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公开(公告)号：US12070487B2
公开(公告)日：2024-08-27
申请号：US17418684
申请日：2019-12-24
发明人： You Sook Cho , Jun Pyo Choi , In Jeoung Baek , Hyouk Soo Kwon , So Young Park
CPC分类号： A61K38/1709 , A61K45/06 , A61P11/06
摘要： The present invention relates to a pharmaceutical composition comprising a progesterone-induced blocking factor (PIBF) protein as an active ingredient for prevention or treatment of inflammatory disease. In the present invention, menopausal asthma animal models have been experimentally identified to decrease airway inflammation when treated with PIBF protein. Thus, the composition can be advantageously used in postmenopausal female asthma patients.
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公开(公告)号：US20240115614A1
公开(公告)日：2024-04-11
申请号：US18262341
申请日：2022-01-14
发明人： Hun Sik KIM , Seong Who KIM , Eunbi YI , Hyojeong KIM , Jung Min KIM , Woo Seon CHOI
IPC分类号： A61K35/28 , A61P37/06 , C07K14/705 , C12N5/0775 , C12N15/86
CPC分类号： A61K35/28 , A61P37/06 , C07K14/70503 , C12N5/0662 , C12N15/86 , C12N2740/15043
摘要： A method for treating a cell damage-related disease, including administering a composition to a subject in need thereof. The composition contains, as an active ingredient, one or more selected from the group consisting of stem cells genetically engineered to overexpress a carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family protein, cells differentiated from the stem cells, and components derived from the stem cells.
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公开(公告)号：US20240082305A1
公开(公告)日：2024-03-14
申请号：US18262303
申请日：2022-01-20
申请人： Seoul National University R&DB Foundation , Seoul National University Hospital , The Asan Foundation
发明人： Jaeseok YANG , Sun-Kyung LEE , Joon Young JANG , Junho CHUNG , Jerome HAN , Nara SHIN , Hyori KIM
IPC分类号： A61K35/17 , A61K39/00 , A61P37/06 , C07K16/28 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/46433 , A61P37/06 , C07K16/2833 , C12N5/0637 , A61K2239/13 , A61K2239/17 , A61K2239/21
摘要： Antibody-mediated rejection (ABMR) is one of the main obstacles to successful transplantation, including ABO blood group-incompatible (ABOi) transplantation. C4d deposition is a marker of ABMR and is also found in most ABOi allograft tissues. Described herein are anti-C4d CAR Tregs that suppress ABMR in ABOi allografts. Anti-C4d CAR Tregs prepared by retroviral transduction of CAR into CD62L +CD4 +CD25 +Tregs, expressed Foxp3, CD25, CTLA-4, LAP, and GITR to similar extents as non-transduced Tregs. Anti-C4d CAR Tregs were activated by specific binding to C4d and suppressed in vitro T cell proliferation as well as non-transduced Tregs. Furthermore, adoptive transfer of anti-C4d CAR Tregs significantly prolonged mouse ABOi heart allograft survival (P
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公开(公告)号：US11877880B2
公开(公告)日：2024-01-23
申请号：US17293563
申请日：2019-11-07
发明人： Dong Hyun Yang , June Goo Lee , Young-Hak Kim
CPC分类号： A61B6/503 , A61B6/481 , A61B6/504 , A61B6/5217 , G06T7/0012 , G16H50/20 , G16H50/30 , G06T2207/10081 , G06T2207/30048 , G06T2207/30101
摘要： A method for calculating a coronary artery calcium score, the method comprising acquiring a target image for a coronary artery and myocardium before contrast enhancement, identifying the coronary artery included in the target image by using an artificial neural network, calculating a coronary artery calcium score based on the identified coronary artery, wherein the artificial neural network is trained based on a training database generated via alignment between a pre-acquired image of a coronary artery and myocardium before contrast enhancement and a pre-acquired image of a coronary artery and myocardium after contrast enhancement.
