公开(公告)号：US20050187282A1

公开(公告)日：2005-08-25

申请号：US11117459

申请日：2005-04-29

申请人： Jonathan Roffey ,  James Davidson ,  Howard Mansell ,  Richard Hamlyn ,  David Adams

发明人： Jonathan Roffey ,  James Davidson ,  Howard Mansell ,  Richard Hamlyn ,  David Adams

IPC分类号： C07D491/048 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4745 ,  A61P1/04 ,  A61P3/04 ,  A61P7/02 ,  A61P9/10 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D209/60 ,  C07D209/70 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  A61K31/403 ,  C07D209/56

CPC分类号： C07D471/04 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4745 ,  C07D209/60 ,  C07D209/70 ,  C07D209/90 ,  C07D471/06 ,  C07D491/04 ,  C07D491/06 ,  C07D495/04 ,  C07D495/06

摘要： A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

摘要翻译： 式（I）的化合物，其中R 1和R 2各自独立地选自氢和烷基; R 3是烷基; R 4和R 5选自氢和烷基; R 6和R 7独立地选自氢，卤素，羟基，烷基，芳基，氨基，烷基氨基，二烷基氨基，烷氧基，芳氧基，烷硫基，烷基亚砜基，硝基，腈 ，碳 - 烷氧基，碳 - 芳氧基和羧基; 并且A是任选地含有一个或多个杂原子的5-或6-元环，其中除了环A稠合的苯环的不饱和碳原子之外的环A的原子是饱和或不饱和的， 可接受的盐，加成化合物和前药; 以及其在治疗中的用途，特别是作为5HT受体，特别是5HT 2C受体的激动剂或拮抗剂，例如用于治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 尿崩症和睡眠呼吸暂停，特别是用于治疗肥胖。

公开(公告)号：US20050125209A1

公开(公告)日：2005-06-09

申请号：US10728295

申请日：2003-12-04

申请人： Mohamed Soliman ,  Loyd East ,  David Adams

发明人： Mohamed Soliman ,  Loyd East ,  David Adams

IPC分类号： E21B41/00 ,  E21B43/26 ,  E21B49/00 ,  G06G7/48

CPC分类号： E21B49/006 ,  E21B43/26 ,  G01V99/005 ,  G01V2210/646

摘要： The present invention relates generally to methods for designing and optimizing the number, placement, and size of fractures in a subterranean formation and more particularly to methods that account for stress interference from other fractures when designing and optimizing the number, placement, and size of fractures in the subterranean formation. The present invention optimizes the number, placement and size of fractures in a subterranean formation. The present invention determinines one or more geomechanical stresses induced by each fracture based on the dimensions and location of each fracture. The present invention determinines a maximum number of fractures and a predicted stress field based on the geomechanical stresses induced by each of the fractures

摘要翻译： 本发明一般涉及用于设计和优化地层中裂缝的数量，位置和尺寸的方法，更具体地涉及在设计和优化裂缝的数量，位置和尺寸时考虑来自其他裂缝的应力干扰的方法 在地层中。 本发明优化了地层中裂缝的数量，位置和尺寸。 本发明基于每个断裂的尺寸和位置确定由每个断裂引起的一个或多个地质力学应力。 本发明基于每个断裂引起的地质力学应力来确定最大数量的裂缝和预测的应力场

