公开(公告)号：US20050142583A1

公开(公告)日：2005-06-30

申请号：US10949163

申请日：2004-09-24

Applicant: David Liu ,  Zev Gartner ,  Matthew Kanan

Inventor： David Liu ,  Zev Gartner ,  Matthew Kanan

IPC: C12N15/09 ,  C07B61/00 ,  C08G85/00 ,  C12N15/10 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543

CPC classification number: C12N15/1068 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00

Abstract: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.

Abstract translation: 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 本发明提供了基于核酸模板合成，选择，扩增和演化非天然分子的方法，组合物和系统。 核酸模板的序列用于引导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可以被扩增和/或进化以产生用于重新筛选的相同分子或相关分子。 本发明的本发明的方法和组合物以与天然生物聚合物如多核苷酸和蛋白质的扩增类似的方式允许非天然分子的扩增和进化。

公开(公告)号：US20050070016A1

公开(公告)日：2005-03-31

申请号：US10852626

申请日：2004-05-24

Applicant: David Liu ,  Allen Buskirk ,  Polina Kehayova

Inventor： David Liu ,  Allen Buskirk ,  Polina Kehayova

IPC: C07H21/02 ,  C12N20060101 ,  C12N15/10 ,  C12N15/115 ,  C12N15/63 ,  C12N15/80 ,  C12N15/81 ,  C12N15/85

CPC classification number: C12N15/1086 ,  C12N15/1048 ,  C12N15/115 ,  C12N15/63 ,  C12N2310/16 ,  C12N2310/18 ,  C12N2310/321 ,  C12N2320/13 ,  C12N2330/31

Abstract: RNA molecules have been shown to play a variety of functional roles in biological processes. RNA sequences can adopt 3-D conformations able to regulate transcription. RNA-based transcriptional regulators when recruited to a DNA template act to promote or suppress the transcription of nearby genes. The regulators are thought to act by mimicing the activation domains of protein transcriptional activators. These RNA-based transcriptional regulators may be engineered to regulate transcription based on the binding of a ligand such as a small molecule. RNA sequences of the regulators may be evolved to produce regulators with a greater degree of transcriptional activation or suppression. The RNA-based system of the present invention is useful in studying biological processes and in altering biological process in a therapeutic context.

Abstract translation: 已经显示RNA分子在生物过程中起多种功能作用。 RNA序列可以采用能够调节转录的3-D构象。 当募集到DNA模板时，基于RNA的转录调节子用于促进或抑制附近基因的转录。 认为调节剂通过模拟蛋白质转录激活子的激活结构域来起作用。 这些基于RNA的转录调节子可以被工程化以基于诸如小分子的配体的结合来调节转录。 调节剂的RNA序列可以进化以产生具有更大程度的转录激活或抑制的调节物。 本发明的基于RNA的系统可用于研究生物过程和在治疗情境中改变生物过程。

公开(公告)号：US20050042669A1

公开(公告)日：2005-02-24

申请号：US10949162

申请日：2004-09-24

Applicant: David Liu ,  Zev Gartner ,  Matthew Kanan

Inventor： David Liu ,  Zev Gartner ,  Matthew Kanan

IPC: C12N15/09 ,  C07B61/00 ,  C08G85/00 ,  C12N15/10 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00 ,  C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/543

CPC classification number: C12N15/1068 ,  C12P1/00 ,  C12P19/34 ,  C12P21/00

Abstract: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.

公开(公告)号：USD475796S1

公开(公告)日：2003-06-10

申请号：US29161228

申请日：2002-05-28

Applicant: David Liu

Designer： David Liu

公开(公告)号：US06461129B2

公开(公告)日：2002-10-08

申请号：US09791515

申请日：2001-02-23

Applicant: David Liu

Inventor： David Liu

IPC: F03C200

CPC classification number: F01C21/102 ,  F04C18/0253 ,  F04C2230/603 ,  F05C2201/0442 ,  F05C2251/046

Abstract: A scroll type apparatus for fluid displacement is disclosed. In one embodiment, the apparatus includes an adjustment mechanism capable of being adjusted after assembly of the apparatus to close an axial gap between scroll members and account for manufacturing tolerances in apparatus components. In another embodiment, the apparatus includes an orbital scroll of two portions, with a supporting portion surrounding an eccentric bearing of higher density than that of a scroll portion. The center of mass of the orbital scroll is thus moved towards the eccentric bearing to reduce torquing of the scroll as it orbits. In a further embodiment, the apparatus includes an orbital scroll having two portions, a supporting portion surrounding an eccentric bearing having a lower coefficient of thermal expansion than that of a scroll portion, to reduce thermal expansion of the supporting portion, reducing misaligmnent of the eccentric orbital scroll on the bearing.

Abstract translation: 公开了一种用于流体排放的涡旋式装置。 在一个实施例中，该装置包括调节机构，该调节机构能够在组装装置之后进行调整，以封闭涡旋构件之间的轴向间隙并考虑到设备部件中的制造公差。 在另一个实施例中，该装置包括两个部分的轨道涡卷，其中一个支承部分围绕一个比涡卷部分密度高的偏心轴承。 因此，轨道涡旋体的质心向着偏心轴承运动，以减小涡卷在其轨道运动时的扭矩。 在另一实施例中，该装置包括具有两部分的轨道涡旋件，围绕偏心轴承的支撑部分，该偏心轴承具有比涡旋部分的热膨胀系数低的热膨胀系数，以减少支撑部分的热膨胀，减少偏心的误差 轴承上的轨道滚动。

公开(公告)号：US06234631B1

公开(公告)日：2001-05-22

申请号：US09521855

申请日：2000-03-09

Applicant: Edwin J. Sarver ,  David Liu

Inventor： Edwin J. Sarver ,  David Liu

IPC: A61B310

CPC classification number: A61B3/1015 ,  A61B3/1005 ,  A61B3/107

Abstract: A method for the simultaneous measurement of the anterior and posterior corneal surfaces, corneal thickness, and optical aberrations of the eye. The method employs direct measurements and ray tracing to provide a wide range of measurements for use by the ophthalmic community.

