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公开(公告)号：US12211203B2
公开(公告)日：2025-01-28
申请号：US17633113
申请日：2020-08-05
Inventor： Soo Jin Kang , Hyun Seok Min
Abstract: The disclosure purposes to provide an optical coherence tomography (OCT)-based system for diagnosing a high risk lesion such as a vulnerable atheromatous plaque by using an artificial intelligence model through deep learning. A deep learning-based diagnostic method of diagnosing a high risk lesion of a coronary artery includes: acquiring an OCT image of a coronary artery lesion of a patient; extracting a first feature of a thin cap from the OCT image; setting a region of interest included in the OCT image on a basis of the first feature; and determining whether the region of interest includes a high risk lesion.
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公开(公告)号：US20240369412A1
公开(公告)日：2024-11-07
申请号：US18557769
申请日：2022-04-28
Inventor： Sang Yeob KIM , Chan Gi PACK
Abstract: A method of quantifying fluorescent dyes labeled on extracellular vesicles, including providing an extracellular vesicle molecule labeled with a fluorescence dye molecule, and determining a brightness of each of the extracellular vesicle molecule labeled with the fluorescence dye molecule and the fluorescence dye molecule through fluorescence correlation spectroscopy (FCS) of the extracellular vesicle molecule and the fluorescence dye molecule.
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公开(公告)号：US12070487B2
公开(公告)日：2024-08-27
申请号：US17418684
申请日：2019-12-24
Inventor： You Sook Cho , Jun Pyo Choi , In Jeoung Baek , Hyouk Soo Kwon , So Young Park
CPC classification number: A61K38/1709 , A61K45/06 , A61P11/06
Abstract: The present invention relates to a pharmaceutical composition comprising a progesterone-induced blocking factor (PIBF) protein as an active ingredient for prevention or treatment of inflammatory disease. In the present invention, menopausal asthma animal models have been experimentally identified to decrease airway inflammation when treated with PIBF protein. Thus, the composition can be advantageously used in postmenopausal female asthma patients.
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公开(公告)号：US20240115614A1
公开(公告)日：2024-04-11
申请号：US18262341
申请日：2022-01-14
Inventor： Hun Sik KIM , Seong Who KIM , Eunbi YI , Hyojeong KIM , Jung Min KIM , Woo Seon CHOI
IPC: A61K35/28 , A61P37/06 , C07K14/705 , C12N5/0775 , C12N15/86
CPC classification number: A61K35/28 , A61P37/06 , C07K14/70503 , C12N5/0662 , C12N15/86 , C12N2740/15043
Abstract: A method for treating a cell damage-related disease, including administering a composition to a subject in need thereof. The composition contains, as an active ingredient, one or more selected from the group consisting of stem cells genetically engineered to overexpress a carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family protein, cells differentiated from the stem cells, and components derived from the stem cells.
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公开(公告)号：US20240082305A1
公开(公告)日：2024-03-14
申请号：US18262303
申请日：2022-01-20
Applicant: Seoul National University R&DB Foundation , Seoul National University Hospital , The Asan Foundation
Inventor： Jaeseok YANG , Sun-Kyung LEE , Joon Young JANG , Junho CHUNG , Jerome HAN , Nara SHIN , Hyori KIM
IPC: A61K35/17 , A61K39/00 , A61P37/06 , C07K16/28 , C12N5/0783
CPC classification number: A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/46433 , A61P37/06 , C07K16/2833 , C12N5/0637 , A61K2239/13 , A61K2239/17 , A61K2239/21
Abstract: Antibody-mediated rejection (ABMR) is one of the main obstacles to successful transplantation, including ABO blood group-incompatible (ABOi) transplantation. C4d deposition is a marker of ABMR and is also found in most ABOi allograft tissues. Described herein are anti-C4d CAR Tregs that suppress ABMR in ABOi allografts. Anti-C4d CAR Tregs prepared by retroviral transduction of CAR into CD62L +CD4 +CD25 +Tregs, expressed Foxp3, CD25, CTLA-4, LAP, and GITR to similar extents as non-transduced Tregs. Anti-C4d CAR Tregs were activated by specific binding to C4d and suppressed in vitro T cell proliferation as well as non-transduced Tregs. Furthermore, adoptive transfer of anti-C4d CAR Tregs significantly prolonged mouse ABOi heart allograft survival (P
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Patent Agency Ranking
公开(公告)号：US11877880B2
公开(公告)日：2024-01-23
申请号：US17293563
申请日：2019-11-07
Inventor： Dong Hyun Yang , June Goo Lee , Young-Hak Kim
CPC classification number: A61B6/503 , A61B6/481 , A61B6/504 , A61B6/5217 , G06T7/0012 , G16H50/20 , G16H50/30 , G06T2207/10081 , G06T2207/30048 , G06T2207/30101
Abstract: A method for calculating a coronary artery calcium score, the method comprising acquiring a target image for a coronary artery and myocardium before contrast enhancement, identifying the coronary artery included in the target image by using an artificial neural network, calculating a coronary artery calcium score based on the identified coronary artery, wherein the artificial neural network is trained based on a training database generated via alignment between a pre-acquired image of a coronary artery and myocardium before contrast enhancement and a pre-acquired image of a coronary artery and myocardium after contrast enhancement.
