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公开(公告)号：US08974772B2
公开(公告)日：2015-03-10
申请号：US11023968
申请日：2004-12-28
Applicant: Linh Fruge , James R. Brown , Susan Herles , Kimberlee Panaligan , Evangelia S. Arvanitidou , Nebojsa Milanovich , Michael Prencipe
Inventor： Linh Fruge , James R. Brown , Susan Herles , Kimberlee Panaligan , Evangelia S. Arvanitidou , Nebojsa Milanovich , Michael Prencipe
CPC classification number: A61K8/21 , A61K8/19 , A61K8/347 , A61K2800/88 , A61Q11/00
Abstract: An oral care composition having a first phase of clinically efficacious 2,4,4′-trichloro 2′-hydroxydiphenyl ether admixed in a first orally acceptable aqueous vehicle, and a second phase having a stannous salt (such as stannous fluoride) admixed in a second orally acceptable aqueous vehicle. The second phase has no less than 10 molar percent of soluble stannous ion respective to a mathematical sum of moles of the soluble stannous ion and moles of the stannous salt in the second phase. In one embodiment, the two phases are provided in a dual-tube toothpaste oral care kit.
Abstract translation: 一种口腔护理组合物，其具有混合在第一口服可接受的水性载体中的临床上有效的2,4,4'-三氯2'-羟基二苯醚的第一相，和在其中混合的具有亚锡盐（例如氟化亚锡）的第二相 第二种口服可接受的水性载体。 第二相具有不少于10摩尔％的可溶性亚锡离子，相对于第二相中可溶性亚锡离子的摩尔数和亚锡盐的摩尔数的数学和。 在一个实施方案中，将两相设置在双管牙膏口腔护理套件中。
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公开(公告)号：US20140341816A1
公开(公告)日：2014-11-20
申请号：US14365113
申请日：2011-12-16
Applicant: Gregory Szewczyk , Neeta Atul Patel , Suzanne Jogun , Michael Prencipe
Inventor： Gregory Szewczyk , Neeta Atul Patel , Suzanne Jogun , Michael Prencipe
CPC classification number: A61K49/00 , A61K8/0204 , A61K8/0233 , A61K8/345 , A61K8/4993 , A61K8/731 , A61K8/732 , A61K2800/43 , A61Q11/00 , B65D35/00
Abstract: Described herein are dentifrices comprising a first formulation and a second formulation, wherein the formulations are coaxially extruded, so that the first formulation enrobes the second formulation, wherein the first formulation is opaque and wherein the second formulation comprises dissolvable film fragments, together with methods of making and using the same and containers for providing the same.
Abstract translation: 本文描述的是包含第一制剂和第二制剂的洁齿剂，其中所述制剂被同轴挤出，使得第一制剂对第二制剂进行了刺激，其中第一制剂是不透明的，其中第二制剂包含可溶性膜片段， 使用和使用相同的容器提供相同的容器。
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公开(公告)号：US20140322141A1
公开(公告)日：2014-10-30
申请号：US14365116
申请日：2011-12-16
Applicant: Gregory Szewczyk , Neeta Atul Patel , Suzanne Jogun , Michael Prencipe
Inventor： Gregory Szewczyk , Neeta Atul Patel , Suzanne Jogun , Michael Prencipe
CPC classification number: A61K8/58 , A61K8/02 , A61K8/0216 , A61K8/494 , A61K8/731 , A61K2800/43 , A61K2800/58 , A61Q11/00
Abstract: Described herein are compositions comprising a film, wherein the film comprises a pigment, and is adapted to release the pigment at a specific point in time during use; and methods of making and using the same.
