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111.发明授权公开(公告)号：US11524080B2
公开(公告)日：2022-12-13
申请号：US17273059
申请日：2019-09-13
IPC: A61K47/69 , A61K47/54 , A61P31/14 , A61P31/04 , A61K9/127 , A61K31/496 , A61K31/513 , A61K31/5383 , A61K31/65 , A61K31/711 , A61K38/21 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/42 , C07K16/10
Abstract: The invention relates to methods for the preparation of a pharmaceutical-vesicle formulation comprising steps of: preparing and processing vesicle components and a pharmaceutical agent to entrap the pharmaceutical agent in the vesicle and form a pharmaceutical-vesicle formulation, wherein the pharmaceutical-vesicle formulation is reconstituted in a known quantity of the pharmaceutical agent dissolved in a pharmaceutically-acceptable carrier to provide a biphasic pharmaceutical-vesicle formulation. The invention also relates to the associated pharmaceutical-vesicle formulations, pharmaceutical kits and uses as a medicament, in particular for the prevention or treatment of infection by bacteria such as Burkholderia pseudomallei and Francisella tularensis, and viruses such as Venezuelan Equine Encephalitis Virus (VEEV).
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公开(公告)号：US20220319022A1
公开(公告)日：2022-10-06
申请号：US17633670
申请日：2020-07-28
Applicant: The Secretary of State for Defence
Inventor： Paul Mason
Abstract: A computer implemented method of decoding a signal. The method includes receiving a signal (which may be an electromagnetic signal), sampling the received signal to generate an input waveform having magnitude and phase components, applying a transform operation to the input waveform to generate a first decoded signal, and outputting the first decoded signal. The transform operation includes pre-processing the input waveform to generate a mirrored inverted waveform and applying a continuous wavelet transform to the mirrored inverted waveform to generate the first decoded signal. This allows inversion of the frequency and temporal resolution of the continuous wavelet transform, thereby enabling improved temporal and frequency decoding of a signal. The method is particularly suitable for signal filters and filtering units.
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公开(公告)号：US20220123844A1
公开(公告)日：2022-04-21
申请号：US17427886
申请日：2020-01-31
Applicant: The Secretary of State for Defence
Inventor： Paul Mason , Stephen John Boyes , Jehan Jayanetti
IPC: H04B17/00 , H04B17/26 , H04B17/318 , H04B17/391
Abstract: A method (10) of regenerating a signal is provided. The method involves sampling (13) a received signal to obtain a plurality of samples each having an associated magnitude. The samples are sorted (15) to obtain a statistical distribution (which may be a histogram). Known distributions are fitted to the statistical distribution using a fitting operation (16, 17), and for each a measure of similarity is obtained. A matched distribution is then determined from the measures of similarity (18), that is subsequently used to regenerate a signal (12) that itself is statistically representative of the originally sampled signal. Such a method mitigates the storage burden associated with the recording and subsequent regeneration of representative wireless signal environments for wireless device testing. Also relates to an apparatus for the same.
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公开(公告)号：US20220120535A1
公开(公告)日：2022-04-21
申请号：US17427901
申请日：2020-02-21
Applicant: The Secretary of State for Defence
Inventor： Peter Rushforth
Abstract: A projectile (601) for piercing a casing of a mine containing an explosive material, comprising a projectile body having a nose portion (603) and a tail portion (604) and a longitudinal axis, a switch, and electrodes (605, 606) separated such that in use an electrical discharge can flow between them through an explosive material contained within a mine, or to initiate an energetic material comprised between the electrodes to detonate an explosive material contained within a mine. Also provided is a method of mine disposal.
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公开(公告)号：US20220113121A1
公开(公告)日：2022-04-14
申请号：US17309914
申请日：2019-11-27
Applicant: The Secretary of State for Defence
Inventor： Samuel Brendan Dixon Cooke
Abstract: A captive piston projectile (40) comprising a payload housing (43), a piston assembly attached to the payload housing (43), and actuation means (46) for urging the piston assembly from a stowed configuration to an extended configuration. The piston assembly comprises a tubular piston member (41) attached around the periphery of the payload housing (43), the attachment optionally being in the form of a circumferential groove (42) within which the piston member (41) can slide. This provides increased thrust whilst maintaining payload volume. Particularly suited to use with barrelled weapons, and also relates to a method of manufacture.
