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111.发明授权公开(公告)号：US08301253B2
公开(公告)日：2012-10-30
申请号：US13369189
申请日：2012-02-08
申请人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/3684 , A61N1/3627 , A61N1/36514 , A61N1/368
摘要： A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.
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112.发明申请CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 审中-公开基于闭环阻塞的心脏再生治疗系统，装置和方法公开(公告)号：US20120165894A1
公开(公告)日：2012-06-28
申请号：US13405383
申请日：2012-02-27
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译： 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。
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公开(公告)号：US08103326B2
公开(公告)日：2012-01-24
申请号：US12098644
申请日：2008-04-07
IPC分类号： A61B5/00
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译： 描述了通过电阻抗测量来确定患者的血细胞比容的技术。 可植入装置可被配置为利用该技术来评估心脏病人的流体状态。 为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。
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114.发明授权公开(公告)号：US08090442B2
公开(公告)日：2012-01-03
申请号：US11931718
申请日：2007-10-31
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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115.发明授权Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays 有权使用可调节的心房延迟在DDD再同步治疗期间优化卒中量的方法和装置公开(公告)号：US07974695B2
公开(公告)日：2011-07-05
申请号：US11567933
申请日：2006-12-07
申请人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
发明人： Yinghong Yu , Jiang Ding , Julio C. Spinelli , Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译： 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。
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116.发明申请METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效用于设备控制的基因表达用于心脏保护的方法和装置公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。
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公开(公告)号：US20100145401A1
公开(公告)日：2010-06-10
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。
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公开(公告)号：US20100063564A1
公开(公告)日：2010-03-11
申请号：US12620132
申请日：2009-11-17
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36014 , A61N1/37282 , A61N1/37288 , A61N2001/0585
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器和控制器。 神经刺激器适于产生适于在神经靶标处引起交感神经活动的刺激信号。 控制器适于控制神经刺激器以提供物理调理疗法。 该控制器适于控制神经刺激器间歇地在神经靶标上引起交感神经活动。 本文提供了其它方面和实施例。
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119.发明授权公开(公告)号：US07657312B2
公开(公告)日：2010-02-02
申请号：US10700368
申请日：2003-11-03
IPC分类号： A61N1/00 , A61B5/0402
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/3627 , A61N1/368
摘要： A method and device for delivering multi-site ventricular pacing therapy in conjunction with parasympathetic stimulation for reducing ventricular wall stress. Such reduction in ventricular wall stress is useful in reversing or preventing the ventricular remodeling which can occur in heart failure patients.
摘要翻译： 结合副交感神经刺激减少心室壁应力的方法和装置，用于多局部心室起搏治疗。 心室壁应激的这种减少可用于逆转或预防心力衰竭患者发生的心室重塑。
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公开(公告)号：US07647101B2
公开(公告)日：2010-01-12
申请号：US11423249
申请日：2006-06-09
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36014 , A61N1/37282 , A61N1/37288 , A61N2001/0585
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器和控制器。 神经刺激器适于产生适于在神经靶标处引起交感神经活动的刺激信号。 控制器适于控制神经刺激器以提供物理调理疗法。 该控制器适于控制神经刺激器间歇地在神经靶标上引起交感神经活动。 本文提供了其它方面和实施例。
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