公开(公告)号：US11193115B2

公开(公告)日：2021-12-07

申请号：US17200110

申请日：2021-03-12

Applicant: Inscripta, Inc.

Inventor： Benjamin Mijts ,  Juhan Kim ,  Aamir Mir ,  Andrew Garst ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/113

Abstract: The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.

公开(公告)号：US20210355467A1

公开(公告)日：2021-11-18

申请号：US17388358

申请日：2021-07-29

Applicant: Inscripta, Inc.

Inventor： Aamir Mir ,  Andrew Garst ,  Stephen Federowicz ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/62 ,  C12N15/11 ,  C12N15/70

Abstract: The present disclosure relates to methods and compositions that allow one to identify in vivo edited cells when employing nucleic-acid guided editing. Additionally provided are automated multi-module instruments for performing editing and selection methods and using the compositions.

公开(公告)号：US20210324355A1

公开(公告)日：2021-10-21

申请号：US17200110

申请日：2021-03-12

Applicant: Inscripta, Inc.

Inventor： Benjamin Mijts ,  Juhan Kim ,  Aamir Mir ,  Andrew Garst ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/113

Abstract: The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.

公开(公告)号：US20210301270A1

公开(公告)日：2021-09-30

申请号：US17200089

申请日：2021-03-12

Applicant: Inscripta, Inc.

Inventor： Benjamin Mijts ,  Juhan Kim ,  Aamir Mir ,  Andrew Garst ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/113

Abstract: The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.

公开(公告)号：US20210214672A1

公开(公告)日：2021-07-15

申请号：US17140059

申请日：2021-01-02

Applicant: Inscripta, Inc.

Inventor： Aamir Mir ,  Erik Zimmerman ,  Emily Feldman ,  Benjamin Mijts ,  Andrew Garst

IPC: C12M1/36 ,  C12N15/10

Abstract: The present disclosure provides compositions, automated multi-module instruments and methods to increase the percentage of edited mammalian cells in a cell population when employing nucleic-acid guided editing.

公开(公告)号：US20210171923A1

公开(公告)日：2021-06-10

申请号：US17084522

申请日：2020-10-29

Applicant: Inscripta, Inc.

Inventor： Benjamin Mijts ,  Juhan Kim ,  Aamir Mir ,  Andrew Garst ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/113

Abstract: The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.

公开(公告)号：US20210095241A1

公开(公告)日：2021-04-01

申请号：US17101897

申请日：2020-11-23

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Andrew Garst ,  Richard Fox

IPC: C12M1/00 ,  C12M1/26 ,  C12N15/87 ,  C12M3/00

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US10883095B1

公开(公告)日：2021-01-05

申请号：US16837212

申请日：2020-04-01

Applicant: Inscripta, Inc.

Inventor： Benjamin Mijts ,  Juhan Kim ,  Aamir Mir ,  Andrew Garst ,  Kyle Seamon

IPC: C12N9/22 ,  C12N15/113

Abstract: The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.

公开(公告)号：US10851339B1

公开(公告)日：2020-12-01

申请号：US17013360

申请日：2020-09-04

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Andrew Garst ,  Richard Fox

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/26 ,  C12N15/87 ,  B01D63/08 ,  B01D71/02 ,  B01D69/06

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US10752874B2

公开(公告)日：2020-08-25

申请号：US16686066

申请日：2019-11-15

Applicant: Inscripta, Inc.

Inventor： Charles Johnson ,  Miles Gander ,  Don Masquelier ,  Phillip Belgrader ,  Andrew Garst ,  Matthew Estes ,  Bruce Chabansky ,  Jorge Bernate

IPC: C12M1/00 ,  C12M1/26 ,  C12M3/00 ,  C12N15/87 ,  B01D25/00 ,  B01D63/08 ,  B01D29/05 ,  B01D71/02 ,  B01D69/06

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.