C07C233/75 ,  A61P31/12 ,  C07C233/29 ,  C07C233/60 ,  C07C233/65 ,  C07C235/48 ,  C07C255/33 ,  C07C255/41 ,  C07C255/58 ,  C07C311/21 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2602/12 ,  C07C2603/74 ,  C07D209/46 ,  C07D213/30 ,  C07D213/56 ,  C07D213/81 ,  C07D223/16 ,  C07D231/14 ,  C07D233/90 ,  C07D239/28 ,  C07D241/24 ,  C07D261/18 ,  C07D271/12 ,  C07D277/56 ,  C07D307/68 ,  C07D307/85 ,  C07D309/08 ,  C07D333/38

Abstract: The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US09974761B2

公开(公告)日：2018-05-22

申请号：US15262205

申请日：2016-09-12

Applicant: The Procter & Gamble Company

Inventor： John Christian Haught ,  Michael Reilly ,  Steven Hamilton Hoke ,  Qingxin Lei ,  Yakang Lin ,  Koti Tatachar Sreekrishna ,  Ashraf Traboulsi

IPC: A61K31/165 ,  A61K31/09 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4402 ,  A61K31/485 ,  A23G4/06 ,  A61K8/42 ,  A61K8/46 ,  A61Q5/02 ,  A61Q9/02 ,  A61Q11/00 ,  C07C233/73 ,  C07C233/75 ,  C07C237/10 ,  C07C255/44 ,  C07C323/33 ,  A61K9/00 ,  A61K9/06 ,  A61K9/28

CPC classification number: A61K31/165 ,  A23G4/06 ,  A23V2002/00 ,  A61K8/27 ,  A61K8/34 ,  A61K8/42 ,  A61K8/46 ,  A61K9/0014 ,  A61K9/0043 ,  A61K9/0078 ,  A61K9/06 ,  A61K9/28 ,  A61K31/09 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4402 ,  A61K31/485 ,  A61K2800/244 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q11/00 ,  A61Q19/00 ,  C07C233/73 ,  C07C233/75 ,  C07C237/10 ,  C07C255/44 ,  C07C323/33

Abstract: Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

公开(公告)号：US20170107173A1

公开(公告)日：2017-04-20

申请号：US15293840

申请日：2016-10-14

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： David F. Wiemer ,  Jeffrey D. Neighbors

IPC: C07C233/75 ,  C07C43/23

CPC classification number: C07C233/75 ,  C07C43/23 ,  C07C235/56 ,  C07C2601/04

Abstract: Compounds of formula I: and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating various diseases and conditions.

公开(公告)号：US09624159B2

公开(公告)日：2017-04-18

申请号：US14968423

申请日：2015-12-14

Applicant: SANOFI

Inventor： John Feutrill ,  Caroline Leriche ,  David Middlemiss

IPC: A61K31/277 ,  A61K31/216 ,  A61K31/196 ,  A61K31/165 ,  A61K31/5375 ,  A61K9/00 ,  A61K45/06 ,  C07C217/84 ,  C07C235/56 ,  C07C233/75 ,  C07C255/59 ,  C07C237/30 ,  C07C215/76 ,  C07C65/105 ,  C07C65/24 ,  C07C63/72 ,  C07C213/02 ,  C07C213/08 ,  C07C235/20 ,  C07C253/30 ,  C07C255/57 ,  C07C255/58 ,  C07D295/088

CPC classification number: C07C217/84 ,  A61K9/0014 ,  A61K9/0048 ,  A61K31/165 ,  A61K31/196 ,  A61K31/216 ,  A61K31/277 ,  A61K31/5375 ,  A61K45/06 ,  C07C63/72 ,  C07C65/105 ,  C07C65/24 ,  C07C213/02 ,  C07C213/08 ,  C07C215/76 ,  C07C233/75 ,  C07C235/20 ,  C07C235/56 ,  C07C237/30 ,  C07C253/30 ,  C07C255/57 ,  C07C255/58 ,  C07C255/59 ,  C07D295/088

Abstract: The present invention relates to therapeutic applications of aniline derivatives of formula (I), for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.