Abstract translation: 用于同时测量前角膜和后角膜表面，角膜厚度和眼睛光学像差的方法。 该方法采用直接测量和光线跟踪，以提供广泛的测量范围，供眼科社区使用。

公开(公告)号：US06039854A

公开(公告)日：2000-03-21

申请号：US157514

申请日：1998-09-21

Applicant: David Liu

Inventor： David Liu

IPC: C23C14/50 ,  C23C14/58 ,  C23C16/458 ,  H01L21/687

CPC classification number: H01L21/68735 ,  C23C14/50 ,  C23C14/5806 ,  C23C16/4585 ,  H01L21/68757

Abstract: A clamp for fixturing a substrate when forming and thermally processing upon the substrate a thermally flowable layer. The clamp comprises a backing member having a top member connected through a first mechanical means to the backing member. The backing member and the top member are sized such that a substrate may be clamped between the backing member and the top member. A portion of the top member overlaps the substrate and leaves exposed a first portion of the substrate when the substrate is clamped between the backing member and the top member. The clamp also comprises a shroud connected through a second mechanical means to the backing member, where a portion of the shroud overlaps the top member. The shroud leaves exposed a second portion of the substrate which is smaller than and contained within the first portion of the substrate. The shroud is removable from the backing member while the substrate remains clamped between the backing member and the top member.

Abstract translation: 一种夹具，用于在基底上形成热处理热可流动层时对基材进行固定。 夹具包括背衬构件，其具有通过第一机械装置连接到背衬构件的顶部构件。 所述背衬构件和所述顶部构件的尺寸设计成使得衬底可被夹持在所述衬垫构件和所述顶部构件之间。 顶部构件的一部分与衬底重叠，并且当衬底夹在衬垫构件和顶部构件之间时，露出衬底的第一部分。 夹具还包括通过第二机械装置连接到背衬构件的罩，其中护罩的一部分与顶部构件重叠。 护罩露出基板的第二部分，其小于并且包含在基板的第一部分内。 当衬垫保持夹持在背衬构件和顶部构件之间时，护罩可从背衬构件移除。

公开(公告)号：USD407747S

公开(公告)日：1999-04-06

申请号：US55528

申请日：1996-06-06

Applicant: David Liu

Designer： David Liu

公开(公告)号：US5873983A

公开(公告)日：1999-02-23

申请号：US782703

申请日：1997-01-13

Applicant: David Liu

Inventor： David Liu

IPC: C23C14/50 ,  C23C16/458 ,  C23C14/34

CPC classification number: C23C16/4585 ,  C23C14/50

Abstract: A method for forming and thermally processing upon a substrate a low melting temperature metal containing conductor layer. There is first provided a substrate. The substrate is fixtured within a clamp comprised of a backing member and a top member connected through a mechanical means to the backing member. A portion of the top member overlaps the substrate and leaves exposed a first portion of the substrate when the substrate is clamped between the backing member and the top member. There is then formed upon the first portion of the substrate a low melting temperature metal containing conductor layer while simultaneously forming upon the top member of the clamp a low melting temperature metal containing conductor layer residue. Finally, there is processing thermally the low melting temperature metal containing conductor layer and the low melting temperature metal containing conductor layer residue while positioning the substrate and the clamp in a substantially face down position. Through the method, a thermally processed low melting temperature metal containing conductor layer residue formed from the low melting temperature metal containing conductor layer residue will not flow and bridge with a thermally processed low melting temperature metal containing conductor layer formed from the low melting temperature metal containing conductor layer.

Abstract translation: 一种用于在基底上形成和热处理低熔点金属的导体层的方法。 首先提供基板。 衬底固定在夹具内，夹具由背衬构件和通过机械装置连接到衬垫构件的顶部构件组成。 顶部构件的一部分与衬底重叠，并且当衬底夹持在衬垫构件和顶部构件之间时，露出衬底的第一部分。 然后在衬底的第一部分上形成低熔点金属的导体层，同时在夹具的顶部构件上形成含有低熔点金属的导体层残留物。 最后，在将基板和夹具基本面向下的位置定位时，热处理含有低熔点金属的导体层和低熔点金属的导体层残留物。 通过该方法，由含低熔点金属的导体层残留物形成的热处理低熔点含金属的导体层残留物不会流动，并与含有低熔点金属的导电体层 导体层。

公开(公告)号：USD1002594S1

公开(公告)日：2023-10-24

申请号：US29778012

申请日：2021-04-09

Applicant: David Liu

Designer： David Liu

Abstract: FIG. 1 is a left side and front perspective view of my antenna with bowtie sectors;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a left side side view being a mirror image thereof;
FIG. 6 is a top view thereof; and,
FIG. 7 is a bottom view thereof.
The broken lines in the drawings showing portions of the article form no part of the claimed design.