公开(公告)号：US08715191B2

公开(公告)日：2014-05-06

申请号：US12771091

申请日：2010-04-30

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61B8/00 ,  A61B8/06 ,  G01S15/89 ,  G01S7/52

CPC分类号： A61B8/06 ,  A61B8/488 ,  G01S7/52066 ,  G01S7/52071 ,  G01S7/52073 ,  G01S15/8979

摘要： A new approach to processing and displaying received Doppler signals is disclosed. This approach starts with a set of N power spectra corresponding to each of N times. Those power spectra are then used to create of set of pixels for display with respect to an X axis and a Y axis so that the X coordinate of each pixel in the set corresponds to a time and the Y coordinate of each pixel in the set corresponds to a quantized power level. An attribute (e.g., color or intensity) of each pixel in the set is set to represent the highest velocity for the time-and-quantized-power-level combination that corresponds to the X and Y coordinates of each pixel in the set.

摘要翻译： 公开了一种处理和显示接收的多普勒信号的新方法。 这种方法从对应于N次中的每一个的一组N个功率谱开始。 然后，这些功率谱用于创建相对于X轴和Y轴显示的像素组，使得组中每个像素的X坐标对应于时间，并且集合中的每个像素的Y坐标对应于 达到量化的功率水平。 将集合中的每个像素的属性（例如，颜色或强度）设置为表示对应于组中每个像素的X和Y坐标的时间和量化功率级组合的最高速度。

公开(公告)号：US20140088725A1

公开(公告)日：2014-03-27

申请号：US13624050

申请日：2012-09-21

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61F2/04

CPC分类号： A61F2/04 ,  A61M1/1698 ,  A61M1/32 ,  A61M2205/0244 ,  B82Y30/00

摘要： O2 and CO2 can be exchanged with blood by passing the blood through a void within a bundle of nanotubes, where the ends of the nanotubes are open to a gas flow channel. The void in the bundle is configured to form a flow channel that is large enough to permit the red blood cells to flow therethrough. The nanotubes in the bundle are spaced close enough to retain the red blood cells within the flow channel, yet far apart enough to permit blood plasma to flow through spaces between adjoining nanotubes in the bundle, and the nanotubes in the bundle have defects in their walls that permit O2 molecules and CO2 molecules to diffuse therethrough. The defects are present in a sufficient number and total area to effectively deliver O2 to the blood and carry away CO2 from the blood. Alternative embodiments may be used for fluids other than blood.

摘要翻译： 通过使血液通过纳米管束内的空隙，氧气和二氧化碳可与血液交换，其中纳米管的末端向气体流动通道敞开。 束中的空隙被配置成形成足够大的流动通道，以允许红细胞流过其中。 束中的纳米管间隔得足够近，以将红细胞保持在流动通道内，但远离足以允许血浆流过束中的相邻纳米管之间的空间，并且束中的纳米管在其壁中具有缺陷 这允许O 2分子和CO 2分子通过其扩散。 缺陷存在于足够数量和总面积上，以有效地将O2输送到血液中并从血液中携带CO 2。 替代实施例可以用于除血液以外的流体。

公开(公告)号：US20120029419A1

公开(公告)日：2012-02-02

申请号：US13216865

申请日：2011-08-24

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61M37/00

CPC分类号： A61N1/40 ,  A61K31/337 ,  A61K41/0052 ,  A61N1/326

摘要： Chemotherapeutic treatment for certain cancers may be combined with low intensity, intermediate frequency alternating electric fields that are tuned to a particular type of target cell. When the tuned fields were combined with Paclitaxel, Doxorubicin or Cyclophosphamide, excellent results were obtained against human breast cancer cells (MDA-MB-231) and non-small cell lung (H1299) carcinomas in culture. More specifically, cell proliferation inhibition similar to that obtained by drug alone was reached by exposure to the combined treatment at drug concentrations between one and two orders of magnitude lower than for drug-only regimens of treatment.

摘要翻译： 某些癌症的化学治疗可以与被调谐到特定类型的靶细胞的低强度中频交变电场组合。 当调谐场与紫杉醇，多柔比星或环磷酰胺组合时，获得针对培养物中的人乳腺癌细胞（MDA-MB-231）和非小细胞肺（H1299）癌的优异结果。 更具体地，与药物单独获得的细胞增殖抑制类似，通过暴露于药物浓度比药物治疗方案低1至2个数量级的组合治疗来达到。

公开(公告)号：US08027738B2

公开(公告)日：2011-09-27

申请号：US11424115

申请日：2006-06-14

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/40

CPC分类号： A61N1/18 ,  A61N1/40

摘要： An article of clothing is provided for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected to one another by a cleavage furrow. The article of clothing includes insulated electrodes to be coupled to a generator for subjecting the living tissue to electric field conditions sufficient to cause movement of the polarizable intracellular members toward the cleavage furrow in response to a non-homogeneous electric field being induced in the dividing cells. The non-homogeneous electric field produces an increased density electric field in the region of the cleavage furrow. The movement of the polarizable intracellular members towards the cleavage furrow causes the breakdown thereof which adversely impacts the multiplication of the dividing cells.