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7.发明公开公开(公告)号：US20230321160A1
公开(公告)日：2023-10-12
申请号：US17998537
申请日：2021-05-07
Inventor： Mi-Na KWEON , Seungil KIM
IPC: A61K35/741 , A61P1/04 , C12N1/20
CPC classification number: A61K35/741 , A61P1/04 , C12N1/205 , C12R2001/01
Abstract: An Akkermansia muciniphila AK32 (Accession No. KCTC 14172BP) strain. The Akkermansia muciniphila AK32 strain prevents or improves intestinal damage. A method for preventing, improving or treating intestinal damage, including administering to a subject an effective amount of the Akkermansia muciniphila AK32 strain or a culture thereof as an active ingredient.
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公开(公告)号：US20230265174A1
公开(公告)日：2023-08-24
申请号：US18004029
申请日：2021-06-18
Inventor： Su Hwan CHANG , Song-Cheol KIM , Yeon Sook CHOI , Hyo Ri KIM
CPC classification number: C07K16/18 , A61P35/04 , C07K2317/565 , C07K2317/24
Abstract: An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein (LGALS3BP), and a use thereof, is described. The antibody or antigen-binding fragment thereof may comprise heavy chain CDRs and light chain CDRs of specific sequences. The antibody specifically binding to LGALS3BP has been found to inhibit cancer growth and metastasis in an animal model with cancer and may be effective for alleviating or treating cancer.
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9.发明公开公开(公告)号：US20230258954A1
公开(公告)日：2023-08-17
申请号：US18306309
申请日：2023-04-25
Inventor： Jun Ki KIM , Bjorn Rolf PAULSON , Bohlooli Darian SAEED
IPC: G02B27/64
CPC classification number: G02B27/644 , G02B23/2476
Abstract: Disclosed is a suction type stabilizer for a lens including a probe mount, in which a lens is disposed in an interior thereof and an opening that contacts a specimen is formed on one side thereof, an elastic body interposed between the lens and the probe mount, that elastically supports the lens, and defining a division space between the lens and the opening, and a negative pressure forming part forming a negative pressure while suctioning air accommodated in the division space and attaching and fixing the specimen to the opening.
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公开(公告)号：US20230181307A1
公开(公告)日：2023-06-15
申请号：US18166764
申请日：2023-02-09
Inventor： Jae Yong JEON , Hwayeong CHEON , Jung Hoon PARK
IPC: A61F2/07
CPC classification number: A61F2/07 , A61F2002/072 , A61F2220/0025 , A61F2220/005 , A61F2210/00
Abstract: Disclosed is a graft for a biological tube including a graft having a hollow of a specific length, having openings at opposite ends along a lengthwise direction thereof, and being contractible, and the graft is contracted to be adhered to outer peripheral surfaces of biological tubes when heat is applied to the graft in a state, in which portions of the biological tubes are inserted into the openings of the graft.
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