公开(公告)号：US09452170B2

公开(公告)日：2016-09-27

申请号：US14210198

申请日：2014-03-13

Applicant: The California Institute for Biomedical Research ,  The Scripps Research Institute

Inventor： Peter G. Schultz ,  Arnab K. Chatterjee ,  Shoutian Zhu ,  Joshua Payette ,  Hongchul Yoon ,  Baiyuan Yang

IPC: A61K31/165 ,  A61K31/54 ,  C07C255/60 ,  A61K31/277 ,  A61K31/192 ,  C07D295/26 ,  A61K31/5375 ,  C07D317/66 ,  A61K31/36 ,  C07D319/08 ,  C07D233/64 ,  C07D261/14 ,  A61K31/42 ,  A61K45/06 ,  A61K31/196 ,  A61K31/255 ,  A61K31/4035 ,  C07C271/20 ,  C07C275/42 ,  C07C311/05 ,  C07C311/08 ,  C07C311/13 ,  C07C311/17 ,  C07C311/21 ,  C07C311/24 ,  C07C311/46 ,  C07C317/40 ,  C07C233/66 ,  C07C233/69 ,  C07C233/73 ,  C07C233/75 ,  C07C233/76 ,  C07C233/80 ,  C07C233/81 ,  C07C233/87 ,  C07C235/52 ,  C07C235/60 ,  C07C237/22 ,  C07C251/48 ,  A61K31/18 ,  A61K31/194 ,  A61K31/24 ,  A61K31/27 ,  A61K31/357 ,  A61K31/365 ,  A61K31/402 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/495 ,  C07C235/84 ,  C07D207/27 ,  C07D209/46 ,  C07D209/48 ,  C07D213/79 ,  C07D231/40 ,  C07D277/46 ,  C07D285/135 ,  C07D307/88 ,  C07D317/28 ,  C07D319/18 ,  C12N5/077

CPC classification number: A61K31/54 ,  A61K31/18 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/24 ,  A61K31/255 ,  A61K31/27 ,  A61K31/277 ,  A61K31/357 ,  A61K31/36 ,  A61K31/365 ,  A61K31/402 ,  A61K31/4035 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06 ,  C07C233/66 ,  C07C233/69 ,  C07C233/73 ,  C07C233/75 ,  C07C233/76 ,  C07C233/80 ,  C07C233/81 ,  C07C233/87 ,  C07C235/52 ,  C07C235/60 ,  C07C235/84 ,  C07C237/22 ,  C07C251/48 ,  C07C255/60 ,  C07C271/20 ,  C07C275/42 ,  C07C311/05 ,  C07C311/08 ,  C07C311/13 ,  C07C311/17 ,  C07C311/21 ,  C07C311/24 ,  C07C311/46 ,  C07C317/40 ,  C07D207/27 ,  C07D209/46 ,  C07D209/48 ,  C07D213/79 ,  C07D231/40 ,  C07D233/64 ,  C07D261/14 ,  C07D277/46 ,  C07D285/135 ,  C07D295/26 ,  C07D307/88 ,  C07D317/28 ,  C07D317/66 ,  C07D319/08 ,  C07D319/18 ,  C12N5/0655 ,  C12N2506/1353 ,  A61K2300/00

Abstract: Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes.

Abstract translation: 本文描述了通过将间充质干细胞诱导成软骨细胞来改善关节炎或关节损伤的化合物和组合物。

公开(公告)号：US20160272554A1

公开(公告)日：2016-09-22

申请号：US15033323

申请日：2014-11-03

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

Inventor： PRAGATI KISHORE PRASAD ,  ARUMUGAM SUDALAI

IPC: C07B41/12 ,  C07D491/052 ,  C07D311/10 ,  C07B43/06 ,  C07D307/89 ,  C07D209/48 ,  C07D209/46 ,  C07D311/76 ,  C07D307/88

CPC classification number: C07B41/12 ,  C07B43/06 ,  C07C51/00 ,  C07C67/00 ,  C07C201/12 ,  C07C231/10 ,  C07C231/12 ,  C07D209/46 ,  C07D209/48 ,  C07D307/88 ,  C07D307/89 ,  C07D311/10 ,  C07D311/76 ,  C07D491/052 ,  C07C63/06 ,  C07C69/92 ,  C07C69/78 ,  C07C233/66 ,  C07C205/56 ,  C07C205/57 ,  C07C233/65 ,  C07C233/75

Abstract: The present invention discloses one-pot synthesis of various carboxylic acid derivatives using copper catalyst and sodium cyanide as the cyanide source for bringing in carbonylative coupling in a single step.