摘要翻译： 提供了一种服装，用于选择性地破坏由分割细胞和非分裂细胞形成的活组织中的分裂细胞。 分裂细胞含有可极化的细胞内成员，并且在晚期后期或端粒酶期间，分裂细胞通过分裂沟相互连接。 该衣服包括要耦合到发生器的绝缘电极，用于使生物体组织响应于在分裂细胞中诱导的非均匀电场而使足够的可极化细胞内成员向分裂沟移动的电场条件 。 非均匀电场在分裂沟的区域产生增加的密度电场。 可极化细胞内成员向分裂沟的运动导致其破坏，这对分裂细胞的增殖产生不利影响。

公开(公告)号：US07917227B2

公开(公告)日：2011-03-29

申请号：US11537026

申请日：2006-09-29

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/00

CPC分类号： A61N1/32 ,  A61N1/40

摘要： AC electric fields at particular frequencies and field strengths have been shown to be effective for destroying rapidly proliferating cells such as cancer cells. The effectiveness of such fields is improved when the field is sequentially switched between two or more different directions. The effectiveness of such fields can be improved even further by choosing the rate at which the field is switched between the various directions.

摘要翻译： 已经显示特定频率和场强的AC电场对于破坏快速增殖细胞如癌细胞是有效的。 当场在两个或更多个不同方向之间顺序切换时，这种场的有效性得到改善。 通过选择在各个方向之间切换的速率，可进一步提高这些领域的有效性。

公开(公告)号：US07715921B2

公开(公告)日：2010-05-11

申请号：US11294780

申请日：2005-12-05

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/04

CPC分类号： A61N1/0476 ,  A61N1/0408 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/046 ,  A61N1/0492

摘要： As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

摘要翻译： 与常规电极相比，本文所公开的电极构造在使患者的身体长时间放置时能够使对皮肤的刺激和损伤最小化。 电极由涂覆有薄介电材料的导电基底形成，并且多个开放空间通过电极。 这些开放空间是分布和大小的，以便当电极与患者身体接触时允许患者身体表面上的水分逸出。 电极的一个预期用途是通过在长时间内施加具有特定频率和场强特性的AC电场来治疗肿瘤。

公开(公告)号：US07684840B2

公开(公告)日：2010-03-23

申请号：US10524553

申请日：2003-08-07

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61B5/1455

CPC分类号： A61B1/041 ,  A61B5/0084 ,  A61B5/073 ,  A61B5/14546 ,  A61B10/0038 ,  G03B17/02 ,  G03B29/00

摘要： A system for in vivo analysis which includes agglutinative particles capable of interacting with at least one analyte so as to cause an optical change; and at least one in vivo imaging system (220, 230, 240) configured for detecting the optical change in vivo. The system may be incorporated within an ingestible capsule (100).

摘要翻译： 一种用于体内分析的系统，其包括能够与至少一种分析物相互作用以引起光学变化的凝集性颗粒; 以及配置用于检测体内光学变化的至少一个体内成像系统（220,230,240）。 该系统可以结合在可摄取胶囊（100）内。

公开(公告)号：US07519420B2

公开(公告)日：2009-04-14

申请号：US11470555

申请日：2006-09-06

申请人： Yoram Palti

发明人： Yoram Palti

IPC分类号： A61N1/00

CPC分类号： A61N1/18

摘要： Dividing cells within living tissue that contain polarizable intracellular members can be destroyed using at least two insulated electrodes and an electric field source that applies an alternating electric potential across the conductors within the insulated electrodes. The electric field is transformed into a non-homogenous electric field that produces an increased density electric field in a region of the dividing cells. The non-homogenous electric field is of sufficient intensity to cause the intracellular members to be drawn to that region, which causes a pressure increase that results in a structural breakdown of the dividing cells.

摘要翻译： 可以使用至少两个绝缘电极和在绝缘电极内的导体上施加交替电位的电场源来破坏含有可极化细胞内成员的活组织内的细胞分裂。 电场被转换成在均分电场的区域中产生增加的密度电场的非均匀电场。 非均匀电场具有足够的强度以使细胞内成员被吸引到该区域，这导致压力增加，导致分裂细胞的结构破坏。

公开(公告)号：US20090043346A1

公开(公告)日：2009-02-12

申请号：US12190886

申请日：2008-08-13

申请人： Yoram Palti ,  Moshe Giladi

发明人： Yoram Palti ,  Moshe Giladi

IPC分类号： A61K50/00 ,  C12N13/00 ,  A61N1/00

CPC分类号： A61N1/40 ,  A61N1/325 ,  A61N1/326

摘要： Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective disruption of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages or disrupts rapidly dividing cells like parasites, but does not harm normal cells that are not dividing.

摘要翻译： 处于过程部分的电池容易受到具有特定频率和场强特性的交流电场的损害。 因此，快速分裂细胞的选择性破坏可以通过在目标区域中长时间施加AC电场来实现。 一些应用场地分割的细胞将被破坏，但不分裂的细胞不会受到伤害。 这会选择性地损害或破坏快速分裂的细胞，如寄生虫，但不会损害不分裂的正常细胞。

公开(公告)号：US20080319372A1

公开(公告)日：2008-12-25

申请号：US12146918

申请日：2008-06-26

申请人： Yoram Palti ,  Moshe Giladi

发明人： Yoram Palti ,  Moshe Giladi

IPC分类号： A61N1/30 ,  A61N1/04

CPC分类号： A61N1/326 ,  A61N1/40

摘要： Cells that are in the process division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like bacteria, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results can be obtained when the field is sequentially imposed in different directions.

摘要翻译： 处于过程部分的电池容易受到具有特定频率和场强特性的交流电场的损害。 因此，快速分裂细胞的选择性破坏可以通过在目标区域中长时间施加AC电场来实现。 一些应用场地分割的细胞将被破坏，但不分裂的细胞不会受到伤害。 这有选择地损害快速分裂的细胞，如细菌，但不会伤害不分裂的正常细胞。 由于分割单元的脆弱性与分割单元的长轴与电场的力线之间的对准密切相关，所以当场依次施加在不同的方向时，可以获得改进的结果。