-
公开(公告)号：US06214799B1
公开(公告)日：2001-04-10
申请号：US09226205
申请日：1999-01-07
申请人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
发明人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
IPC分类号： C07D36348
CPC分类号： C07K5/06139 , C07C237/22 , C07K5/0202 , C07K5/0205 , C07K5/06052
摘要： Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
摘要翻译： 通过化学合成获得的微小RNA病毒3C蛋白酶抑制剂抑制或阻断小核糖核酸病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物适用于治疗感染了一种或多种微小核糖核酸病毒的患者或宿主。 可以使用几种新的方法和中间体来制备本发明的新型微核糖核酸病毒3C蛋白酶抑制剂。
-
公开(公告)号：US06362166B1
公开(公告)日：2002-03-26
申请号：US09689717
申请日：2000-10-13
申请人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
发明人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
IPC分类号： A61K3148
CPC分类号： C07K5/06139 , C07C237/22 , C07K5/0202 , C07K5/0205 , C07K5/06052
摘要： Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
摘要翻译： 通过化学合成获得的微小RNA病毒3C蛋白酶抑制剂抑制或阻断小核糖核酸病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物适用于治疗感染了一种或多种微小核糖核酸病毒的患者或宿主。 可以使用几种新的方法和中间体来制备本发明的新型微核糖核酸病毒3C蛋白酶抑制剂。
-
公开(公告)号：US5885996A
公开(公告)日：1999-03-23
申请号：US923117
申请日：1997-09-04
IPC分类号： A61K31/505 , A61K31/517 , A61P31/04 , A61P31/10 , A61P35/00 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/93 , C07D239/95 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/12 , A61K31/54 , C07D403/02
CPC分类号： C07D401/12 , C07D239/90 , C07D239/93 , C07D239/95 , C07D403/06 , C07D403/12 , C07D417/12 , Y10S514/895 , Y10S514/896 , Y10S514/898
摘要： Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
摘要翻译： 显示抗增殖活性的喹唑啉化合物，例如抗肿瘤活性，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物的用途。 这些化合物抑制细菌，酵母和真菌等高等生物和微生物细胞的生长和增殖。 优选的喹唑啉化合物能够抑制胸苷酸合酶的酶。 由抑制酶胸苷酸合酶导致的效果包括上述讨论。
-
公开(公告)号：US5856530A
公开(公告)日：1999-01-05
申请号：US850398
申请日：1997-05-02
申请人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
发明人： Stephen E. Webber , Peter S. Dragovich , Thomas J. Prins , Siegfried H. Reich , Thomas L. Little, Jr. , Ethel S. Littlefield , Joseph T. Marakovits , Robert E. Babine , Ted M. Bleckman
IPC分类号： C07C237/22 , C07K5/02 , C07K5/06 , C07K5/078 , C07D307/12 , C07C69/74 , C07C69/757 , C07D307/10
CPC分类号： C07K5/06139 , C07C237/22 , C07K5/0202 , C07K5/0205 , C07K5/06052
摘要： Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
-
公开(公告)号：US5430148A
公开(公告)日：1995-07-04
申请号：US861030
申请日：1992-03-31
IPC分类号： A61K31/505 , A61K31/517 , A61P31/04 , A61P31/10 , A61P35/00 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/93 , C07D239/95 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/12
CPC分类号： C07D401/12 , C07D239/90 , C07D239/93 , C07D239/95 , C07D403/06 , C07D403/12 , C07D417/12 , Y10S514/895 , Y10S514/896 , Y10S514/898
摘要： Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
摘要翻译： 显示抗增殖活性的喹唑啉化合物，例如抗肿瘤活性，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物的用途。 这些化合物抑制细菌，酵母和真菌等高等生物和微生物细胞的生长和增殖。 优选的喹唑啉化合物能够抑制胸苷酸合酶的酶。 由抑制酶胸苷酸合酶导致的效果包括上述讨论。
-
6.发明授权(4-oxo-2-pyrimidinyl)thioalkyl compounds useful as AICARFT inhibitors 失效（4-氧代-2-嘧啶基）硫代烷基化合物用作AICARFT抑制剂公开(公告)号：US06525050B1
公开(公告)日：2003-02-25
申请号：US09786109
申请日：2001-03-01
IPC分类号： C07D23902
CPC分类号： C07D409/14 , C07D409/12
摘要： Compounds of the formula: (where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.
摘要翻译： 下式的化合物（其中R1，R2和R3在说明书中定义）是AICARFT的抑制剂。 这些化合物及其药学上可接受的盐，溶剂，前药和药物活性代谢物可用于治疗诸如癌症的疾病的药物组合物中。
-
公开(公告)号：US5707992A
公开(公告)日：1998-01-13
申请号：US418415
申请日：1995-04-07
IPC分类号： A61K31/505 , A61K31/517 , A61P31/04 , A61P31/10 , A61P35/00 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/93 , C07D239/95 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/12
CPC分类号： C07D401/12 , C07D239/90 , C07D239/93 , C07D239/95 , C07D403/06 , C07D403/12 , C07D417/12 , Y10S514/895 , Y10S514/896 , Y10S514/898
摘要： Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.019 秒)
