公开(公告)号：US11287427B2

公开(公告)日：2022-03-29

申请号：US16620747

申请日：2018-06-11

Applicant: VANDERBILT UNIVERSITY ,  THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

Inventor： Alvin C. Powers ,  Marcela Brissova ,  Chunhua Dai ,  Neil Phillips ,  Diane Saunders

IPC: G01N33/573 ,  A61K35/39 ,  G01N33/569 ,  C07K16/40 ,  G01N33/543

Abstract: In spite of significant efforts to identify β-cell-specific markers for β-cell imaging and purification, progress has been limited. Herein is disclosed a novel biomarker of human pancreatic β-cells, CD39L3 (also known as ectonucleoside triphosphate diphosphohydrolase-3 (NTPDase3)). Disclosed are compositions and methods for purifying and imaging β-cell using anti-CD39L3 antibodies.

公开(公告)号：US11268100B2

公开(公告)日：2022-03-08

申请号：US16093808

申请日：2017-04-14

Applicant: VANDERBILT UNIVERSITY

Inventor： Sarah R. Bordenstein ,  Seth R. Bordenstein

IPC: C12N15/74 ,  C12N15/86

Abstract: The invention relates to systems, methods, and compositions for the genetic modification of Wolbachia.

公开(公告)号：US20220061929A1

公开(公告)日：2022-03-03

申请号：US17421558

申请日：2020-01-10

Applicant: Vanderbilt University

Inventor： Yuankai Tao ,  Mohamed T. El-Haddad

IPC: A61B34/20 ,  G06T7/70 ,  G06T3/40 ,  G01B9/02 ,  G02B26/10 ,  G06N3/08 ,  G16H30/40

Abstract: Systems and methods for image-based guidance using automated instrument tracking. An en face image frame, generated from en face image data captured by a first imaging system (e.g., an SER imaging system), is analyzed to determine a location of an instrument in the first imaging plane. A control signal is then generated for the movement stage to control the scanning movement of a depth-based imaging system (e.g., an OCT imaging system) based on the determined location of the instrument. In some implementations, a trained neural-network is used to determine the location of the instrument based on the en face image frame and, in some implementations, the control signal adjusts the speed of the scanning movement to capture image data at a higher density7 at areas corresponding to the determined location of the instrument.

公开(公告)号：US20220054494A1

公开(公告)日：2022-02-24

申请号：US17434894

申请日：2020-03-13

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Vanderbilt University ,  The Trustees of The University of Pennsylvania

Inventor： Edwin Kerry Jackson ,  Lori Ann Birder ,  Amanda Sue Wolf-Johnston ,  Roger Dmochowski ,  Alan J. Wein

IPC: A61K31/522 ,  A61K9/00 ,  A61P13/10

Abstract: Methods of treating bladder or urethra dysfunction or disease in a subject and methods of increasing bladder smooth muscle contractility or increasing bladder wall volume in a subject are disclosed. In some examples, a purine nucleoside phosphorylase (PNPase) inhibitor or purine nucleoside substrate is administered, such as 8-aminoguanine or forodesine.

公开(公告)号：US20220032052A1

公开(公告)日：2022-02-03

申请号：US17278807

申请日：2020-03-06

Applicant: Vanderbilt University

Inventor： David KENT

IPC: A61N1/36 ,  A61N1/05

Abstract: Methods and systems of treating sleep disordered breathing in a patient suffering therefrom by activating one or more infrahyoid strap muscles are provided. Activation of one or more infrahyoid muscles can be accomplished by stimulating an ansa cervicalis, including one or both of the superior root and the inferior root of the ansa cervicalis, alone or in combination with stimulating the hypoglossal nerve.

公开(公告)号：US20220015825A1

公开(公告)日：2022-01-20

申请号：US17294753

申请日：2019-11-20

Applicant: Vanderbilt University

Inventor： William D. MERRYMAN ,  Joshua GAFFORD ,  Matthew BERSI ,  Gregory MICHAUD ,  Robert WEBSTER

IPC: A61B18/14

Abstract: One aspect of the present disclosure includes a sheath configured to receive an ablation probe. The sheath includes a temperature-controlled anchor element thereon configured to attach the sheath to bodily tissue.

公开(公告)号：US20220008346A1

公开(公告)日：2022-01-13

申请号：US17290618

申请日：2019-10-30

Applicant: Vanderbilt University

Inventor： John T. Wilson ,  Daniel Shae ,  Dinh Chuong Nguyen

IPC: A61K9/50 ,  C08F290/06

Abstract: A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.

公开(公告)号：US20220007997A1

公开(公告)日：2022-01-13

申请号：US17289323

申请日：2019-11-04

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. MANNOH ,  Anita MAHADEVAN-JANSEN

IPC: A61B5/00 ,  G01N21/64 ,  G01N21/65 ,  A61B34/20

Abstract: A combined auto-fluorescence imaging and laser speckle contrast imaging (LSCI) system to enable intra-operative parathyroid identification and viability assessment with the same tool. The system includes a light source for emitting a beam of light to illuminate a target of interest, and an imaging head positioned over the target of interest for individually acquiring auto-fluorescence images and LSCI images of light from the illuminated target of interest responsive to the illumination. Auto-fluorescence imaging helps identify the parathyroid, while LSCI helps assess its viability.

公开(公告)号：US11213408B2

公开(公告)日：2022-01-04

申请号：US17144418

申请日：2021-01-08

Applicant: VANDERBILT UNIVERSITY

Inventor： Michael Goldfarb ,  Harrison Bartlett ,  Brian Lawson

IPC: F15B1/02 ,  A61F2/68 ,  A61F2/66 ,  A61F2/70 ,  F15B11/10 ,  F15B15/08 ,  F15B15/14 ,  F15B15/20 ,  F16H25/20 ,  A61F2/74

Abstract: An asymmetric linear actuator is provided which integrates a hydraulic dissipater and an electric motor and power screw which generates small forces. The actuator is configured so that an electric motor drives a power screw which drives a rod through a cylinder to provide linear actuation. The cylinder is fluid-filled and incorporates a piston that separates the cylinder into a first and second fluid chamber which are filled with a first and second volume of working fluid. Movement of the piston and rod assembly results in fluid movement between the first and second volumes of working fluid and through the fluidic restriction. The fluidic restriction can be proportionally controllable via an electric motor which enables controllable power dissipation via control of the fluidic restriction motor and controllable power generation via control of the power screw motor.

公开(公告)号：US11208415B2

公开(公告)日：2021-12-28

申请号：US16688872

申请日：2019-11-19

Applicant: Vanderbilt University

Inventor： Taekyu Lee ,  Zhiguo Bian ,  Johannes Belmar ,  Plamen P. Christov ,  Nicholas F. Pelz ,  Subrata Shaw ,  Kwangho Kim ,  James C. Tarr ,  Edward T. Olejniczak ,  Bin Zhao ,  Stephen W. Fesik

IPC: C07D487/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/14 ,  C07D209/42 ,  A61K31/551 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/498 ,  C07D409/14 ,  C07D471/04 ,  C07D409/12 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.