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    Integrated cardiac rhythm management system with heart valve
    101.
    发明授权
    Integrated cardiac rhythm management system with heart valve 有权
    心脏心脏综合心律管理系统

    公开(公告)号：US08504151B2

    公开(公告)日：2013-08-06

    申请号：US13564978

    申请日：2012-08-02

    申请人： Allan C. Shuros ,  Michael J. Kane

    发明人： Allan C. Shuros ,  Michael J. Kane

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3621 ,  A61F2/2403 ,  A61N1/36514 ,  A61N1/3962

    摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.

    摘要翻译： 使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。 心脏管理系统包括具有生理传感器的心脏瓣膜。 生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。 该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。 电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。

    Sympathetic stimulation for improved myocardial relaxation
    102.
    发明授权
    Sympathetic stimulation for improved myocardial relaxation 有权
    改善心肌松弛的交感刺激

    公开(公告)号：US08498704B2

    公开(公告)日：2013-07-30

    申请号：US13019818

    申请日：2011-02-02

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Guy Alvarez

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Guy Alvarez

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/365

    摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.

    摘要翻译： 描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。 这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。 描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。

    Deactivation of intermittent pacing therapy
    103.
    发明授权
    Deactivation of intermittent pacing therapy 失效
    间歇性起搏治疗的停用

    公开(公告)号：US08483826B2

    公开(公告)日：2013-07-09

    申请号：US12405990

    申请日：2009-03-17

    申请人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    发明人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3627 ,  A61N1/368 ,  A61N1/3688 ,  A61N1/3962

    摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when pacing is changed from the normal operating mode to a stress augmentation mode. The pacing mode controller suspends the change from the normal operating mode to the stress augmentation mode when a condition to prevent the change is detected.

    摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当起搏从正常操作模式改变为应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。 当检测到防止变化的条件时，起搏模式控制器将更改从正常操作模式暂停到应力增强模式。

    Reduction of AV delay for treatment of cardiac disease
    105.
    发明授权
    Reduction of AV delay for treatment of cardiac disease 有权
    减少AV延迟治疗心脏病

    公开(公告)号：US08311630B2

    公开(公告)日：2012-11-13

    申请号：US13229948

    申请日：2011-09-12

    申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

    发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Julio C. Spinelli ,  Allan C. Shuros ,  Andres Belalcazar

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3688

    摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.

    摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

    Integrated cardiac rhythm management system with heart valve
    107.
    发明授权
    Integrated cardiac rhythm management system with heart valve 有权
    心脏心脏综合心律管理系统

    公开(公告)号：US08239023B2

    公开(公告)日：2012-08-07

    申请号：US12645934

    申请日：2009-12-23

    申请人： Allan C. Shuros ,  Michael J. Kane

    发明人： Allan C. Shuros ,  Michael J. Kane

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3621 ,  A61F2/2403 ,  A61N1/36514 ,  A61N1/3962

    摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.

    摘要翻译： 使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。 心脏管理系统包括具有生理传感器的心脏瓣膜。 生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。 该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。 电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。

    CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT
    108.
    发明申请
    CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 有权
    间歇性激素治疗效果的闭环控制

    公开(公告)号：US20120165891A1

    公开(公告)日：2012-06-28

    申请号：US13411945

    申请日：2012-03-05

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Christopher Hartemink

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627

    摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.

    摘要翻译： 用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。 刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。 为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

    Intermittent pacing therapy delivery statistics
    109.
    发明授权
    Intermittent pacing therapy delivery statistics 有权
    间歇性起搏治疗递送统计

    公开(公告)号：US08140155B2

    公开(公告)日：2012-03-20

    申请号：US12401194

    申请日：2009-03-10

    申请人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    发明人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3688

    摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.

    摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。