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    Intraocular lens insertion device
    91.
    发明授权
    Intraocular lens insertion device 有权

    公开(公告)号：US09855138B2

    公开(公告)日：2018-01-02

    申请号：US14648119

    申请日：2013-11-29

    Applicant: KOWA COMPANY, LTD.

    Inventor： Kenichi Kobayashi

    IPC: A61F2/16 ,  A61F9/00

    CPC classification number: A61F2/167 ,  A61F2/1678

    Abstract: The intraocular lens insertion tool includes a nozzle main body having a nozzle portion 15, a stage portion capable of disposing the intraocular lens 2 in the nozzle main body, and a plunger 60 that presses the intraocular lens 2 set in the stage portion by a leading end, thereby releasing the intraocular lens 2 into an eyeball. The leading end portion 10a of the nozzle portion 15 is obliquely cut so that, as it goes to the front side from the optical axis rear side of intraocular lens 2, the position of the end surface is located on the front side, and at the leading end 61d of the plunger 60, a protruding portion 61e is provided which protrudes to the front side so as to be able to place the surface of the optical axis rear side of the intraocular lens 2.

    PHARMACEUTICAL PRODUCT
    94.
    发明申请
    PHARMACEUTICAL PRODUCT 审中-公开

    公开(公告)号：US20170266080A1

    公开(公告)日：2017-09-21

    申请号：US15514020

    申请日：2015-09-25

    Applicant: KOWA COMPANY, LTD.

    Inventor： Shin SUGIMOTO

    IPC: A61J1/14 ,  A61K9/08 ,  A61K31/551

    CPC classification number: A61J1/1468 ,  A61K9/08 ,  A61K31/551

    Abstract: A technique is provided for suppressing discoloration of an aqueous composition containing a halogenated isoquinoline derivative during preservation at high temperature. A pharmaceutical preparation obtained by storing an aqueous composition comprising a compound represented by Formula (1), wherein X represents a halogen atom, or a salt thereof, or a solvate of the compound or the salt thereof, in a container made of polyolefin-based resin.

    MEDICINE
    95.
    发明申请
    MEDICINE 审中-公开

    公开(公告)号：US20170252338A1

    公开(公告)日：2017-09-07

    申请号：US15528630

    申请日：2015-11-27

    Applicant: KOWA COMPANY, LTD.

    Inventor： Haruki SHIBATA

    IPC: A61K31/505 ,  A61K31/47

    CPC classification number: A61K31/505 ,  A61K31/47 ,  A61K45/00

    Abstract: A medicine for lowering LDL cholesterol is provided. A medicine for lowering LDL cholesterol, the medicine comprising a combination of a statin and (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl) ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, a salt thereof, or a solvate of the compound or the salt.

    Method for improving optical purity of 2-hydroxycarboxylic acid or derivative thereof
    96.
    发明授权
    Method for improving optical purity of 2-hydroxycarboxylic acid or derivative thereof 有权

    公开(公告)号：US09682913B2

    公开(公告)日：2017-06-20

    申请号：US14780625

    申请日：2014-03-28

    Applicant: KOWA COMPANY, LTD.

    Inventor： Yukiyoshi Yamazaki

    IPC: C07B57/00 ,  C07C51/41 ,  A61K31/423 ,  C07D263/58 ,  C07C67/08

    CPC classification number: C07C51/412 ,  A61K31/423 ,  C07B57/00 ,  C07C67/08 ,  C07D263/58 ,  C07C51/487 ,  C07C59/01

    Abstract: To provide a method for improving optical purity of an optically active 2-hydroxycarboxylic acid or a derivative thereof, which is useful as a raw material in the manufacture of medicines, agrochemicais, and industrial products. The method of the invention for improving purity of a hydroxycarboxylic acid of the following formula (1a) or (1b) or a derivative thereof includes the steps of reacting the hydroxycarboxylic acid of the following formula (1a) or (1b) with at least one optically inactive base selected from the group consisting of an alkali metal, alkoxide and a secondary amine in the presence of a solvent and, subsequently, performing recrystallization, to thereby form a hydroxycarboxylic acid salt of the following formula (IIIa) or (IIIb): wherein R1 represents a C1-8 alkyl group, and R2 represents an alkali metal or a secondary amine.

