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281 条记录 (耗时 0.091 秒)

    RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
    97.
    发明授权
    RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) 有权
    使用短干扰核酸（siNA）的RNA干扰介导的Fos基因表达的抑制

    公开(公告)号：US07910724B2

    公开(公告)日：2011-03-22

    申请号：US12185652

    申请日：2008-08-04

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： This invention relates to compounds, compositions, and methods useful for modulating c-Fos gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of c-Fos gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of c-Fos genes. The small nucleic acid molecules are useful in the treatment of cancer, proliferative diseases or conditions, inflammatory diseases or conditions, allergic diseases or conditions, infectious diseases or conditions, autoimmune diseases or conditions, or transplantation/allograft rejection in a subject or organism.

    摘要翻译： 本发明涉及可用于使用短干扰核酸（siNA）分子调节c-Fos基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与c-Fos基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节c-Fos基因表达的方法。 小核酸分子可用于治疗受试者或生物体中的癌症，增殖性疾病或病症，炎性疾病或病症，过敏性疾病或病症，感染性疾病或病症，自身免疫疾病或病症，或移植/同种异体移植排斥反应。

    RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA)
    98.
    发明授权
    RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) 有权
    RNA干扰介导使用短干扰核酸（siNA）抑制NOGO和NOGO受体基因表达

    公开(公告)号：US07897756B2

    公开(公告)日：2011-03-01

    申请号：US12693900

    申请日：2010-01-26

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/705 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/33 ,  C12N2320/51

    摘要： This invention relates to compounds, compositions, and methods useful for modulating NOGO and/or NOGO receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of NOGO and/or NOGO receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of NOGO and/or NOGO receptor genes, such as NOGO-A, NOGO-B, NOGO-C, NOGO-66 receptor, NI-35, NI-220, NI-250, myelin-associated glycoprotein, tenascin-R, and NG-2.

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节NOGO和/或NOGO受体基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与NOGO和/或NOGO受体基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节NOGO和/或NOGO受体基因如NOGO-A，NOGO-B，NOGO-C，NOGO-66受体，NI-35，NI-220，NI-250，髓磷脂 相关糖蛋白，腱生蛋白-R和NG-2。

    RNA Interference Mediated Inhibition of NOGO and NOGO Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA)
    100.
    发明申请
    RNA Interference Mediated Inhibition of NOGO and NOGO Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权
    RNA干扰介导的使用短干扰核酸（siNA）的NOGO和NOGO受体基因表达的抑制

    公开(公告)号：US20100144842A1

    公开(公告)日：2010-06-10

    申请号：US12693900

    申请日：2010-01-26

    申请人： James McSwiggen ,  Leonid Beigelman

    发明人： James McSwiggen ,  Leonid Beigelman

    IPC分类号： A61K31/7105 ,  C07H21/02 ,  A61P35/00

    CPC分类号： C07K14/705 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/33 ,  C12N2320/51

    摘要： This invention relates to compounds, compositions, and methods useful for modulating NOGO and/or NOGO receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of NOGO and/or NOGO receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of NOGO and/or NOGO receptor genes, such as NOGO-A, NOGO-B, NOGO-C, NOGO-66 receptor, NI-35, NI-220, NI-250, myelin-associated glycoprotein, tenascin-R, and NG-2

    摘要翻译： 本发明涉及使用短干扰核酸（siNA）分子调节NOGO和/或NOGO受体基因表达的化合物，组合物和方法。 本发明还涉及可用于通过使用小核酸分子调节参与NOGO和/或NOGO受体基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的表达和活性的化合物，组合物和方法。 特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） ）分子和用于调节NOGO和/或NOGO受体基因如NOGO-A，NOGO-B，NOGO-C，NOGO-66受体，NI-35，NI-220，NI-250，髓磷脂 相关糖蛋白，腱生蛋白-R和NG-2