Abstract translation: 本发明公开了使用铜催化剂和氰化钠作为一步进行羰基偶联的氰化物源的各种羧酸衍生物的一锅合成。

公开(公告)号：US20160058761A1

公开(公告)日：2016-03-03

申请号：US14934715

申请日：2015-11-06

Applicant: Michael G. Natchus ,  Richard Arrendale ,  Dennis Liotta

Inventor： Michael G. Natchus ,  Richard Arrendale ,  Dennis Liotta

IPC: A61K31/506 ,  A61K45/06

CPC classification number: A61K31/506 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/444 ,  A61K31/505 ,  A61K31/57 ,  A61K31/575 ,  A61K31/58 ,  A61K38/2073 ,  A61K45/06 ,  C07C211/27 ,  C07C211/52 ,  C07C211/53 ,  C07C229/60 ,  C07C233/11 ,  C07C233/58 ,  C07C233/64 ,  C07C233/65 ,  C07C233/75 ,  C07C237/40 ,  C07C255/58 ,  C07C279/04 ,  C07C279/18 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  A61K2300/00

Abstract: The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

Abstract translation: 本公开提供了可用于治疗某些内分泌紊乱症状的某些化合物的使用方法，特别是与潮热相关的化合物。

公开(公告)号：US09193845B2

公开(公告)日：2015-11-24

申请号：US14492554

申请日：2014-09-22

Applicant: MILLIKEN & COMPANY

Inventor： Haihu Qin ,  Darin L. Dotson ,  Eduardo Torres ,  Sanjeev K. Dey ,  Francisco Alvarez

IPC: C08K5/20 ,  C08K5/00 ,  C07C233/81 ,  C07C233/64 ,  C07C235/56 ,  C07C233/63 ,  C07C233/65 ,  C07C233/66 ,  C07C233/75 ,  C07C233/87

CPC classification number: C08K5/20 ,  C07C233/63 ,  C07C233/64 ,  C07C233/65 ,  C07C233/66 ,  C07C233/75 ,  C07C233/81 ,  C07C233/87 ,  C07C235/56 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C08K5/0083

Abstract: The invention provides a compound conforming to the structure of Formula (CX) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CX) as a nucleating agent.

Abstract translation: 本发明提供符合式（CX）结构的化合物。本发明还提供一种包含聚烯烃聚合物和符合式（CX）结构的化合物作为成核剂的热塑性聚合物组合物。

公开(公告)号：US20150307443A1

公开(公告)日：2015-10-29

申请号：US14650159

申请日：2013-12-05

Applicant: BARUCH S. BLUMBERG INSTITUTE ,  DREXEL UNIVERSITY

Inventor： XIAODONG XU ,  TIMOTHY M. BLOCK ,  JU-TAO GUO ,  YANMING DU

IPC: C07C233/66 ,  C07D495/04 ,  C07D321/10 ,  C07D319/18 ,  C07D317/46 ,  C07D333/72 ,  C07D333/68

CPC classification number: C07C233/66 ,  C07C233/75 ,  C07C235/64 ,  C07C2602/10 ,  C07D317/46 ,  C07D317/68 ,  C07D319/18 ,  C07D321/10 ,  C07D333/68 ,  C07D333/70 ,  C07D333/72 ,  C07D495/04

Abstract: Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as pregenomic RNA encapsidation inhibitors, and are useful for the treatment of Hepatitis B virus (HBV) infection.

Abstract translation: 本发明的药物组合物包含可用作前基因组RNA包封抑制剂的官能化苯甲酰胺衍生物，并且可用于治疗乙型肝炎病毒（HBV）感染。