公开(公告)号：US20050046234A1

公开(公告)日：2005-03-03

申请号：US10653290

申请日：2003-09-03

申请人： Linton Myers ,  David Adams ,  Roland Moriaux ,  Bernard Nigay

发明人： Linton Myers ,  David Adams ,  Roland Moriaux ,  Bernard Nigay

IPC分类号： B62D33/06

CPC分类号： B62D33/0612 ,  B62D33/06 ,  Y10T29/49876 ,  Y10T29/49904 ,  Y10T29/5147

摘要： A modular cab/sleeper/roof structural assembly for a truck-tractor vehicle according to the present invention provides greater manufacturing flexibility and unrestricted access between a cab/sleeper unit. The structural assembly includes a top-free cab unit having a front wall, opposing side walls, and a bottom portion. A top-free sleeper unit positioned behind the cab unit has a rear wall, opposing side walls, and a bottom portion. Fasteners couple the cab unit and the sleeper unit such that an upwardly opened carriage assembly is formed. A unitary roof member fixedly encloses the opened carriage assembly and forms an integral modular unit. The unitary roof member has a front portion connected to the front wall of the cab unit, a rear portion connected to the rear wall of the sleeper unit, and opposing side portions connected to the opposing side walls of the cab and sleeper units. The cab unit, sleeper unit and roof member are not independent structures; however, when they are assembled, the units constitute a durable cab/sleeper unit.

公开(公告)号：US06426723B1

公开(公告)日：2002-07-30

申请号：US09765532

申请日：2001-01-19

申请人： Martin Smith ,  Sonya Amos ,  Dean Kitchener ,  Dawn Power ,  David Adams

发明人： Martin Smith ,  Sonya Amos ,  Dean Kitchener ,  Dawn Power ,  David Adams

IPC分类号： H01Q138

CPC分类号： H01Q1/22 ,  H01Q1/2258 ,  H01Q1/2266 ,  H01Q1/24 ,  H01Q9/04 ,  H01Q9/0421 ,  H01Q9/42 ,  H01Q21/24 ,  H01Q21/28 ,  H01Q21/29 ,  H04B7/10

摘要： The present invention relates to antennas for radio communications, and in particular although not exclusively to multiple input multiple output (MIMO) radio communications systems. An antenna arrangement comprising: a first, a second, and a third ground plane each arranged substantially perpendicular to the others; a first, a second, and a third antenna element associated with respectively said first, said second, and said third ground planes, each antenna element arranged to radiate in a predetermined polarization in elevation and azimuth with respect to said respective associated ground plane.

摘要翻译： 本发明涉及用于无线电通信的天线，特别是尽管不是排他地涉及多输入多输出（MIMO）无线电通信系统。 一种天线装置，包括：第一，第二和第三接地平面，每个接地平面大致垂直于其他接地平面; 分别与所述第一，所述第二和所述第三接地平面相关联的第一，第二和第三天线元件，每个天线元件布置成相对于所述相应的相关联的接地平面在高程和方位角以预定极化辐射。

公开(公告)号：US4026199A

公开(公告)日：1977-05-31

申请号：US620006

申请日：1975-10-06

申请人： David Adams ,  Ralmond J. Smiltneck

发明人： David Adams ,  Ralmond J. Smiltneck

IPC分类号： B26D1/08 ,  B26D7/18 ,  B31B50/20 ,  B31B1/20

CPC分类号： B26D7/1818 ,  B26D1/085 ,  B31B1/00 ,  B31B2201/147 ,  Y10T83/2079 ,  Y10T83/2194

摘要： Sheets of paperboard or the like are gripped along one end by a plurality of grippers and are drawn by the grippers along a predetermined path for processing. An array of stripper tools mounted at the end of the path strips the body of the sheet free from a waste strip which remains gripped by the grippers. The waste strip is carried away from the stripper tools by the grippers and is subsequently released at another station. The stripper blades are driven by a reciprocating drive mechanism which includes a reciprocating slide, a spring urging the slide in one direction, a rotating arcuate cam flange which periodically blocks movement of the slide and periodically frees it for movement, and another rotating cam which reciprocates the slide through one cycle each time it is free to move.

摘要翻译： 纸板等的一端通过多个夹持器夹持，并且由夹持器沿着预定的路径被拉出以进行处理。 安装在路径端部的剥离器工具的阵列剥离片材的主体，而不会被夹持器夹持的废物条带。 废料带通过夹具从剥离器工具中移走，随后在另一个工位上释放。 剥离器叶片由往复式驱动机构驱动，该往复驱动机构包括往复运动的滑动件，沿一个方向推动滑动件的弹簧，周期性地阻挡滑块运动并周期性地使其移动的旋转弓形凸轮凸缘，以及另一个往复运动的旋转凸轮 每次都可以自由移动一个循环。