公开(公告)号：US20150279082A1

公开(公告)日：2015-10-01

申请号：US14184446

申请日：2014-02-19

Applicant: Howard University

Inventor： John M. M. Anderson ,  Mandoye Ndoye

IPC: G06T15/08 ,  G01S7/04 ,  G01S13/88

CPC classification number: G06T15/08 ,  G01S7/046 ,  G01S7/295 ,  G01S13/003 ,  G01S13/885 ,  G01S13/90

Abstract: A majorize-minimize (MM) mathematical principle is applied to least squares regularization estimation problems to effect efficient processing of image data sets to provide good quality images. In a ground penetrating radar application, these approaches can reduce processing time and memory use by accounting for a symmetric nature of a given radar pulse, accounting for similar discrete time delays between transmission of a given radar pulse and reception of reflections from the given radar pulse, and accounting for a short duration of the given radar pulse.

Abstract translation: 主要最小化（MM）数学原理被应用于最小二乘法正则化估计问题，以实现图像数据集的有效处理，以提供高质量的图像。 在地面穿透雷达应用中，这些方法可以通过考虑给定雷达脉冲的对称性来减少处理时间和存储器使用，考虑给定雷达脉冲的传输和从给定的雷达脉冲接收反射之间的类似的离散时间延迟 ，并且考虑给定雷达脉冲的短时间。

公开(公告)号：US20150119429A1

公开(公告)日：2015-04-30

申请号：US14399646

申请日：2013-03-14

Applicant: Howard University

Inventor： Sergei Nekhai ,  Dmytro Borisovych Kovalskyy

IPC: C07D213/59

CPC classification number: C07D213/59 ,  C07C337/08 ,  C07D213/53

Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.

Abstract translation: 本发明涉及用于螯合金属离子的螯合剂化合物。 特别地，本发明涉及作为金属离子（包括铁离子）的螯合剂的（硫代）缩氨基脲化合物和（硫代）腙化合物，例如PpYeT和PpYaT。 这些化合物和/或其金属离子配合物的治疗用途包括用于治疗和抑制HIV-1复制的方法，特别是在HIV-1感染的细胞中。