专利检索 ap:"Nicholas A. Meanwell" 第 10 页

91.

发明申请
C-28 AMINES OF C-3 MODIFIED BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS 有权
标题翻译：作为HIV成熟抑制剂的C-28修饰的乳清酸衍生物的C-28氨基酸

公开(公告)号：US20130029954A1

公开(公告)日：2013-01-31

申请号：US13359680

申请日：2012-01-27

申请人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu

发明人： Alicia Regueiro-Ren , Jacob Swidorski , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell , Zheng Liu

IPC分类号： A61K31/565 , A61P31/18 , A61P31/14 , C07J53/00 , A61K31/58

CPC分类号： C07J63/008

摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula I a compound of formula II and a compound of formula III

摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，具有独特抗病毒活性的C-3修饰的桦木酸衍生物的C-28胺被提供为HIV成熟抑制剂。这些化合物可用于治疗艾滋病毒和艾滋病。特别地，本文提供以下化合物，包括其药学上可接受的盐：式I化合物式II化合物和式III化合物

92.

发明申请
Hepatitis C Virus Inhibitors 有权

公开(公告)号：US20130004457A1

公开(公告)日：2013-01-03

申请号：US13609957

申请日：2012-09-11

申请人： Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann

发明人： Carol Bachand , Makonen Bekema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann

IPC分类号： C07D403/14 , A61K31/506 , C07D417/14 , A61K31/427 , C07D405/14 , A61P31/16 , A61K31/4545 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/7105 , A61K31/4745 , A61K31/4178 , C07D401/14

CPC分类号： A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

93.

发明申请
Hepatitis C Virus Inhibitors 有权

公开(公告)号：US20120328570A1

公开(公告)日：2012-12-27

申请号：US13606231

申请日：2012-09-07

申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann

发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann

IPC分类号： A61K31/4178 , C07D401/14 , A61K31/4545 , C07D413/14 , A61K31/5377 , A61P31/14 , A61K31/695 , A61K38/21 , A61K31/7056 , A61K38/20 , A61K31/713 , C07D403/14 , C07F7/10

CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

94.

发明申请
PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开
标题翻译：替代酰基氨基哌啶衍生物与蛋白酶抑制剂的药物制剂

公开(公告)号：US20120238583A1

公开(公告)日：2012-09-20

申请号：US13473683

申请日：2012-05-17

申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

IPC分类号： A61K31/496 , A61P31/18

CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048

摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。

95.

发明申请
HIV Integrase Inhibitors 有权
标题翻译： HIV整合酶抑制剂

公开(公告)号：US20110245241A1

公开(公告)日：2011-10-06

申请号：US12901147

申请日：2010-10-08

申请人： B. Narasimhulu Naidu , Kevin Peese , Ira B. Dicker , Chen Li , Manoj Patel , Nicholas A. Meanwell , Michael A. Walker

发明人： B. Narasimhulu Naidu , Kevin Peese , Ira B. Dicker , Chen Li , Manoj Patel , Nicholas A. Meanwell , Michael A. Walker

IPC分类号： A61K31/5383 , C07D498/04 , C07D413/04 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P31/18

CPC分类号： C07D498/04 , C07D413/04

摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。本发明还包括用于治疗感染HIV的那些的药物组合物和方法。

96.

发明授权
Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂

公开(公告)号：US08003604B2

公开(公告)日：2011-08-23

申请号：US11939753

申请日：2007-11-14

申请人： Alan Xiangdong Wang , Barbara Zhizhen Zheng , Stanley D'Andrea , Nicholas A. Meanwell , Paul Michael Scola

发明人： Alan Xiangdong Wang , Barbara Zhizhen Zheng , Stanley D'Andrea , Nicholas A. Meanwell , Paul Michael Scola

IPC分类号： A61K38/00

CPC分类号： C07D498/04 , C07D487/04 , C07K5/0802 , C07K5/0815

摘要： Macrocyclic peptides having the general formula: are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

摘要翻译： 公开了具有以下通式的大环肽。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

97.

发明授权
Diketo substituted pyrrolo[2,3-c] pyridines 有权
标题翻译：二酮取代的吡咯并[2,3-c]吡啶

公开(公告)号：US07960406B2

公开(公告)日：2011-06-14

申请号：US12490714

申请日：2009-06-24

申请人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Barry L. Johnson , Nicholas A. Meanwell , John F. Kadow

发明人： Tao Wang , Yasutsugu Ueda , Lawrence G. Hamann , Zhongxing Zhang , Zhiwei Yin , Alicia Regueiro-Ren , David J. Carini , Jacob Swidorski , Zheng Liu , Barry L. Johnson , Nicholas A. Meanwell , John F. Kadow

IPC分类号： A61K31/44

CPC分类号： C07D487/04 , C07D471/04 , C07D519/00

摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.

摘要翻译： 阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，提供具有独特抗病毒活性的二酮稠合偶氮哌啶和式I的偶氮哌嗪衍生物。这些化合物可用于治疗艾滋病毒和艾滋病。

98.

发明申请
PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开

公开(公告)号：US20110118279A1

公开(公告)日：2011-05-19

申请号：US13007194

申请日：2011-01-14

申请人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

发明人： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

IPC分类号： A61K31/496 , A61P31/18

CPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048

摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.