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Patent Agency Ranking
公开(公告)号：US11293285B2
公开(公告)日：2022-04-05
申请号：US16341170
申请日：2017-10-18
Applicant: THE SECRETARY OF STATE FOR DEFENCE
Inventor： Duncan Godfrey Mervyn Thompson
Abstract: The present invention relates to a sealing system, its uses and method of use for forming a seal against a surface, and in particular for plugging and sealing an orifice such as a road or railway tunnel to prevent or minimise the dispersion of hazardous agent(s) in an emergency scenario. The system comprises a frame (200) which can be orientated against a surface (50) of an orifice, frame (10) comprising a perimeter outer surface (180) through which pliant elements (40) can extrude, via apertures (22), following the initiation of a means (30) for providing an overpressure.
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公开(公告)号：US20210388443A1
公开(公告)日：2021-12-16
申请号：US17290931
申请日：2019-11-04
Inventor： Kai Wang , Taek-Kyun Kim , Minyoung Lee , Kathie Walters , Roman Anton Lukaszewski
IPC: C12Q1/6883
Abstract: Methods for diagnosing and/or predicting presence of sepsis in a subject using a gene signature of three or more genes are provided. Also provided are sets containing specific binding molecules for each of the three or more genes, and kits containing such sets.
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118.发明申请公开(公告)号：US20210316009A1
公开(公告)日：2021-10-14
申请号：US17273059
申请日：2019-09-13
IPC: A61K47/69 , A61K9/127 , A61K47/14 , A61K47/28 , A61K47/24 , A61K47/42 , A61K47/26 , A61K31/65 , A61K31/5383 , A61K31/496 , A61K38/21 , A61K31/513 , A61K31/711 , C07K16/10 , A61P31/14 , A61P31/04 , A61K47/54
Abstract: The invention relates to methods for the preparation of a pharmaceutical-vesicle formulation comprising steps of: preparing and processing vesicle components and a pharmaceutical agent to entrap the pharmaceutical agent in the vesicle and form a pharmaceutical-vesicle formulation, wherein the pharmaceutical-vesicle formulation is reconstituted in a known quantity of the pharmaceutical agent dissolved in a pharmaceutically-acceptable carrier to provide a biphasic pharmaceutical-vesicle formulation. The invention also relates to the associated pharmaceutical-vesicle formulations, pharmaceutical kits and uses as a medicament, in particular for the prevention or treatment of infection by bacteria such as Burkholderia pseudomallei and Francisella tularensis, and viruses such as Venezuelan Equine Encephalitis Virus (VEEV).
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119.发明申请公开(公告)号：US20210292827A1
公开(公告)日：2021-09-23
申请号：US17250733
申请日：2019-09-06
Applicant: THE SECRETARY OF STATE FOR DEFENCE
Inventor： CARL NICHOLAS MAYERS
IPC: C12Q1/6848 , C12Q1/6806 , C07H21/04
Abstract: The present invention provides a synthetic nucleic acid for use in methods for interrogating samples suspected of comprising trace DNA. The present invention is especially concerned with forensic analysis of trace DNA, and especially methods and products for achieving collection, extraction and amplification of trace DNA samples capable of limiting the loss of the trace DNA, whilst improving the amplification and the subsequent likelihood of achieving positive sequencing of the trace DNA.
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公开(公告)号：US20210199412A1
公开(公告)日：2021-07-01
申请号：US17055162
申请日：2019-05-22
Applicant: THE SECRETARY OF STATE FOR DEFENCE
Inventor： Ross COLBOURNE
Abstract: An electronic stun grenade (10) comprising a casing (11) and a means for generating light (13), wherein the means for generating light (13) is mounted onto an exterior surface of the casing (11). This allows the interior volume defined by the casing (11) to be more effectively used for containing a means for powering the means for generating light (13). Particularly suited to applications requiring compact stun grenades, such as man portable or weapon launched devices.
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