公开(公告)号：US5904915A

公开(公告)日：1999-05-18

申请号：US825049

申请日：1997-03-27

申请人： Yasuhisa Fujibayashi ,  Atsuo Waki ,  Akira Yokoyama

发明人： Yasuhisa Fujibayashi ,  Atsuo Waki ,  Akira Yokoyama

IPC分类号： C07H13/04 ,  C12Q1/54 ,  A61K51/06 ,  A61K51/04 ,  G01N33/00 ,  A61N57/00

CPC分类号： C07H13/04 ,  C12Q1/54 ,  Y10T436/104998 ,  Y10T436/144444

摘要： A diagnostic agent for glycometabolic function comprising a glucose derivative of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents hydrogen or acyl having 2 to 8 carbon atoms, with the proviso that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is acyl and R.sup.5 represents X or --NHCOR.sup.6 X wherein X is a radioisotope of halogen and R.sup.6 is arylene or alkylene having 1 to 3 carbon atoms.

摘要翻译： 一种糖代谢功能的诊断剂，其包含式（I）的葡萄糖衍生物：其中R 1，R 2，R 3和R 4相同或不同，各自表示氢或具有2至8个碳原子的酰基，条件是至少一个 的R 1，R 2，R 3和R 4是酰基，R 5表示X或-NHCOR 6 X，其中X是卤素的放射性同位素，R 6是亚芳基或具有1至3个碳原子的亚烷基。

公开(公告)号：US07109314B2

公开(公告)日：2006-09-19

申请号：US09829467

申请日：2001-04-09

申请人： Hiroshi Shinoki ,  Hiroko Inomata ,  Masayoshi Kojima ,  Yukio Sudo ,  Osamu Seshimoto

发明人： Hiroshi Shinoki ,  Hiroko Inomata ,  Masayoshi Kojima ,  Yukio Sudo ,  Osamu Seshimoto

IPC分类号： C07H21/02 ,  C12Q1/68 ,  A61N57/00

CPC分类号： C07H21/00

摘要： According to the present invention, there is provided a fluorescent nucleotide represented by the formula: A-B-C,wherein A represents a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue; B represents a divalent linking group or a single bond; and C represents a monovalent group derived from a fluorescent dye having 0 or 1 sulfonic acid group or phosphoric acid group in a molecule. The present invention provides useful fluorescent nucleotides for labeling nucleic acids, specifically, fluorescent nucleotides of which uptake ratio is high in synthetic reaction of nucleic acids.