公开(公告)号：US06168778A

公开(公告)日：2001-01-02

申请号：US08870930

申请日：1997-06-06

申请人： Nebojsa Janjic ,  Larry Gold ,  Paul Schmidt ,  Chandra Vargeese

发明人： Nebojsa Janjic ,  Larry Gold ,  Paul Schmidt ,  Chandra Vargeese

IPC分类号： A61K31711

CPC分类号： C12N15/115 ,  A61K38/00 ,  A61K47/544 ,  A61K47/549 ,  C07H19/06 ,  C07H19/10 ,  C07H21/00 ,  C07K14/001 ,  C07K14/47 ,  C07K14/52 ,  C12N9/1276 ,  C12N15/1048 ,  C12N15/88 ,  C12N2310/13 ,  C12N2310/322 ,  C12N2310/3515 ,  C12N2310/53 ,  C12Q1/37 ,  C40B40/00 ,  F02B2075/027 ,  G01N33/531 ,  G01N33/532 ,  G01N33/535 ,  G01N33/56988 ,  G01N33/68 ,  G01N33/76 ,  G01N2333/16 ,  G01N2333/163 ,  G01N2333/503 ,  G01N2333/8125 ,  G01N2333/96433 ,  G01N2333/966 ,  G01N2333/974

摘要： This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.

摘要翻译： 本发明公开了通过SELEX方法鉴定VEGF核酸配体并将VEGF核酸配体与亲脂性化合物缔合而制备由VEGF核酸配体和亲脂性化合物组成的复合物的方法。 本发明进一步公开了包含与亲脂性化合物结合的一种或多种VEGF核酸配体的复合物。 本发明还包括含有VEGF核酸配体或复合物的脂质构建体及其制备方法。

公开(公告)号：US6020206A

公开(公告)日：2000-02-01

申请号：US99588

申请日：1998-06-18

申请人： Chandra Vargeese ,  Sumedha Jayasena ,  Nebojsa Janjic

发明人： Chandra Vargeese ,  Sumedha Jayasena ,  Nebojsa Janjic

IPC分类号： G01N33/68

CPC分类号： G01N33/68 ,  G01N33/6815

摘要： This invention pertains to methods of determining the presence and/or quantity of homocysteine in a sample containing other thiol-containing compounds. The methods of this invention involve modifying the homocysteine to facilitate the separation of homocysteine from cysteine. An assay protocol comprises adjusting the conditions of the sample suspected of containing homocysteine so that homocysteine forms homocysteine thiolactone, separating the homocysteine thiolactone from free thiol-containing compounds present in the sample, including cysteine, reconverting the homocysteine thiolactone to homocysteine, and determining the presence and/or quantity of homocysteine in the sample by conventional means.

摘要翻译： 本发明涉及确定含有其它含硫醇化合物的样品中同型半胱氨酸的存在和/或量的方法。 本发明的方法涉及修饰同型半胱氨酸以促进半胱氨酸与半胱氨酸的分离。 测定方案包括调整怀疑含有同型半胱氨酸的样品的条件，使得同型半胱氨酸形成同型半胱氨酸硫内酯，将同型半胱氨酸硫内酯与存在于样品中的游离含硫醇化合物（包括半胱氨酸）分离，将同型半胱氨酸硫内酯重新转化为同型半胱氨酸， 和/或样品中同型半胱氨酸的量。