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    MYOCARDIUM IMAGE ANALYSIS METHOD AND DEVICE
    111.
    发明申请
    MYOCARDIUM IMAGE ANALYSIS METHOD AND DEVICE 有权

    公开(公告)号：US20220012532A1

    公开(公告)日：2022-01-13

    申请号：US17293638

    申请日：2019-11-07

    Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

    Inventor： Dong Hyun YANG ,  June Goo LEE ,  Young-Hak KIM

    IPC: G06K9/62 ,  G06N3/04

    Abstract: A myocardium image analysis method comprising acquiring a target image including precontrast-enhanced myocardium, based on a type of coronary artery related to the myocardium, distinguishing the myocardium included in the target image, using an artificial neural network, providing information on the distinguished myocardium, wherein the artificial neural network is trained based on a training database generated by matching images for training of precontrast-enhanced coronary artery and myocardium and images for training of postcontrast-enhanced coronary artery and myocardium.

    MEDICAL SELF-EXPANDABLE STENT
    114.
    发明申请
    MEDICAL SELF-EXPANDABLE STENT 有权

    公开(公告)号：US20210038363A1

    公开(公告)日：2021-02-11

    申请号：US17080979

    申请日：2020-10-27

    Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

    Inventor： Do Hyun PARK

    IPC: A61F2/04 ,  A61F2/82 ,  A61B18/18

    Abstract: Provided is a medical self-expandable stent which includes a stent body that is self-stretched or expanded by heat and emits the heat, a stretchable light emitting diode (LED) that is stacked to be longitudinally spread on the stent body and emits the heat by converting electric energy into optical energy, and a thin-film formation part that includes a thin film to fix the stretchable LED to the stent body, and is self-expanded by the heat.

    FLUORESCENCE ENDOSCOPIC METHOD FOR VISUALIZATION OF COLORECTAL TISSUE USING FLUOROQUINOLONE ANTIBIOTICS AND METHOD FOR DIAGNOSIS OF LESIONS OF COLORECTAL TISSUE USING THE SAME
    116.
    发明申请
    FLUORESCENCE ENDOSCOPIC METHOD FOR VISUALIZATION OF COLORECTAL TISSUE USING FLUOROQUINOLONE ANTIBIOTICS AND METHOD FOR DIAGNOSIS OF LESIONS OF COLORECTAL TISSUE USING THE SAME 审中-公开

    公开(公告)号：US20200275829A1

    公开(公告)日：2020-09-03

    申请号：US16289555

    申请日：2019-02-28

    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  OSONG MEDICAL INNOVATION FOUNDATION

    Inventor： Seong Han KIM ,  Seunghun LEE ,  Hoon Cheol JANG ,  Bumju KIM ,  Viet Hoan LE ,  Wonyeong PARK ,  Ki Hean KIM ,  Seung Jae MYUNG ,  Seungrag LEE

    IPC: A61B1/04 ,  A61B5/00 ,  A61K31/496

    Abstract: A fluorescence endoscopic method for visualization of colorectal tissue using a fluoroquinolone antibiotic and a method for diagnosis of lesions of colorectal tissue using the same. The fluorescence endoscopic method for visualization of colorectal tissue includes staining goblet cells of the colorectal tissue with moxifloxacin, which is a fluoroquinolone antibiotic, and exciting the stained goblet cells with single photons in the near UV region or in the visible region, followed by fluorescence endoscopic photographing of the goblet cells, thereby enabling acquisition of morphological information on living tissue without damage to or destruction of the colorectal tissue, while allowing diagnosis of lesions of the colon based on the morphological information on living tissue such as information on the distribution of the goblet cells. Specifically, the fluorescence endoscopic method includes: a colorectal tissue staining step in which the crypt of the colorectal tissue is stained with a fluoroquinolone antibiotic; an image pickup unit insertion step in which an image pickup unit is inserted into the colon; a light irradiation step in which the colorectal tissue is irradiated with excitation light from a light source of the image pickup unit; a colorectal tissue photographing step in which the colorectal tissue is photographed using a photographing device of the image pickup unit through the fluoroquinolone antibiotic fluorescence-excited by light in the light irradiation step, wherein, in the colorectal tissue staining step, goblet cells of the crypt are stained with the fluoroquinolone antibiotic; in the light irradiation step, the light source emits single photons as excitation light inducing fluorescence of the fluoroquinolone antibiotic, the excitation light from the light source having a wavelength band within the near UV and visible regions; and, in the image pickup unit insertion step, the image pickup unit is a general fluorescence endoscope or a confocal endoscopic microscope.

    NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT, AND USE THEREOF
    120.
    发明申请
    NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT, AND USE THEREOF 审中-公开

    公开(公告)号：US20190127802A1

    公开(公告)日：2019-05-02

    申请号：US15329942

    申请日：2015-07-29

    Applicant: THE ASAN FOUNDATION

    Inventor： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee Moon ,  Jae Sik Shin ,  Seung Mi Kim ,  Dae Hee Lee ,  Eun Young Lee ,  Seul Lee ,  Yong Sang Hong

    IPC: C12Q1/6886 ,  A61P35/00 ,  A61P43/00

    Abstract: The present disclosure relates to a new biomarker for predicting susceptibility to an EGFR-targeted agent and a use thereof, and more particularly, provides a biomarker for predicting susceptibility to an EGFR (Epidermal Growth Factor Receptor)-targeted agent, comprising a RON (Recepteur d'Origine Nantais) gene; a composition for predicting susceptibility to the EGFR-targeted agent, comprising an agent which measures a gene expression level of the biomarker; or an expression or activity level of a protein thereof; a composition for enhancing the susceptibility to the EGFR-targeted agent, comprising an inhibitor of the expression of the gene or the expression or activity of the protein of the gene as active ingredients; a kit for predicting the susceptibility to the EGFR-targeted agent, comprising the composition; and a method for predicting the susceptibility to the EGFR-targeted agent. According to the present disclosure, since an effect of predicting the susceptibility to the EGFR-targeted agent is excellent in a colon cancer, the present disclosure may be useful in the treatment of the colon cancer.

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