-
91.发明申请公开(公告)号：US20130338154A1
公开(公告)日：2013-12-19
申请号：US13503645
申请日：2010-10-22
IPC分类号： C07D401/12 , A61K31/4025 , A61K31/4439 , C07D207/48 , A61K31/40 , C07D417/12 , A61K31/427 , C07D403/12 , A61K31/506 , C07D401/14 , A61K31/4709 , C07D413/14 , A61K31/538 , A61K45/06 , C07D405/12
CPC分类号： A61K45/06 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/538 , C07D207/48 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
摘要： Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
-
92.发明授权公开(公告)号：US08497289B2
公开(公告)日：2013-07-30
申请号：US12648972
申请日：2009-12-29
IPC分类号： A61K31/44 , C07D403/02
CPC分类号： C07D209/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12
摘要： In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作1型甘氨酸转运蛋白（GlyT1）活性抑制剂的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与甘氨酸1型转运蛋白（GlyT1）活性相关的病症的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
![Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders](/abs-image/US/2013/04/30/US08431700B2/abs.jpg.150x150.jpg)
93.发明授权Alkylsulfonyl-2,3-dihydrospiro[indene-1,4′-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders 失效作为GlyT1抑制剂的烷基磺酰基-2,3-二氢螺[茚-1,4'-哌啶]类似物，其制备方法及其在治疗精神疾病中的应用公开(公告)号：US08431700B2
公开(公告)日：2013-04-30
申请号：US12716748
申请日：2010-03-03
IPC分类号： C07D401/00
CPC分类号： C07D221/20 , C07D401/12 , C07D409/12
摘要： In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作1型甘氨酸转运蛋白（GlyT1）活性抑制剂的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与甘氨酸1型转运蛋白（GlyT1）活性相关的病症的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
公开(公告)号：US20130065895A1
公开(公告)日：2013-03-14
申请号：US13584735
申请日：2012-08-13
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/437 , A61K31/506 , C07D487/04 , A61K31/519 , A61K31/4985 , A61K31/5377 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/22 , A61P25/00 , A61P3/04 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
-
95.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130040944A1
公开(公告)日：2013-02-14
申请号：US13503644
申请日：2010-10-22
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti
IPC分类号： A61K31/4025 , C07D401/12 , A61K31/4439 , C07D403/12 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/538 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/22 , A61P3/04 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/00 , C07D405/12
CPC分类号： A61K45/06 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/538 , C07D207/48 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
摘要： Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡咯化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
-
96.发明申请BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 有权作为MGLUR5受体的独立型调节剂的双相吡唑化合物公开(公告)号：US20120295913A1
公开(公告)日：2012-11-22
申请号：US13314117
申请日：2011-12-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Carrie K. Jones , Shaun R. Stauffer , José Manuel Bartolome-Nebreda , Gregor James McDonald , Susana Conde-Ceide , Han Min Tong
发明人： P. Jeffrey Conn , Craig W. Lindsley , Carrie K. Jones , Shaun R. Stauffer , José Manuel Bartolome-Nebreda , Gregor James McDonald , Susana Conde-Ceide , Han Min Tong
IPC分类号： A61K31/4985 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/30 , A61P35/00 , A61P25/08 , A61P25/06 , A61P3/10 , A61P3/04 , A61P25/22 , A61P25/24 , C07D487/04 , A61P25/14
CPC分类号： C07D487/04
摘要： In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及双代吡唑化合物，其衍生物和相关化合物，其可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
97.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 失效MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245153A1
公开(公告)日：2012-09-27
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： A61K31/542 , A61K31/4985 , A61K31/506 , A61K31/437 , A61K31/4439 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D401/12 , A61P25/18 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/16 , A61P25/28 , A61K31/5377
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
-
公开(公告)号：US20120172391A1
公开(公告)日：2012-07-05
申请号：US13340641
申请日：2011-12-29
申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James Macdonald , Susana Conde-Ceide , Carrie K. Jones
发明人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James Macdonald , Susana Conde-Ceide , Carrie K. Jones
IPC分类号： A61K31/4375 , A61P25/00 , A61P25/18 , A61P25/14 , A61P25/24 , A61P25/06 , A61P3/10 , A61P3/04 , A61P25/20 , A61P25/22 , C07D471/04 , A61P25/08
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/10 , A61K9/2018 , A61K31/4375
摘要： In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的萘啶酮类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
99.发明申请AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME 审中-公开氨基磷酸酯羧甲基纤维素M1同种异体激动剂，其类似物及其衍生物及其制备方法和使用方法公开(公告)号：US20120088791A1
公开(公告)日：2012-04-12
申请号：US13202272
申请日：2010-02-19
申请人： Craig W. Lindsley , Jeffrey P. Corn , Charles David Weaver , Colleen M. Niswender , Evan P. Lebois , Thomas M. Bridges
发明人： Craig W. Lindsley , Jeffrey P. Corn , Charles David Weaver , Colleen M. Niswender , Evan P. Lebois , Thomas M. Bridges
IPC分类号： A61K31/4545 , C07D409/14 , A61P25/18 , A61P25/16 , A61P25/24 , A61P25/00 , A61P25/28 , A61P25/14 , C07D401/04 , A61P25/22
CPC分类号： C07D401/04 , C07D409/14
摘要： In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M1 muscarinic receptor, synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：可用作M1毒蕈碱受体的变构激动剂的式（I），制备该化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物例如治疗神经变性疾病（包括阿尔茨海默病）的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
100.发明申请BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME 审中-公开BICYCLIC MGLUR5积极的独立调制器及其制造和使用方法公开(公告)号：US20120028955A1
公开(公告)日：2012-02-02
申请号：US13269933
申请日：2011-10-10
申请人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
发明人： P. Jeffrey Conn , Craig W. Lindsley , Charles David Weaver , Alice L. Rodriguez , Colleen M. Niswender , Carrie K. Jones , Richard Williams
IPC分类号： A61K31/472 , C07D413/06 , C07D209/48 , C07D209/46 , C07D401/06 , A61K31/4725 , A61K31/5377 , A61K31/4035 , A61K31/496 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/30 , A61P25/14 , A61P25/08 , A61P25/06 , A61P3/10 , A61P3/04 , A61P25/24 , C07D217/24
CPC分类号： A61K31/397 , A61K31/4704 , A61K31/5377 , C07D209/46 , C07D209/48 , C07D217/24 , C07D401/06
摘要： In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及双环mGluR5阳性变构调节剂，例如6-（苯基乙炔基）-3,4-二氢异喹啉-1（2H） - 酮及其衍生物和相关化合物，其可用作阳性变构调节剂 代谢型谷氨酸受体亚型5（mGluR5）; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
-
-
-
-
-
-
-
-
-
搜索结果
104 条记录 (耗时 0.063 秒)