Abstract translation: 本文描述的是包含膜的组合物，其中所述膜包含颜料，并且适于在使用期间在特定时间点释放颜料; 以及制作和使用它们的方法。
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公开(公告)号：US08815216B2
公开(公告)日：2014-08-26
申请号：US11403732
申请日：2006-04-13
Applicant: Michael Prencipe , Suman Chopra , Joseph Thomas Norris , Adolfo Serrano
Inventor： Michael Prencipe , Suman Chopra , Joseph Thomas Norris , Adolfo Serrano
CPC classification number: A61C19/066 , A46B9/005 , A46B9/021 , A46B9/025 , A46B11/0024 , A46B11/0027 , A46B17/04 , A46B2200/10 , A46B2200/1046 , A46B2200/20 , A61C1/0092 , A61C3/005 , A61C17/0202 , A61C19/063 , A61K8/22 , A61K8/8147 , A61K2800/87 , A61K2800/92 , A61Q11/00
Abstract: The method of the present invention is directed to the storage and dispensing of a peroxide containing tooth whitening composition. During storage and subsequent use the composition in the storage chamber must be maintained segregated from the applicator surface. This is accomplished by delivering the peroxide containing tooth whitening composition from the storage chamber through a delivery channel having a length and a cross-sectional diameter sufficient to preclude the migration of moisture and the enzyme catalase from the application surface to the storage chamber. The composition is applied to teeth by means of bristles, a sponge surface or fibrillated surface. This applicator can be used with both aqueous and non-aqueous peroxide containing tooth whitening compositions.
Abstract translation: 本发明的方法涉及含过氧化物的牙齿增白组合物的储存和分配。 在储存和随后使用期间，储存室中的组合物必须保持与施用器表面分离。 这是通过将来自储存室的含过氧化物的牙齿增白组合物通过具有足以防止水分和酶过氧化氢酶从施用表面迁移到储存室的长度和横截面直径的输送通道来实现的。 组合物通过刷毛，海绵表面或原纤化表面施加到牙齿上。 该施用器可以与含水和非水过氧化物含有牙齿美白组合物一起使用。
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公开(公告)号：US08591868B2
公开(公告)日：2013-11-26
申请号：US13296282
申请日：2011-11-15
Applicant: Suman K. Chopra , Lynette Zaidel , Michael Prencipe
Inventor： Suman K. Chopra , Lynette Zaidel , Michael Prencipe
CPC classification number: A61K8/22 , A61K8/20 , A61K8/25 , A61K8/463 , A61K8/737 , A61K8/8152 , A61K8/8176 , A61K8/86 , A61K8/88 , A61K8/89 , A61Q11/00
Abstract: The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.
Abstract translation: 本发明提供了一种单相增白洁齿剂，其包括（i）选自过氧化氢，结合过氧化物和固体过氧化物的增白剂（ii）研磨剂和（iii）基本上无水的口服可接受的载体，例如 ， 聚乙二醇。 结合过氧化物可以是过氧化氢和聚合物和/或任何过氧化物化合物和多孔交联聚合物，例如聚乙烯吡咯烷酮聚合物，聚丙烯酸酯，聚甲基丙烯酸酯和多赖氨酸盐。 固体过氧化物可以是过硼酸钠或过氧化脲。 本发明还提供了通过使表面与组合物接触而使牙齿表面变白的方法。
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Patent Agency Ranking
公开(公告)号：US20130216485A1
公开(公告)日：2013-08-22
申请号：US13882494
申请日：2010-11-04
Applicant: Thomas S. Campbell , Steven W. Fisher , Michael Prencipe
Inventor： Thomas S. Campbell , Steven W. Fisher , Michael Prencipe
CPC classification number: A61K8/55 , A61K8/27 , A61K8/347 , A61K8/365 , A61K8/8111 , A61K2800/58 , A61Q11/00
Abstract: A dentifrice composition containing, in combination, an orally acceptable vehicle; a halogenated diphenyl ether; a soluble zinc salt; and a chelating agent to reduce astringency.
Abstract translation: 一种洁牙剂组合物，其组合物包含口服可接受的载体; 卤代二苯醚; 可溶性锌盐; 和螯合剂以减少涩味。
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107.发明授权公开(公告)号：US08481004B2
公开(公告)日：2013-07-09
申请号：US12094817
申请日：2006-11-21
Applicant: James R. Brown , Linh Fruge , Tao Xu , Michael Prencipe
Inventor： James R. Brown , Linh Fruge , Tao Xu , Michael Prencipe
CPC classification number: A61K8/21 , A61K8/03 , A61K8/19 , A61K8/20 , A61K8/24 , A61K8/25 , A61K8/55 , A61K8/69 , A61K8/8164 , A61K2800/28 , A61K2800/591 , A61Q11/00
Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.
