公开(公告)号：US20070006113A1

公开(公告)日：2007-01-04

申请号：US11173394

申请日：2005-06-30

Applicant: Bin Hu ,  Vivek Singh ,  Bikram Baidya ,  Kenny Toh ,  Srinivas Bollepalli ,  Yan Borodovsky

Inventor： Bin Hu ,  Vivek Singh ,  Bikram Baidya ,  Kenny Toh ,  Srinivas Bollepalli ,  Yan Borodovsky

IPC: G06F17/50

CPC classification number: G03F1/36

Abstract: A pixelated photolithography mask is optimized for high resolution microelectronic processing. In one embodiment, the invention includes synthesizing a pixelated photolithography mask, applying a pixel flipping function to the mask, comparing the resulting mask to a desired result, and synthesizing an optimized pixelated binary photolithography mask using the function.

Abstract translation: 像素化光刻掩模被优化用于高分辨率微电子处理。 在一个实施例中，本发明包括合成像素化光刻掩模，向掩模施加像素翻转函数，将所得到的掩模与期望的结果进行比较，以及使用该功能合成优化的像素化二值光刻掩模。

公开(公告)号：US6162919A

公开(公告)日：2000-12-19

申请号：US204460

申请日：1998-12-03

Applicant: Mahavir Prashad ,  Bin Hu

Inventor： Mahavir Prashad ,  Bin Hu

IPC: C07D211/34 ,  C07D211/32

CPC classification number: C07D211/34

Abstract: A process for preparing the d-threo isomer of methylphenidate hydrochloride comprising converting d,l-threo methylphenidate hydrochloride to the free base form in a first step, resolving the free base prepared in the first step with (R)-(-)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate to obtain the phosphate salt enriched with the d-threo isomer of methylphenidate in a second step, basifying the phosphate salt to obtain the free base form of the d-threo isomer of methylphenidate in a third step, converting the free base to the hydrochloride salt form of the d-threo isomer of methylphenidate in high optical purity in a fourth step, and recrystallizing the hydrochloride salt form to obtain the desired d-threo isomer in a higher optical purity. An alternative embodiment relates to the preparation of the d-threo isomer of methylphenidate hydrochloride utilizing the hydrochloride salt form of the racemic mixture of threo-methylphenidate directly.

Abstract translation: 一种制备哌甲酯盐酸盐的+ E，未d + EE-同位素异构体的方法，包括在第一步中将+ E，uns d，l + EE-所述哌甲酯盐酸盐转化为游离碱形式， （R） - （ - ） - 1,1'-联萘-2,2'-二基磷酸氢盐的第一步，以获得在第二步中富含哌甲酯的+ E，未d + EE-异构体的磷酸盐 在第三步中碱化磷酸盐以获得哌甲酯的+ E，未d + EE-苏氨酸异构体的游离碱形式，将游离碱转化为+ E，非d + EE-th的盐酸盐形式 在第四步中高哌嗪类异构体的高光学纯度，并重结晶盐酸盐形式，以获得更高的光学纯度的所需的+ E，非d + EE-苏式异构体。 替代实施方案涉及直接用盐酸盐形式的苏氨哌甲酸酯的外消旋混合物制备哌甲酯盐酸盐的+ E，未d + EE-苏氨酸异构体。