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公开(公告)号：US20020127246A1
公开(公告)日：2002-09-12
申请号：US10079534
申请日：2002-02-22
IPC分类号： A61K048/00 , A61K039/245
摘要： Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment, inoculating a tumor in the patient with a pharmaceutical composition consisting essentially of (A) a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells and (B) a pharmaceutically acceptable vehicle for the virus, such that an immune response is induced that is specific for the tumor cell type and that kills cells of the inoculated tumor and of a non-inoculated tumor. In another embodiment, the pharmaceutical composition also comprises a defective HSV vector which contains an expressible nucleotide sequence encoding at least one immune modulator. In another embodiment, the pharmaceutical composition contains a second HSV that infects tumor cells but that does not spread in normal cells. According to the latter approach, both the first HSV and the second HSV may have genomes that comprise, respectively, an expressible nucleotide sequence coding for at least one immune modulator. In another embodiment, the pharmaceutical composition comprises, in addition to a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells, a viral vector comprising at least one expressible nucleotide sequence coding for at least one immune modulator.
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公开(公告)号：US20240296692A1
公开(公告)日：2024-09-05
申请号：US18662435
申请日：2024-05-13
发明人： Cristopher Flagg , Ophir Frieder
IPC分类号： G06V30/418 , G06F16/55 , G06F16/56 , G06T17/00 , G06V10/764 , G06V10/82 , G06V40/16
CPC分类号： G06V30/418 , G06F16/55 , G06F16/56 , G06T17/00 , G06V10/764 , G06V10/82 , G06V40/169 , G06T2200/04 , G06T2200/08
摘要： Technologies are described for reconstructing facial models which are preserved images or images captured from security cameras. The reconstructed models can be three-dimensional (3D) point clouds and can be compared to existing facial models and/or other reconstructed models based on physical geometry. The 3D point cloud models can be encoded into one or more latent space feature vector representations which can allow both local and global geometric properties of a face to be described. The one or more feature vector representations of a target face can be used individually or in combination with other descriptors for recognition, retrieval, and classification tasks. Neural networks can be used in the encoding of the one or more feature vector representations.
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公开(公告)号：US12073646B2
公开(公告)日：2024-08-27
申请号：US17716859
申请日：2022-04-08
发明人： Cristopher Flagg , Ophir Frieder
IPC分类号： G06V30/418 , G06F16/55 , G06F16/56 , G06T17/00 , G06V10/764 , G06V10/82 , G06V40/16
CPC分类号： G06V30/418 , G06F16/55 , G06F16/56 , G06T17/00 , G06V10/764 , G06V10/82 , G06V40/169 , G06T2200/04 , G06T2200/08
摘要： Technologies are described for reconstructing physical objects which are preserved or represented in pictorial records. The reconstructed models can be three-dimensional (3D) point clouds and can be compared to existing physical models and/or other reconstructed models based on physical geometry. The 3D point cloud models can be encoded into one or more latent space feature vector representations which can allow both local and global geometric properties of the object to be described. The one or more feature vector representations of the object can be used individually or in combination with other descriptors for retrieval and classification tasks. Neural networks can be used in the encoding of the one or more feature vector representations.
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94.发明公开公开(公告)号：US20240252696A1
公开(公告)日：2024-08-01
申请号：US17925582
申请日：2021-05-26
申请人： Georgetown University , The USA as represented by the Secretary, Department of Health and Human Services
发明人： Jill P. Smith , Stephan Stern
CPC分类号： A61K51/088 , A61K49/0056
摘要： A method that includes detecting the presence of a pancreatic intraepithelial neoplasia lesion in a subject in vivo comprising administering to the subject a construct, or a pharmaceutically acceptable salt thereof, wherein the construct comprises:
(a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized;
(b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and
(c) a detectable moiety complexed with, or conjugated to, the poly(L-lysine) of the polymer moiety,
wherein the construct is neutralized.-
公开(公告)号：US20240248028A1
公开(公告)日：2024-07-25
申请号：US18554405
申请日：2022-02-09
摘要： An analytical method is disclosed that includes the steps of: providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms; providing a probe selected from the group consisting of quinones and analogs thereof, (hetero)aryl isocyanates and analogs thereof, and (hetero)aryl isothiocyanates and analogs thereof; contacting the sample with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and determining, based on any binding that occurs, the absolute configuration of the analyte in the sample and/or the concentration of the analyte in the sample and/or the enantiomeric and/or the diastereomeric composition of the analyte in the sample.