    Intraocular lens
    97.
    发明授权
    Intraocular lens 有权

    公开(公告)号：US09681943B2

    公开(公告)日：2017-06-20

    申请号：US14913075

    申请日：2014-09-02

    Applicant: KOWA COMPANY, LTD.

    Inventor： Yutaka Kumazawa ,  Kotaro Sakanishi ,  Atsushi Kobayashi

    IPC: A61F2/16

    CPC classification number: A61F2/16 ,  A61F2/1613 ,  A61F2002/1683 ,  A61F2002/169 ,  A61F2002/16901

    Abstract: An intraocular lens wherein an outer edge of a support part has a curved concave shape at a base thereof and extends therefrom toward a tip thereof with a curved convex shape having a radius of curvature of 5.25 to 7.50 mm. In a region where a Y coordinate of an orthogonal coordinate system is 1.0 mm or greater, an origin of the coordinate system being a geometric center of an optical part, an inner edge of the support part is positioned between shapes obtained by offsetting the outer edge of the support part by 0.2 mm and by 1.0 mm towards the X-axis origin. The tip of the support part is positioned in a region where the Y coordinate is greater than a radius of the optical part, outside a circle with a radius of 5.0 mm centered on the origin.

    SUPPORTER
    98.
    发明申请
    SUPPORTER 审中-公开

    公开(公告)号：US20170135842A1

    公开(公告)日：2017-05-18

    申请号：US15322927

    申请日：2015-07-01

    Applicant: KOWA COMPANY, LTD. ,  ADVANCING INC. ,  DMCHAIN COOPERATIVE

    Inventor： Akiharu TSUCHIYA ,  Hitoshi OJIMA ,  Hidenori KASENO

    IPC: A61F5/02

    CPC classification number: A61F5/028 ,  A61F5/02

    Abstract: Provided is a supporter in which it is possible to prevent floating of the supporter from the back portion of a wearer of the supporter in an upper side and a lower side of a back-contact section having a wide width and reliably support the waist portion of the wearer. The supporter 100 comprises: a band-shaped body section 10 provided with a back-contact section 11 which is brought into contact with the back portion of a wearer, and protruding sections 12 protruding to the right and left from both sides of the back-contact section 11; a pair of right and left auxiliary band sections 31 and 32 fixed so as to intersect one another in the vicinity of an upper side 11a of the back-contact section 11; a pair of right and left adjustment band sections 51 and 52 loosely inserted into annular rings 41 and 42 respectively disposed at the auxiliary band sections 31 and 32; and a band-shaped support band section 70 fixed to the vicinity of a lower side 11b of the back-contact section 11.

    INTRAOCULAR LENS INSERTION APPARATUS
    100.
    发明申请
    INTRAOCULAR LENS INSERTION APPARATUS 审中-公开
    内窥镜镜片插入装置

    公开(公告)号：US20160278914A1

    公开(公告)日：2016-09-29

    申请号：US15037469

    申请日：2014-11-19

    Applicant: KOWA COMPANY, LTD.

    Inventor： Takashi Sato

    IPC: A61F2/16

    CPC classification number: A61F2/1675 ,  A61F2/1678

    Abstract: An intraocular lens insertion apparatus includes an accommodating member integrally or independently formed on an apparatus body which is inserted into an eyeball, allowing arrangement of the intraocular lens in the apparatus body by accommodating the intraocular lens therein, and having a hole through which a needle of a syringe which supplies a lubricant to the intraocular lens passes. Further, the intraocular lens insertion apparatus includes a guide wall member formed on the accommodating member at a position adjacent to the hole, and being configured to guide the needle of the syringe to the hole.

    Abstract translation: 眼内透镜插入装置包括一体地或独立地形成在插入眼球的装置主体上的容纳构件，允许通过在其中容纳眼内透镜来将眼内透镜布置在装置主体中，并且具有孔， 向眼内透镜供给润滑剂的注射器通过。 此外，眼内透镜插入装置包括在邻近孔的位置处形成在容纳构件上的引导壁构件，并且构造成将注射器的针引导到孔。

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