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    Ergoline amine derivatives with blood pressure lowering effect
    2.
    发明授权
    Ergoline amine derivatives with blood pressure lowering effect 失效
    艾曲林胺衍生物具有降血压作用

    公开(公告)号：US06358967B1

    公开(公告)日：2002-03-19

    申请号：US09743869

    申请日：2001-04-19

    Applicant: Ralf Wyrwa ,  Albert Haertl ,  Erika Glusa ,  Susanne Grabley ,  Ralf Thiericke

    Inventor： Ralf Wyrwa ,  Albert Haertl ,  Erika Glusa ,  Susanne Grabley ,  Ralf Thiericke

    IPC: A61K3148

    CPC classification number: C07F15/025 ,  C07D457/02 ,  C07F17/02

    Abstract: The invention relates to novel derivatives of ergoline of the general formula 1 in which R1 together with the two adjacent N atoms is the residue of a diamine and R4 together with the two adjacent carbonyl groups is the residue of a dicarboxylic acid. R2, R3, R6, R7, R8 can be H or an organic radical. R7 and R8 are H or together are a bond. The compounds show a strong antihypertensive effect. These effects moreover occur after intravenous and enteral administration even at dosages in the region of a few &mgr;g/kg (body weight). The compounds can accordingly be used as pharmaceuticals for hypertensive diseases in human medicine.

    Abstract translation: 本发明涉及通用1的麦角灵素的新衍生物，其中R1与两个相邻的N原子一起是二胺的残基，R4与两个相邻的羰基一起是二羧酸的残基。 R2，R3，R6，R7，R8可以是H或有机基团。 R7和R8是H或一起是一个键。化合物显示出强烈的抗高血压作用。 即使在几公斤/公斤（体重）的剂量下，静脉内和肠内给药也会发生这些影响。 因此，这些化合物可以用作人类医学中的高血压疾病的药物。

    Protected forms of pharmacologically active agents and uses therefor
    4.
    发明授权
    Protected forms of pharmacologically active agents and uses therefor 有权
    保护形式的药理活性剂及其用途

    公开(公告)号：US06355666B1

    公开(公告)日：2002-03-12

    申请号：US09602688

    申请日：2000-06-23

    Applicant: Ching-San Lai ,  Tingmin Wang

    Inventor： Ching-San Lai ,  Tingmin Wang

    IPC: A61K3148

    CPC classification number: A61K47/555 ,  A61K47/54

    Abstract: In accordance with the present invention, there are provided normal modified forms of nonsteroidal anti-inflammatory drugs. Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provide the therapeutic benefits of NSAIDs while causing a much lower incidence of side-effects then typically observed with such agents.

    Abstract translation: 根据本发明，提供了非甾体抗炎药的正常修饰形式。 根据本发明的修饰的NSAID提供了一类新的抗炎剂，其提供NSAIDs的治疗益处，同时引起副作用的发生率低得多，然后通常用这些药剂观察到。

    Crystalline form II cabergoline
    6.
    发明授权
    Crystalline form II cabergoline 失效
    晶型II卡麦角林

    公开(公告)号：US06673806B2

    公开(公告)日：2004-01-06

    申请号：US10239562

    申请日：2003-01-16

    Applicant: Attilio Tomasi ,  Stefania Magenes ,  Giuliano Ramella ,  Mario Ungari ,  Marco Pandolfi

    Inventor： Attilio Tomasi ,  Stefania Magenes ,  Giuliano Ramella ,  Mario Ungari ,  Marco Pandolfi

    IPC: A61K3148

    CPC classification number: C07D457/06

    Abstract: Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline Forms I and II in a solvent at a temperature below about 30° C.

    Abstract translation: 公开了卡麦角林的结晶形式II，含有它的药物组合物及其制备方法。 该方法可以包括在低温下从原料卡麦角林在有机溶剂中的溶液结晶，或者在低于约30℃的温度下在溶剂中将卡麦角林I型和II型混合物悬浮在浆液程序中。

    Modified forms of pharmacologically active agents and uses therefor
    7.
    发明授权
    Modified forms of pharmacologically active agents and uses therefor 失效
    药理活性剂的修饰形式及其用途

    公开(公告)号：US06429223B1

    公开(公告)日：2002-08-06

    申请号：US09715767

    申请日：2000-11-17

    Applicant: Ching-San Lai ,  Tingmin Wang

    Inventor： Ching-San Lai ,  Tingmin Wang

    IPC: A61K3148

    CPC classification number: A61K47/555 ,  A61K47/54 ,  A61K47/545

    Abstract: In accordance with the present invention, there are provided modified forms of nonsteroidal anti-inflammatory drugs (NSAIDs). Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provide the therapeutic benefits of NSAIDs while causing a much lower incidence of side-effects then typically observed with such agents.

    Abstract translation: 根据本发明，提供非甾体抗炎药（NSAID）的修饰形式。 根据本发明的修饰的NSAID提供了一类新的抗炎剂，其提供NSAIDs的治疗益处，同时引起副作用的发生率低得多，然后通常用这些药剂观察到。

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