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公开(公告)号：US12020497B2
公开(公告)日：2024-06-25
申请号：US17716874
申请日：2022-04-08
发明人： Cristopher Flagg , Ophir Frieder
IPC分类号： G06T17/00 , G06F16/55 , G06F16/56 , G06V10/764 , G06V10/82 , G06V30/418 , G06V40/16
CPC分类号： G06V30/418 , G06F16/55 , G06F16/56 , G06T17/00 , G06V10/764 , G06V10/82 , G06V40/169 , G06T2200/04 , G06T2200/08
摘要： Technologies are described for reconstructing facial models which are preserved images or images captured from security cameras. The reconstructed models can be three-dimensional (3D) point clouds and can be compared to existing facial models and/or other reconstructed models based on physical geometry. The 3D point cloud models can be encoded into one or more latent space feature vector representations which can allow both local and global geometric properties of a face to be described. The one or more feature vector representations of a target face can be used individually or in combination with other descriptors for recognition, retrieval, and classification tasks. Neural networks can be used in the encoding of the one or more feature vector representations.
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97.发明公开公开(公告)号：US20240115670A1
公开(公告)日：2024-04-11
申请号：US18263129
申请日：2022-01-27
CPC分类号： A61K38/4813 , A61K38/195 , A61K39/4611 , A61K39/4613 , A61K39/4631 , A61P35/00
摘要： Systems and methods are disclosed for the treatment of cancer. Specifically, techniques are disclosed for treating cancer through the administration of genetically modified immune cells that overexpress fibroblast activation protein. In other embodiments, the techniques include the treatment of cancer through the administration of fibroblast activation protein inhibitors to the tumor site.
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公开(公告)号：US11951167B2
公开(公告)日：2024-04-09
申请号：US17168614
申请日：2021-02-05
发明人： Esther H. Chang , SangSoo Kim , Antonina Rait
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/1271 , A61K9/1272
摘要： The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors. In still other embodiments the liposomes can deliver other drugs such as pemetrexed or irinotecan for treatment of cancer or drugs including atropine for treatment of organophosphate poisoning.
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公开(公告)号：US20240092800A1
公开(公告)日：2024-03-21
申请号：US18260721
申请日：2022-01-14
发明人： Charbel MOUSSA , Christian WOLF , Balaraman KALUVU
IPC分类号： C07D495/04 , A61K45/06 , A61P25/28 , C07D215/233 , C07D215/44 , C07D311/68
CPC分类号： C07D495/04 , A61K45/06 , A61P25/28 , C07D215/233 , C07D215/44 , C07D311/68
摘要： Novel ubiquitin specific protease 13 (USP13) inhibitors are provided, along with methods for their use. The USP13 inhibitors described herein are useful in treating and/or preventing USP13-related diseases, such as neurodegenerative diseases and cancer. Also provided are methods for inhibiting USP13 in a cell using the compounds and compositions described herein.
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100.发明公开公开(公告)号：US20240058421A1
公开(公告)日：2024-02-22
申请号：US18486302
申请日：2023-10-13
发明人： Christopher ALBANESE , Aisha NAEEM
IPC分类号： A61K38/22 , A61P35/00 , A61K31/475 , A61K31/704
CPC分类号： A61K38/2292 , A61P35/00 , A61K31/475 , A61K31/704
摘要： Provided herein is a method of treating medulloblastoma or glioblastoma in a subject by administering to the subject a PI3K activator (e.g., thymosin β-4 or a derivative thereof) and one or more chemotherapeutic agents and/or radiation. The combination therapy is effective in the treatment of medulloblastoma or glioblastoma characterized by cells with elevated p53 levels.
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