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公开(公告)号：US20220026201A1
公开(公告)日：2022-01-27
申请号：US16937826
申请日：2020-07-24
申请人： Andrew Thomas
发明人： Andrew Thomas
摘要： Examples of the present subject matter provide techniques for measuring thicknesses of materials using one or more acquisition cycles. The data from the one or more acquisition cycles may be amplified using a specified gain across the signal response, converted to a digital signal, and stored in a memory. The digital signal may be retrieved from memory, and signal processing techniques using one or more time variable threshold(s) may be used to calculate one or more thickness(es) of the testing object.
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92.发明授权Method and circuitry for removing circling drifts in NDT/NDI measurement display 有权用于去除NDT / NDI测量显示中的环状漂移的方法和电路公开(公告)号：US09350985B2
公开(公告)日：2016-05-24
申请号：US14036078
申请日：2013-09-25
申请人： Andrew Thomas
发明人： Andrew Thomas
CPC分类号： H04N17/004 , G01N27/9046
摘要： Disclosed is a method and an apparatus for removing circling drifts on the display of the measured eddy current or other continuous waves. The circling dot which is supposed to be a static dot can obscure information required by the operator to judge if a small defect is present. Embodiments of presently disclosed harmonic rejection filters are tunable and employed to effectively abate or eliminate signals with frequencies that are multiples of operating frequencies, resulting in the removal of the circling effects on the display.
摘要翻译： 公开了一种用于去除测量的涡流或其他连续波的显示器上的循环漂移的方法和装置。 假定为静点的盘旋点可能会掩盖操作者所需的信息，以判断是否存在小的缺陷。 目前公开的谐波抑制滤波器的实施例是可调谐的并且用于有效地消除或消除具有工作频率倍数的频率的信号，导致在显示器上消除盘旋效应。
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公开(公告)号：US09063174B2
公开(公告)日：2015-06-23
申请号：US14077322
申请日：2013-11-12
申请人： Andrew Thomas , Steven Besser
发明人： Andrew Thomas , Steven Besser
CPC分类号： G01R1/44 , G01B7/10 , G01D3/0365 , G01D5/142 , G01R33/0035 , G01R33/0082 , G01R33/072
摘要： Disclosed is a Hall Effect instrument with the capability of compensating for temperature drift consistently, accurately and in real time of operation. The instrument embodies a four-point ohm meter circuit measuring Hall Effect sensor resistance and tracking the effect of temperature on the Hall Effect sensor. The instrument takes into account a relationship between the temperature and a temperature compensation index on a per probe basis, which has exhibited a deterministic difference observed by the present inventor.
摘要翻译： 公开了一种霍尔效应仪器，其能够一致，准确和实时地补偿温度漂移。 该仪器体现了四点欧姆表电路，测量霍尔效应传感器电阻并跟踪温度对霍尔效应传感器的影响。 该仪器考虑了基于每个探针的温度和温度补偿指数之间的关系，其显示出本发明人观察到的确定性差异。
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公开(公告)号：US20150142356A1
公开(公告)日：2015-05-21
申请号：US14601961
申请日：2015-01-21
申请人： Andrew Thomas , Steven Besser
发明人： Andrew Thomas , Steven Besser
CPC分类号： G01R33/072 , G01B7/10 , G01D3/0365 , G01D5/142 , G01R1/44 , G01R33/0035 , G01R33/0082 , G01R35/00
摘要： Disclosed is a Hall Effect instrument with the capability of compensating for temperature drift consistently, accurately and in real time of operation. The instrument embodies a four-point ohmmeter circuit measuring Hall Effect sensor resistance and tracking the effect of temperature on the Hall Effect sensor. The instrument takes into account a relationship between the temperature and a temperature compensation index on a per probe basis, which has exhibited a deterministic difference observed by the present inventor.
摘要翻译： 公开了一种霍尔效应仪器，其能够一致，准确和实时地补偿温度漂移。 该仪器体现了四点欧姆表电路，测量霍尔效应传感器电阻，并跟踪温度对霍尔效应传感器的影响。 该仪器考虑了基于每个探针的温度和温度补偿指数之间的关系，其显示出本发明人观察到的确定性差异。
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公开(公告)号：US20140132254A1
公开(公告)日：2014-05-15
申请号：US14077322
申请日：2013-11-12
申请人： Andrew Thomas , Steven Besser
发明人： Andrew Thomas , Steven Besser
IPC分类号： G01R1/44
CPC分类号： G01R1/44 , G01B7/10 , G01D3/0365 , G01D5/142 , G01R33/0035 , G01R33/0082 , G01R33/072
摘要： Disclosed is a Hall Effect instrument with the capability of compensating for temperature drift consistently, accurately and in real time of operation. The instrument embodies a four-point ohm meter circuit measuring Hall Effect sensor resistance and tracking the effect of temperature on the Hall Effect sensor. The instrument takes into account a relationship between the temperature and a temperature compensation index on a per probe basis, which has exhibited a deterministic difference observed by the present inventor.
