摘要:
A flow noise restrictor for use with a valve. The flow noise restrictor reduces the flow area as the valve closes and forms vortices to reduce the noise such as due to the Bernoulli effect.
摘要:
A multi flush volume flush valve is in communication with an automatic flush control. The flush control determines the presence of a user and the amount of time the user uses the toilet. The usage time is compared to a predetermined time value to determine the appropriate flush volume based on an assumption regarding usage time and flush volume needs. The comparative value statistically adjusts to the restroom traffic.
摘要:
An embodiment of the invention provides a method of promoting regression of cancer in a mammal comprising obtaining a tumor tissue sample from the mammal; culturing the tumor tissue sample in a first gas permeable container containing cell medium therein; obtaining tumor infiltrating lymphocytes (TIL) from the tumor tissue sample; expanding the number of TIL in a second gas permeable container containing cell medium therein using irradiated allogeneic feeder cells and/or irradiated autologous feeder cells; and administering the expanded number of TIL to the mammal. Methods of obtaining an expanded number of TIL from a mammal for adoptive cell immunotherapy are also provided.
摘要:
Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.
摘要:
The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
摘要:
A flush valve diaphragm is provided. The diaphragm includes at least two by-passes orifices. Each by-pass orifice in the diaphragm has a by-pass associated therewith. Each by-pass having a passage therethrough, allows communication with the control chamber above the diaphragm with an inlet chamber below the diaphragm. The diaphragm also integrates the function of locating and providing sealing means to the flush valve system's aux valve mechanism.
摘要:
An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
摘要翻译:培养用于细胞治疗应用的细胞的改进方法,其包括在存在抗原呈递细胞和/或饲养细胞的情况下生长期望的细胞,并且如果不包括生长表面,则中等体积与表面积比高达1ml / cm 2 的气体可渗透材料,如果生长表面由透气材料组成,则高达2ml / cm2。 期望的细胞在生产周期开始时的表面密度小于0.5×10 6个细胞/ cm 2,并且所需细胞的表面密度加上抗原呈递细胞和/或饲养细胞的表面密度至少为 约1.25×10 5个细胞/ cm 2。
摘要:
An apparatus for shipping, storing, and viewing a cornea. The device offers an improvement to cornea health relative to conventional cornea containers.
摘要:
A flush mechanism for use in a urinal. The flush mechanism includes a flush reservoir pivotally mounted within a flush frame. The flush mechanism receives water from an inlet above the flush reservoir. The flush reservoir is pivotable from a fill position to a flush position whereby the water is dispensed to a manifold within the urinal for flushing of the urinal. The flow of water into the flush reservoir and the actuation of the flush reservoir may be directed by a controller.
摘要:
A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.