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公开(公告)号：US08846659B2
公开(公告)日：2014-09-30
申请号：US13313423
申请日：2011-12-07
申请人： Kevin Peese , B. Narasimhulu Naidu , Manoj Patel , Chen Li , Michael A. Walker
发明人： Kevin Peese , B. Narasimhulu Naidu , Manoj Patel , Chen Li , Michael A. Walker
IPC分类号： A61K31/55 , C07D487/08 , C07D487/04
CPC分类号： C07D487/04
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
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2.发明授权Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译： 本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。
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3.发明授权Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase 有权用于通过抑制极光激酶治疗癌症的吡咯嗪衍生物公开(公告)号：US08338594B2
公开(公告)日：2012-12-25
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20120309698A1
公开(公告)日：2012-12-06
申请号：US13312483
申请日：2011-12-06
申请人： Yasutsugu Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
发明人： Yasutsugu Ueda , Timothy P. Connolly , Barry L. Johnson , Chen Li , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Margaret E. Sorenson , Michael A. Walker , Michael S. Bowsher , Rongti Li
IPC分类号： A61K31/55 , A61K31/655 , A61K31/553 , A61P31/18 , A61K31/7028 , C07J43/00 , A61K31/58 , C07D487/08 , C07H15/26
CPC分类号： C07D487/08 , C07D519/00
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
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5.发明申请USE OF MANGANESE PEROXIDASE FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL 有权锰酸过氧化物用于致密性水解物质的应用公开(公告)号：US20120149065A1
公开(公告)日：2012-06-14
申请号：US13297111
申请日：2011-11-15
申请人： Chris DaCunha , Adrian Galvez , Michael Guerini , Manoj Patel , Ngim Ung-Ferrell , Jennifer Headman
发明人： Chris DaCunha , Adrian Galvez , Michael Guerini , Manoj Patel , Ngim Ung-Ferrell , Jennifer Headman
CPC分类号： C12N9/0065 , C12N15/81 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y111/01013 , Y02E50/16 , Y02E50/17
摘要： Improved manganese peroxidases, polynucleotides encoding improved manganese peroxidase and vectors and cells thereof are provided, as well as methods for converting a cellulose-containing biomass feedstock to ethanol using improved manganese peroxidases and cells expressing a heterologous manganese peroxidase as disclosed herein.
摘要翻译： 提供了改进的锰过氧化物酶，编码改进的锰过氧化物酶的多核苷酸和载体及其细胞，以及使用改进的锰过氧化物酶和表达本文公开的异源锰过氧化物酶的细胞将含纤维素的生物质原料转化为乙醇的方法。
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公开(公告)号：US07678804B2
公开(公告)日：2010-03-16
申请号：US11078681
申请日：2005-03-10
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y表示芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20090253677A1
公开(公告)日：2009-10-08
申请号：US12406268
申请日：2009-03-18
申请人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson
发明人： Francis Beaulieu , Carl Ouellet , B. Narasimhulu Naidu , Manoj Patel , Yasutsugu Ueda , Timothy P. Connolly , Jonathan R. Weiss , Michael A. Walker , Nicholas A. Meanwell , Kevin M. Peese , Margaret E. Sorenson
IPC分类号： A61K31/551 , A61K31/55 , A61K31/537 , A61K31/529 , C07D487/14 , C07D487/04 , C07D498/18 , C07D471/04
CPC分类号： C07D498/18 , C07D471/08 , C07D471/18 , C07D487/08 , C07D493/18
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US08383639B2
公开(公告)日：2013-02-26
申请号：US12901147
申请日：2010-10-08
申请人： B. Narasimhulu Naidu , Kevin Peese , Ira B. Dicker , Chen Li , Manoj Patel , Nicholas A. Meanwell , Michael A. Walker
发明人： B. Narasimhulu Naidu , Kevin Peese , Ira B. Dicker , Chen Li , Manoj Patel , Nicholas A. Meanwell , Michael A. Walker
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D498/04 , C07D413/04
摘要： The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译： 本公开一般涉及式I的新化合物，包括其盐，其抑制HIV整合酶并防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。
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公开(公告)号：US20090149876A1
公开(公告)日：2009-06-11
申请号：US12330508
申请日：2008-12-08
申请人： Manoj Patel , David Hoenig
发明人： Manoj Patel , David Hoenig
CPC分类号： A61B17/32056 , A61B17/12009 , A61B17/12013 , A61B2017/00004 , A61B2017/00407 , A61B2017/0496 , A61B2017/12004 , A61B2017/12018
摘要： A surgical clamp is provided that is applied through a laparoscopic port and is used for clamping off a portion of an organ. The surgical clamp comprises an elongated flexible bioabsorbable polymer band. The band has a proximal end and a distal end. A bioabsorbable polymer tie secures in place the proximal end of the band to the distal end of the band.
摘要翻译： 提供外科夹具，其通过腹腔镜端口施加并用于夹紧器官的一部分。 手术夹具包括细长的柔性生物可吸收聚合物带。 带具有近端和远端。 生物可吸收的聚合物束带将带的近端固定到带的远端。
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公开(公告)号：US20050277640A1
公开(公告)日：2005-12-15
申请号：US11078681
申请日：2005-03-10
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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