公开(公告)号：US11466010B2

公开(公告)日：2022-10-11

申请号：US16760815

申请日：2018-10-30

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Hang Hubert Yin ,  Shuting Zhang ,  Zhenyi Hu

IPC: C07D487/04 ,  C07D215/18 ,  C07D215/20 ,  C07D401/04

Abstract: Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

公开(公告)号：US20220313785A1

公开(公告)日：2022-10-06

申请号：US17845101

申请日：2022-06-21

Applicant: Xalud Therapeutics, Inc. ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Raymond A. Chavez ,  Linda May Rothblum Watkins ,  Robert Landry

IPC: A61K38/20 ,  A61K48/00 ,  C07K14/54

Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.

公开(公告)号：US11433088B2

公开(公告)日：2022-09-06

申请号：US16426680

申请日：2019-05-30

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： Douglas R. Seals ,  Lindsey Gano ,  Natalie Poliektor

IPC: A61K31/706

Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.

公开(公告)号：US20220265472A1

公开(公告)日：2022-08-25

申请号：US17741170

申请日：2022-05-10

Applicant: The Regents of the University of Colorado, a body corporate ,  New World Medical, Inc.

Inventor： Malik Y. KAHOOK ,  Khalid MANSOUR ,  Suhail ABDULLAH ,  Eric PORTEOUS ,  Vijay R. BALAN

IPC: A61F9/013 ,  A61F9/007 ,  A61B17/32

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

公开(公告)号：US20220259490A1

公开(公告)日：2022-08-18

申请号：US17615139

申请日：2020-06-10

Applicant: Alliance for Sustainable Energy, LLC ,  The Regents of the University of Colorado, a Body Corporate

Inventor： Matthew Craig BEARD ,  Marissa Sally MARTINEZ ,  Zhiyuan HUANG

IPC: C09K11/02 ,  C07C57/60 ,  C09K11/66

Abstract: The present disclosure relates to a nanocrystal that includes a nanocrystal core, a first ligand coordinated to a first portion of a surface of the nanocrystal core, and a second ligand coordinated to a second portion of the surface, where the second ligand includes a first functionalized aromatic molecule.

公开(公告)号：US20220251827A1

公开(公告)日：2022-08-11

申请号：US17631089

申请日：2020-07-29

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Moncef Krarti

IPC: E04B1/76

Abstract: This disclosure describes systems, methods, and apparatus for a structural insulation assembly having a variable insulating value and being incorporated into a thermal envelope of a structure, the assembly comprising a first and second surface; a cavity between the first and second surfaces and at least partially filled with a gas; a plurality of insulating elongated fins fixed to distinct rotational axes parallel to each other, the plurality of elongated fins being continuously rotatable between a closed position, where the plurality of elongated fins are substantially vertical, and a fully open position, where the plurality of elongated fins are perpendicular to the first and second surfaces and parallel to each other; an actuator for controlling a rotational angle of the insulating elongated fins to effectuate the variable insulating value; and a controller configured to pass instructions to the actuator dictating the angle of the insulating elongated fins.

公开(公告)号：US20220240762A1

公开(公告)日：2022-08-04

申请号：US17721157

申请日：2022-04-14

Applicant: The Regents of the University of Colorado, a Body Corporate ,  Aspero Medical, Inc.

Inventor： Mark E. Rentschler ,  Allison B. Lyle ,  Jeffrey P. Castleberry

IPC: A61B1/00

Abstract: An overtube assembly for use with an elongate medical includes a flexible tubular body having a proximal end and a distal end, the flexible tubular body including a tube split extending longitudinally from the proximal end to the distal end. The flexible tubular body defines each of a primary lumen extending from the proximal end to the distal end and accessible through the tube split and a secondary lumen separate from the primary lumen.

公开(公告)号：US20220221354A1

公开(公告)日：2022-07-14

申请号：US17574880

申请日：2022-01-13

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jianliang Xiao ,  Wei Zhang ,  Chuanqian Shi

IPC: G01L1/22 ,  A61B5/00 ,  G01L1/20

Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.

公开(公告)号：US20220216812A1

公开(公告)日：2022-07-07

申请号：US17570059

申请日：2022-01-06

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Garret Moddel

IPC: H02N11/00 ,  H01L35/28

Abstract: Described herein are devices incorporating Casimir cavities, which modify the quantum vacuum mode distribution within the cavities. The Casimir cavities can create energy differences within layers or device to drive energy from or to a portion of a layer disposed adjacent to or contiguous with the Casimir cavity by modifying the quantum vacuum mode distribution incident on one portion of the layer to be different from the quantum vacuum mode distribution incident on another portion of the layer. Additionally, Casimir cavities in which the cavity layer comprises a conductor that can be used to carry a flow of electrical power induced by the presence of the Casimir cavity.

公开(公告)号：US20220186120A1

公开(公告)日：2022-06-16

申请号：US17548388

申请日：2021-12-10

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Haridas Mundoor ,  Ivan I. Smalyukh

IPC: C09K19/52

Abstract: Composite condensed matter material, devices including the composite condensed matter material, and methods of forming and using the composite condensed matter material are disclosed. The composite condensed matter material includes a host material and particles dispersed and suspended within the host material. The composite condensed matter material can exhibit one or more low symmetry phases and reconfigurable properties.