公开(公告)号：US4659558A

公开(公告)日：1987-04-21

申请号：US571618

申请日：1984-01-17

申请人： John Urquhart ,  Felix Theeuwes

发明人： John Urquhart ,  Felix Theeuwes

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

CPC分类号： A61K9/0065 ,  A61K9/2077

摘要： A delivery device is disclosed for delivering a beneficial drug to a biological environment of use. The device comprises a hydrogel reservoir containing tiny pills. The tiny pills comprise a wall surrounding a drug core.

摘要翻译： 公开了用于将有益药物递送到生物生物学环境的递送装置。 该装置包括含有微小药丸的水凝胶储存器。 微小的药丸包括围绕药物核心的墙壁。

公开(公告)号：US4655766A

公开(公告)日：1987-04-07

申请号：US853262

申请日：1986-04-17

申请人： Felix Theeuwes ,  James B. Eckenhoff

发明人： Felix Theeuwes ,  James B. Eckenhoff

IPC分类号： A61K9/00 ,  A61K9/70

CPC分类号： A61K9/703 ,  A61K9/0004 ,  A61K9/7084

摘要： A medical device comprising a fluid imbibing, self-regulating, skin patch drug delivery system is disclosed which includes a fluid imbibing, preferably osmotic, pump comprising a reservoir for a drug or, drug formulation or other fluid to be dispensed to the skin, 10 at least one wall of the reservoir comprising a fluid permeable membrane which is permeable to an external activating fluid. The external fluid is imbibed through the membrane at a predetermined rate thereby causing the drug to be pumped through one or more passages provided in the reservoir structure and 15 into contact with the skin. The device includes an impermeable exterior wall member which covers and extends outwardly from the fluid imbibing pump terminating in an edge portion adapted to be secured, as by adhesion, to the skin. The exterior wall member, when attached to the skin surface, defines the area of skin which is available for distribution of the drug formulation pumped from the reservoir which is large enough, at the lowest anticipated skin permeation, to deliver the drug to the body at the rate at which it is discharged from the fluid imbibing pump in the preferred embodiments the fluid permeable membrane is a semipermeable membrane, impermeable to the drug or drug formulation.

摘要翻译： 公开了一种包括流体吸收的自调节皮肤贴片药物递送系统的医疗装置，其包括流体吸收，优选渗透泵，其包括用于药物或药物制剂或将被分配到皮肤的其它流体的储存器10 储存器的至少一个壁包括可渗透外部活化流体的流体可渗透膜。 外部流体以预定的速率吸入膜中，从而使得药物被泵送通过设置在储存器结构和15中的一个或多个通道与皮肤接触。 该装置包括不透水的外壁构件，其从流体吸收泵向外覆盖并向外延伸，终止于边缘部分，其适于通过粘附固定到皮肤上。 外壁构件在附着于皮肤表面时限定了皮肤的面积，其可用于分配从储存器抽出的药物制剂，该药剂配制剂足够大，以最低的预期皮肤渗透率将药物递送至身体 在优选实施例中，其从流体吸入泵排出的速率，流体可渗透膜是对药物或药物制剂不可渗透的半透膜。

公开(公告)号：US4627850A

公开(公告)日：1986-12-09

申请号：US548219

申请日：1983-11-02

申请人： Joseph C. Deters ,  Felix Theeuwes ,  Kevin J. Mullins ,  James B. Eckenhoff

发明人： Joseph C. Deters ,  Felix Theeuwes ,  Kevin J. Mullins ,  James B. Eckenhoff

IPC分类号： A01N25/10 ,  A01N25/34 ,  A61J3/07 ,  A61K8/00 ,  A61K8/11 ,  A61K8/18 ,  A61K8/73 ,  A61K9/00 ,  A61K9/52 ,  A61L9/04 ,  A61M31/00 ,  A61Q13/00 ,  A61Q19/10 ,  B01J4/04 ,  C11B9/00

CPC分类号： A61K9/0004 ,  Y10S526/93 ,  Y10T428/249958 ,  Y10T428/249988 ,  Y10T428/31772

摘要： An osmotic capsule is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic capsule comprises an outer semipermeable wall surrounding and laminating an inner capsule wall formed of a different polymeric composition than the outer wall. The walls define an interior space containing the beneficial agent formulation. A passageway through the walls connects the exterior of the osmotic capsule with the interior of the osmotic capsule.

摘要翻译： 公开了一种用于将有益剂制剂递送到使用环境的渗透性胶囊。 渗透性胶囊包括围绕并层压由与外壁不同的聚合物组合物形成的内胶囊壁的外半透壁。 墙壁限定了含有有益剂制剂的内部空间。 穿过墙壁的通道将渗透胶囊的外部与渗透胶囊的内部连接。

公开(公告)号：US4608048A

公开(公告)日：1986-08-26

申请号：US678744

申请日：1984-12-06

申请人： Richard Cortese ,  Felix Theeuwes

发明人： Richard Cortese ,  Felix Theeuwes

IPC分类号： A61K9/00 ,  A61M7/00

CPC分类号： A61K9/0004

摘要： An osmotic device is disclosed for delivering an agent to a selected environment. The device comprises a semipermeable wall surrounding a first and second compartment for containing the agent, and the device is provided with means for delivering the agent from both compartments through a single osmotic passageway.

