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公开(公告)号：US20240248033A1
公开(公告)日：2024-07-25
申请号：US18417471
申请日：2024-01-19
申请人： Academia Sinica
发明人： Chia-Fu CHOU , Pei-Kuen WEI , Liang-Kun YU , Deng-Kai YANG , Jui-Hong WENG , Kuang-Li LEE , Shu-Cheng LO
IPC分类号： G01N21/552 , B82Y15/00 , G01N21/19 , G01N21/25
CPC分类号： G01N21/554 , B82Y15/00 , G01N21/19 , G01N2021/258 , G01N2201/0633
摘要： A surface plasmon resonance sensor is provided, which comprises: a substrate; an adaptation layer disposed on the substrate and comprising a dielectric material; and a metal layer disposed on the adaptation layer, wherein the metal layer has a grating structure comprising plural metal lines. Furthermore, a surface plasmon resonance sensing instrument comprising the same and a method for detecting an analyte using the same are also provided.
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公开(公告)号：US20240248028A1
公开(公告)日：2024-07-25
申请号：US18554405
申请日：2022-02-09
摘要： An analytical method is disclosed that includes the steps of: providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms; providing a probe selected from the group consisting of quinones and analogs thereof, (hetero)aryl isocyanates and analogs thereof, and (hetero)aryl isothiocyanates and analogs thereof; contacting the sample with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and determining, based on any binding that occurs, the absolute configuration of the analyte in the sample and/or the concentration of the analyte in the sample and/or the enantiomeric and/or the diastereomeric composition of the analyte in the sample.
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公开(公告)号：US12007276B2
公开(公告)日：2024-06-11
申请号：US16362598
申请日：2019-03-22
CPC分类号： G01J3/0237 , G01J3/2803 , G01J3/44 , G01N21/19 , G01N21/251
摘要： A spectroscopic microscope device, including at least one array of metasurfaces, and at least one CCD array integrated with the array of metasurfaces. The metasurfaces in the array are configured to separately direct LCP an RCP components of light incident on the metasurface to separate pixels in the CCD array.
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4.发明授权公开(公告)号：US11119033B2
公开(公告)日：2021-09-14
申请号：US12385856
申请日：2009-04-22
申请人： Hiroshi Izumi , Atsushi Ogata , Kazuyuki Takeo , Hideki Kobayashi
发明人： Hiroshi Izumi , Atsushi Ogata , Kazuyuki Takeo , Hideki Kobayashi
摘要： A conformation analysis device and analysis method with which discrimination can be achieved even if there is a subtle difference in a conformational structure, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, and a conformational notation device and notation method with which even in the case where a conformation cannot be uniquely determined if a rule in accordance with the IUPAC Nomenclature is followed, the conformation can be uniquely notated, a given molecule can be processed in a unified manner, and large-scale computer processing can be performed, are provided. In one embodiment of the invention, a processing section receives an input of a chemical structural formula of a compound to be analyzed, puts a predetermined code indicating a dihedral angle to each chemical binding site based on the received chemical structural formula, extracts an encoded conformational notation of interest with respect to a structure capable of uniquely determining a conformation with one conformational notation, and stores the extracted encoded conformational notation in a storage section. Then, the processing section creates a molecular model based on the extracted encoded conformational notation, performs geometry optimization and frequency calculation for the created molecular model, determines a geometry optimized structure and a physical property value of the geometry optimized structure, extracts the encoded conformational notation from the storage section, and performs a homology analysis based on the notation.
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公开(公告)号：US20210190676A1
公开(公告)日：2021-06-24
申请号：US16770219
申请日：2018-11-29
发明人： Kodai MURAYAMA , Atsushi ITO , Fumie WATANABE
摘要： A spectroscopic analysis device includes a light source configured to emit light including a plurality of wavelength components, a polarizer configured to convert the light emitted from the light source to a light of linearly polarized light to be radiated to a sample, a polarizing diffraction element configured to diffract and spectrally disperse a first polarization component included in the light having passed through the sample in a first direction, the polarizing diffraction element being configured to diffract and spectrally disperse a second polarization component included in the light in a second direction different from the first direction, a prism which is disposed on an exit side of the polarizing diffraction element and which has a first exit surface crossing the first direction and a second exit surface crossing the second direction, and in which angles of the first exit surface and the second exit surface with respect to a reference plane including the first direction and the second direction are different, an imaging element configured to capture an image of the first polarization component emitted from the first exit surface of the prism and an image of the second polarization component emitted from the second exit surface, and a processor configured to analyze the sample based on an imaging result of the imaging element.