摘要翻译： 公开了一种霍尔效应仪器，其能够一致，准确和实时地补偿温度漂移。 该仪器体现了四点欧姆表电路，测量霍尔效应传感器电阻并跟踪温度对霍尔效应传感器的影响。 该仪器考虑了基于每个探针的温度和温度补偿指数之间的关系，其显示出本发明人观察到的确定性差异。
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96.发明授权Extended overflow indication for high dynamic range ultrasonic fault detection systems 有权用于高动态范围超声波故障检测系统的扩展溢出指示公开(公告)号：US08490491B2
公开(公告)日：2013-07-23
申请号：US12712464
申请日：2010-02-25
申请人： Andrew Thomas
发明人： Andrew Thomas
CPC分类号： G01N29/44 , G01N29/043 , G01N29/262 , G01N29/42 , G01N29/4463 , G01N2291/044 , G01N2291/102 , H03M1/188
摘要： A method and apparatus for effecting ultrasonic flaw detection of an object processes an echo signal received from the object being tested in at least three signal channels, wherein the echo signal is scaled to different degrees along each channel to increase and extend the dynamic range of an associated A/D converter system, in a manner which dispenses with the need for using numerous analog high pass and low pass filters and a variable gain amplifier. This reduces complexity and avoids performance limitations. The digital to analog converters sample the differently scaled input signal and a selection circuit selects the output of the digital output obtained from that analog to digital converter which has the highest gain, but which has not overflowed. The digital outputs are seamlessly merged to produce an output that can be displayed as a scan display which shows the location of faults.
摘要翻译： 用于实现物体的超声波探伤的方法和装置处理在至少三个信号通道中从被测试对象接收的回波信号，其中回波信号沿着每个通道被缩放到不同程度，以增加和扩展一个 相关的A / D转换器系统，其不需要使用大量模拟高通和低通滤波器和可变增益放大器。 这降低了复杂性并避免了性能限制。 数模转换器对不同比例的输入信号进行采样，并且选择电路选择从具有最高增益但尚未溢出的模数转换器获得的数字输出的输出。 数字输出无缝合并，产生可显示为显示故障位置的扫描显示的输出。
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公开(公告)号：US08415379B2
公开(公告)日：2013-04-09
申请号：US12768762
申请日：2010-04-28
IPC分类号： A61K31/443 , C07D413/14
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention is concerned with isoxazole-pyridines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as pharmaceuticals. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
摘要翻译： 本发明涉及式I的异恶唑 - 吡啶，对GABA Aα5受体具有亲和性和选择性，其制备方法，含有它们的药物组合物及其作为药物的用途。 本发明的活性化合物可用作认知增强剂或用于治疗和/或预防性治疗认知障碍如阿尔茨海默氏病。
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公开(公告)号：US08357703B2
公开(公告)日：2013-01-22
申请号：US12772250
申请日：2010-05-03
IPC分类号： A61K31/4427 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention is concerned with novel isoxazoles of formula I wherein X, R1, R2, R3 and R4 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as therapeutics.
摘要翻译： 本发明涉及式I的新异恶唑，其中X，R 1，R 2，R 3和R 4如本文所述，以及其药学上可接受的盐和酯。 本发明的活性化合物对GABA Aα5受体具有亲和性和选择性。 此外，本发明涉及制备式I的活性化合物，含有它们的药物组合物及其作为治疗剂的用途。
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公开(公告)号：US20120225884A1
公开(公告)日：2012-09-06
申请号：US13405404
申请日：2012-02-27
申请人： Karlheinz Baumann , Luke Green , Anja Limberg , Thomas Luebbers , Andrew Thomas
发明人： Karlheinz Baumann , Luke Green , Anja Limberg , Thomas Luebbers , Andrew Thomas
IPC分类号： A61K31/4985 , C07D451/04 , C07D487/04 , A61P25/00 , A61K31/437 , A61K31/506 , A61K31/519 , A61P25/28 , C07D471/04 , A61K31/444
CPC分类号： C07D451/04
摘要： The present invention relates to compounds of formula I hetaryl I, hetaryl II, R1, R2, R3, Y, m, and o or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
摘要翻译： 本发明涉及式I化合物，杂芳基I，杂芳基II，R 1，R 2，R 3，Y，m和o的化合物或其药物活性酸加成盐。 本发明式I化合物是淀粉样蛋白β的调节剂，因此它们可用于治疗或预防与脑中淀粉样蛋白沉积相关的疾病，特别是阿尔茨海默氏病和其他疾病如脑 淀粉样血管病，淀粉样变性遗传性脑出血，荷兰型（HCHWA-D），多发性梗死性痴呆，痴呆和唐氏综合征。
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公开(公告)号：US08178522B2
公开(公告)日：2012-05-15
申请号：US12768779
申请日：2010-04-28
IPC分类号： A61K31/397 , A61K31/427 , A61K31/4439 , A61K31/541 , A61K31/5377 , C07D417/06 , C07D417/14
CPC分类号： C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
摘要翻译： 本发明涉及式I的异恶唑 - 噻唑衍生物，其具有对GABA Aα5受体的亲和性和选择性，它们的制备，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用作认知增强剂或用于治疗和/或预防性治疗认知障碍如阿尔茨海默氏病。
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