Abstract translation: 提供含有亚锡盐和三聚磷酸钠的口腔护理组合物，其中三聚磷酸三钠离子中间体包含少于组合物的约1％焦磷酸四钠，甲基乙烯基醚 - 马来酸酐共聚物和/或二氧化硅口服抛光剂可用于进一步的功效 。 在单相共混物中，口腔护理组合物可以有效地限制为包含小于约10％的水。 在双相混合物中，在牙齿保健使用之前，可以从双室存储管（每个相位由独立的室提供）产生具有第一相中的亚锡盐和第二相中的三聚磷酸钠的混合物。
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108.发明申请ANTIBACTERIAL DENTIFRICE EXHIBITING ENHANCED ANTIPLAQUE AND BREATH FRESHENING PROPERTIES 审中-公开抗菌素抗生素和抗生素的抗菌性能公开(公告)号：US20120141388A1
公开(公告)日：2012-06-07
申请号：US13372871
申请日：2012-02-14
Applicant: Lori H. Szeles , Xiaoyan Liu , Malcolm Williams , M. Teresa R. Carale , Michael Prencipe , James G. Masters
Inventor： Lori H. Szeles , Xiaoyan Liu , Malcolm Williams , M. Teresa R. Carale , Michael Prencipe , James G. Masters
Abstract: An abrasive dentifrice composition which effects enhanced antiplaque and breath freshening properties which comprises an orally acceptable vehicle containing a combination of a safe and effective amount of an antibacterial agent and at least two enzyme ingredients.
Abstract translation: 一种具有增强的抗牙斑和呼吸清新性能的研磨性洁齿剂组合物，其包含含有安全有效量的抗菌剂和至少两种酶成分的组合的口服可接受的载体。
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公开(公告)号：US20120058059A1
公开(公告)日：2012-03-08
申请号：US13296282
申请日：2011-11-15
Applicant: Suman K. Chopra , Lynette Zaidel , Michael Prencipe
Inventor： Suman K. Chopra , Lynette Zaidel , Michael Prencipe
CPC classification number: A61K8/22 , A61K8/20 , A61K8/25 , A61K8/463 , A61K8/737 , A61K8/8152 , A61K8/8176 , A61K8/86 , A61K8/88 , A61K8/89 , A61Q11/00
Abstract: The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.
Abstract translation: 本发明提供了一种单相增白洁齿剂，其包括（i）选自过氧化氢，结合过氧化物和固体过氧化物的增白剂（ii）研磨剂和（iii）基本上无水的口服可接受的载体，例如 ， 聚乙二醇。 结合过氧化物可以是过氧化氢和聚合物和/或任何过氧化物化合物和多孔交联聚合物，例如聚乙烯吡咯烷酮聚合物，聚丙烯酸酯，聚甲基丙烯酸酯和多赖氨酸盐。 固体过氧化物可以是过硼酸钠或过氧化脲。 本发明还提供了通过使表面与组合物接触而使牙齿表面变白的方法。
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公开(公告)号：US20120052025A1
公开(公告)日：2012-03-01
申请号：US13319809
申请日：2010-06-03
Applicant: Venda Porter , Andre Morgan , Stanislav Jaracz , Jennifer Gronlund , Guofeng Xu , Donghui Wu , Michael Prencipe , Ravi Subramanyam
Inventor： Venda Porter , Andre Morgan , Stanislav Jaracz , Jennifer Gronlund , Guofeng Xu , Donghui Wu , Michael Prencipe , Ravi Subramanyam
IPC: A61K31/69 , A61P31/00 , A61P17/02 , A61P31/04 , A61P29/00 , A61Q19/10 , A61Q5/02 , A61Q11/00 , A61K8/58 , A61P17/10
CPC classification number: A61Q11/00 , A61K8/58 , A61K31/69 , A61Q17/005 , Y10S514/835
Abstract: A stabilized topical composition comprising a borinic acid derivative, e.g., a borinic ester.
Abstract translation: 包含硼酸衍生物例如硼酸酯的稳定的局部组合物。
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