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公开(公告)号:US08394968B2
公开(公告)日:2013-03-12
申请号:US12846152
申请日:2010-07-29
申请人: Jeffrey Lee Romine
发明人: Jeffrey Lee Romine
IPC分类号: A61K31/4184 , C07D235/02
CPC分类号: C07D403/14 , C07D405/14 , C07D413/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20110077280A1
公开(公告)日:2011-03-31
申请号:US12729940
申请日:2010-03-23
申请人: John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
发明人: John A. Bender , Piyasena Hewawasam , John F. Kadow , Omar D. Lopez , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Lawrence B. Snyder , Denis R. St. Laurent , Gan Wang , Ningning Xu , Makonen Belema
IPC分类号: A61K31/4178 , C07D403/14 , A61K31/4184 , C07D405/14 , A61P31/14
CPC分类号: C07D403/04 , C07D403/14 , C07D405/14
摘要: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
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公开(公告)号:US20080299075A1
公开(公告)日:2008-12-04
申请号:US12029680
申请日:2008-02-12
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61K31/7088 , A61K38/16 , A61P31/12
CPC分类号: C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本公开涉及用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US20080044379A1
公开(公告)日:2008-02-21
申请号:US11835485
申请日:2007-08-08
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号: A61K38/20 , A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , A61K38/21 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02 , C07D237/02 , C07D233/54 , C07D221/00 , A61P31/12 , A61K31/4523 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/7052
CPC分类号: C07D401/14 , C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US08809548B2
公开(公告)日:2014-08-19
申请号:US12701919
申请日:2010-02-08
申请人: Jeffrey Lee Romine , Denis R. St. Laurent , Makonen Belema , Lawrence B. Snyder , Lawrence G. Hamann , John F. Kadow , Jayne Kapur , Andrew C. Good , Omar D. Lopez , Rico Lavoie , John A. Bender
发明人: Jeffrey Lee Romine , Denis R. St. Laurent , Makonen Belema , Lawrence B. Snyder , Lawrence G. Hamann , John F. Kadow , Jayne Kapur , Andrew C. Good , Omar D. Lopez , Rico Lavoie , John A. Bender
IPC分类号: A61K31/422 , A61K31/4184 , C07D403/14 , C07D413/14
CPC分类号: C07D403/14 , A61K31/4184 , A61K31/422 , A61K31/454 , A61K31/4725 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D405/14 , C07D413/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US08574563B2
公开(公告)日:2013-11-05
申请号:US13609957
申请日:2012-09-11
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , C07D417/14 , C07D405/14 , C07D401/14 , A61K31/506 , A61K31/427 , A61K38/21 , A61K31/7056 , A61K31/7105 , A61K31/4745 , A61K38/20 , A61P31/16
CPC分类号: A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US08303944B2
公开(公告)日:2012-11-06
申请号:US12030232
申请日:2008-02-13
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D403/14 , A61K31/4178 , A61K31/506 , A61K31/16 , A61K31/7088 , A61K38/20 , A61K38/21 , A61K38/43 , A61K38/48 , A61P31/12
CPC分类号: A61K31/506 , A61K31/13 , A61K31/4178 , A61K31/427 , A61K31/4745 , A61K31/7056 , A61K31/7105 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US08147818B2
公开(公告)日:2012-04-03
申请号:US12358587
申请日:2009-01-23
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: A61K38/20 , A61K31/4184 , A61K31/55 , A61K38/05 , A61K38/21 , A61K31/708 , C07D403/14 , C07D487/04
CPC分类号: C07D403/14 , C07D405/14 , C07D487/04 , C07D491/044 , C07D491/052
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US20110286961A1
公开(公告)日:2011-11-24
申请号:US12957512
申请日:2010-12-01
申请人: Makonen Belema , Jeffrey Lee Romine , Van N. Nguyen , Gan Wang , Omar D. Lopez , Denis R. St. Laurent , Qi Chen , John A. Bender , Zhong Yang , Piyasena Hewawasam , Ningning Xu , Nicholas A. Meanwell , John A. Easter , Bao-Ning Su , Michael J. Smith
发明人: Makonen Belema , Jeffrey Lee Romine , Van N. Nguyen , Gan Wang , Omar D. Lopez , Denis R. St. Laurent , Qi Chen , John A. Bender , Zhong Yang , Piyasena Hewawasam , Ningning Xu , Nicholas A. Meanwell , John A. Easter , Bao-Ning Su , Michael J. Smith
IPC分类号: A61K31/4178 , C07D405/14 , A61K38/21 , A61P31/14 , A61K38/20 , A61K31/7088 , A61K31/4745 , C07D403/14 , A61K31/7056
CPC分类号: C07D403/14 , C07D405/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号:US07745636B2
公开(公告)日:2010-06-29
申请号:US12029680
申请日:2008-02-12
申请人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
发明人: Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Gan Wang , Lawrence G. Hamann
IPC分类号: C07D233/02 , A01N43/50
CPC分类号: C07D403/14
摘要: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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