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5.发明公开公开(公告)号：US20230321160A1
公开(公告)日：2023-10-12
申请号：US17998537
申请日：2021-05-07
发明人： Mi-Na KWEON , Seungil KIM
IPC分类号： A61K35/741 , A61P1/04 , C12N1/20
CPC分类号： A61K35/741 , A61P1/04 , C12N1/205 , C12R2001/01
摘要： An Akkermansia muciniphila AK32 (Accession No. KCTC 14172BP) strain. The Akkermansia muciniphila AK32 strain prevents or improves intestinal damage. A method for preventing, improving or treating intestinal damage, including administering to a subject an effective amount of the Akkermansia muciniphila AK32 strain or a culture thereof as an active ingredient.
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公开(公告)号：US20230265174A1
公开(公告)日：2023-08-24
申请号：US18004029
申请日：2021-06-18
发明人： Su Hwan CHANG , Song-Cheol KIM , Yeon Sook CHOI , Hyo Ri KIM
CPC分类号： C07K16/18 , A61P35/04 , C07K2317/565 , C07K2317/24
摘要： An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein (LGALS3BP), and a use thereof, is described. The antibody or antigen-binding fragment thereof may comprise heavy chain CDRs and light chain CDRs of specific sequences. The antibody specifically binding to LGALS3BP has been found to inhibit cancer growth and metastasis in an animal model with cancer and may be effective for alleviating or treating cancer.
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7.发明公开公开(公告)号：US20230258954A1
公开(公告)日：2023-08-17
申请号：US18306309
申请日：2023-04-25
IPC分类号： G02B27/64
CPC分类号： G02B27/644 , G02B23/2476
摘要： Disclosed is a suction type stabilizer for a lens including a probe mount, in which a lens is disposed in an interior thereof and an opening that contacts a specimen is formed on one side thereof, an elastic body interposed between the lens and the probe mount, that elastically supports the lens, and defining a division space between the lens and the opening, and a negative pressure forming part forming a negative pressure while suctioning air accommodated in the division space and attaching and fixing the specimen to the opening.
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公开(公告)号：US20230181307A1
公开(公告)日：2023-06-15
申请号：US18166764
申请日：2023-02-09
发明人： Jae Yong JEON , Hwayeong CHEON , Jung Hoon PARK
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2002/072 , A61F2220/0025 , A61F2220/005 , A61F2210/00
摘要： Disclosed is a graft for a biological tube including a graft having a hollow of a specific length, having openings at opposite ends along a lengthwise direction thereof, and being contractible, and the graft is contracted to be adhered to outer peripheral surfaces of biological tubes when heat is applied to the graft in a state, in which portions of the biological tubes are inserted into the openings of the graft.
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公开(公告)号：US20230017150A1
公开(公告)日：2023-01-19
申请号：US17812892
申请日：2022-07-15
发明人： Deok Hee LEE , Seon Moon HWANG , Joon Ho CHOI
IPC分类号： A61B17/12
摘要： A hydrogel stent for cerebral aneurysm includes a hydrogel polymer, and a stent body wrapping at least a portion of the hydrogel polymer. The stent body is expandable in a cerebral aneurysm of a blood vessel. The stent body is provided in a mesh type surrounding at least a portion of the hydrogel polymers. An embolization device for cerebral aneurysm, includes a hydrogel stent for cerebral aneurysm; a micro-conduit providing a movement path for guiding the hydrogel stent to a cerebral aneurysm of a blood vessel; and a pusher wire connected to the hydrogel stent to be movable in the movement path.
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公开(公告)号：US11452794B2
公开(公告)日：2022-09-27
申请号：US15772213
申请日：2016-10-28
发明人： Hee Jun Park , Hyun Seung Ryu , Joon Pio Hong , Jun Hyuk Seo , Jong Ha Park , Soon Gee Hong , Hak Su Jang , So Myoung Lee , Bo Young Yoo
摘要： The present invention relates to a wound dressing material comprising a fibrillated acellular dermis matrix and a biodegradable polymer aqueous solution and, more specifically, to: a wound dressing material comprising 5-20 wt % of a fibrillated acellular dermis matrix, 0.5-5 wt % of a biodegradable polymer, and 75-94.5 wt % of water; and a preparation method therefor.
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