摘要翻译： 公开了用于将试剂递送到所选择的环境的渗透装置。 该装置包括围绕用于容纳试剂的第一和第二隔室的半透壁，并且该装置设置有用于通过单个渗透通道从两个隔室输送试剂的装置。

公开(公告)号：US4586922A

公开(公告)日：1986-05-06

申请号：US702273

申请日：1985-02-15

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

公开(公告)号：US4576604A

公开(公告)日：1986-03-18

申请号：US472333

申请日：1983-03-04

申请人： George V. Guittard ,  Joseph C. Deters ,  Felix Theeuwes ,  Richard Cortese

发明人： George V. Guittard ,  Joseph C. Deters ,  Felix Theeuwes ,  Richard Cortese

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/58

CPC分类号： A61K9/0004

摘要： An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing an agent, a passageway in the wall connecting the exterior of the device with the compartment, and (a) an agent in the wall or (b) an agent carried on the wall in the wall. The device delivers the agent from the compartment and the wall.

摘要翻译： 公开了用于递送有益剂的渗透装置。 该装置包括围绕包含试剂的隔室的壁，连接装置外部与隔室的通道，和（a）壁中的试剂或（b）承载在墙壁上的试剂。 该设备从隔室和墙壁传送代理。

公开(公告)号：US4521211A

公开(公告)日：1985-06-04

申请号：US576572

申请日：1984-02-03

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

摘要翻译： 公开了胃肠外递送系统和制剂室，用于施用有益剂。 胃肠外输送系统包括滴注室和制剂室。 制剂室包括围绕内部空间的壁，并且其具有用于将液体进入制剂室的入口和用于使制剂制剂离开制剂室的出口。 该室容纳用于将有益剂释放到进入室的液体中的药剂递送系统。

公开(公告)号：US4455143A

公开(公告)日：1984-06-19

申请号：US360396

申请日：1982-03-22

申请人： Felix Theeuwes ,  Brian Barclay ,  Richard Cortese

发明人： Felix Theeuwes ,  Brian Barclay ,  Richard Cortese

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52

CPC分类号： A61K9/0004

摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.

摘要翻译： 公开了用于将两种有益药物递送到使用环境的渗透装置。 该装置包括围绕分隔成包含药物的内腔的半透壁，所述第一隔室含有与含有不同药物的第二隔室分离的药物。 通过该壁的孔与第一隔室连通，用于从第一隔室输送药物，另一个穿过该壁的孔与第二隔室连通，用于从第二隔室输送药物。 在操作中，药物从每个隔室分开分配，流体通过壁被吸入每个隔室中，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物控制，从而在每个隔室中产生 含有药物的溶液在长时间内以受控和连续的速率通过其孔口分配。

公开(公告)号：US4410328A

公开(公告)日：1983-10-18

申请号：US281952

申请日：1981-07-10

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61K9/00 ,  A61M5/145 ,  B65D83/00 ,  A61M7/00

CPC分类号： A61K9/0004 ,  B65D83/00 ,  A61M2005/14513

摘要： A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housng, and (4) an osmotic device in the power compartment or beneath the container.

摘要翻译： 公开了用于递送有益剂的装置。 该装置包括（1）壳体，其限定内部空间（2）壳体中的活塞，该空间将空间分隔成空间中的空间，动力隔室或柔性容器;（3）壳体中的开口， 代理舱或带有外部外壳的容器，以及（4）电源舱或集装箱下方的渗透装置。

公开(公告)号：US4331728A

公开(公告)日：1982-05-25

申请号：US101870

申请日：1979-12-10

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A01N25/10 ,  A01N25/34 ,  A61K9/00 ,  A61K9/22 ,  B32B23/08 ,  B01D39/18 ,  B32B5/22 ,  B32B23/14 ,  B32B23/20

CPC分类号： A61K9/0004 ,  A01N25/10 ,  A01N25/34 ,  B32B23/08 ,  Y10T428/24967 ,  Y10T428/24975 ,  Y10T428/31841 ,  Y10T428/31884 ,  Y10T428/31888 ,  Y10T428/31891

摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.

摘要翻译： 公开了用于递送有益剂的渗透系统。 该系统包括围绕隔室的壁，并且具有通过该壁的通道，用于从隔间输送药剂。 该壁由对外部流体的通道可渗透并且不能透过试剂通过的材料形成。 隔室包含（1）可溶于流体并且穿过壁表现出渗透压梯度相对于流体的试剂，或（2）隔室含有在流体中溶解度有限的试剂，并显示出有限的渗透压梯度 墙壁对着流体。 隔间还包含（1）或（2）个放大器，用于增加从系统传递的代理量。 放大器包括围绕气体发生耦合的膜，膜由可渗透流体并且不可渗透的可膨胀材料形成。 在操作中，通过流体通过壁被吸入到隔室中，通过通道以受控的速率从系统输送试剂，以产生（1）或（2）的悬浮液并由放大器吸收的溶液 该对以产生气体并连续地填充放大器，从而促使其增加体积并填充隔室，由此药剂（1）或（2）以由壁的渗透性控制的速率释放，穿过壁的渗透压梯度 ，以及放大器的吸入速率和放大器的体积增加。