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公开(公告)号：US10989651B2
公开(公告)日：2021-04-27
申请号：US15314034
申请日：2015-05-28
发明人： Timothy Dafforn , Matthew Hicks
IPC分类号： G01N21/19 , G01N21/05 , G01N21/21 , C12Q1/6825 , G01N33/569
摘要： A molecular sensor that utilises dichroism can be used to identify the presence of specific molecules in a substance. The molecular sensor includes a sensor element comprising (i) a scaffold moiety and (ii) one or more receptor molecules for the target molecule attached to the scaffold moiety to form a scaffold/receptor complex, wherein the scaffold/receptor complex is modified to incorporate a chromophore and the modified scaffold/receptor complex has a high aspect ratio.
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公开(公告)号：US10718708B2
公开(公告)日：2020-07-21
申请号：US16091531
申请日：2017-04-04
IPC分类号： G01J3/447 , G01N21/3586 , G01N21/19 , G01N21/21 , A61F2/08 , A61F2/46 , A61L27/36 , G01N33/483 , A61F2/30
摘要： An object is to provide a technique that can evaluate biological tissues such as cartilage tissue and regenerated tissues such as regenerated cartilage. A method for observing a dynamic physical property of a biological tissue according to the present invention is that a biological tissue is irradiated with a pulsed light having a wavelength of a far-infrared wavelength region modulated into circular polarized lights by applying bias voltages to a radiation means (3) having an antenna electrode films of orthogonal (2)-axis structure with phases shifted using high-voltage high-speed modulation means (13), and dynamic physical property of the biological tissue is observed on the basis of a spectrum obtained by vibration optical activity spectroscopy.
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公开(公告)号：US10663391B2
公开(公告)日：2020-05-26
申请号：US16414253
申请日：2019-05-16
发明人： Hiroshi Satozono
摘要： Circular dichroism can be accurately measured even when a phase modulation element with a distortion component is used.A circular dichroism measuring method using a circular dichroism measuring device 2 includes a step of measuring Ip(t) (S101: phase amount change acquisition step), a step of measuring Is(t) (S102: sample data acquisition step), a step of converting Ip(t) to δ(t) (S103: phase amount change acquisition step), a step of converting Is(t) to Is(δ) (S104: analysis step/Is(δ) calculation step), and a step of performing curve fitting to calculate matrix elements S00, S02, and S03 (S105: analysis step/matrix element calculation step).
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公开(公告)号：US10564035B2
公开(公告)日：2020-02-18
申请号：US15968307
申请日：2018-05-01
申请人： JASCO Corporation
发明人： Yoshiro Kondo , Koshi Nagamori
摘要： The present invention relates to improvement in accuracy in a device and a method for determining whether a spectrum of a target sample coincide with a standard spectrum or not.A spectrum determination device 10 determines whether a sample spectrum coincides with a reference spectrum or not by the reference spectrum obtained from a spectrum group. The spectrum determination device 10 comprises a storage unit 26 for storing the reference spectrum, and a determination unit 28 for comparing the reference spectrum and the sample spectrum to determine a sample 20 from the comparison result. The reference spectrum is set with a differing weighting for each point. The determination unit 28 calculates an individual coincidence with the sample spectrum for each point of the reference spectrum, and calculates a coincidence of the sample spectrum with the reference spectrum by the individual coincidence and the differing weighting to determine the sample 20.
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公开(公告)号：US20190271639A1
公开(公告)日：2019-09-05
申请号：US16414253
申请日：2019-05-16
发明人： Hiroshi SATOZONO
摘要： Circular dichroism can be accurately measured even when a phase modulation element with a distortion component is used.A circular dichroism measuring method using a circular dichroism measuring device 2 includes a step of measuring Ip(t) (S101: phase amount change acquisition step), a step of measuring Is(t) (S102: sample data acquisition step), a step of converting Ip(t) to δ(t) (S103: phase amount change acquisition step), a step of converting Is(t) to Is(δ) (S104: analysis step/Is(δ) calculation step), and a step of performing curve fitting to calculate matrix elements S00, S02, and S03 (S105: analysis step/matrix element calculation step).
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