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177 条记录 (耗时 0.038 秒)

    Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones
    112.
    发明授权
    Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones 失效
    取代的3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮

    公开(公告)号：US4680414A

    公开(公告)日：1987-07-14

    申请号：US832488

    申请日：1986-02-20

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D207/44 ,  C07D207/456 ,  C07D409/10 ,  C07D207/40 ,  A61K31/40

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s, for treatment of grey matter edema
    113.
    发明授权
    Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s, for treatment of grey matter edema 失效
    使用取代的3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，用于治疗灰质水肿

    公开(公告)号：US4605663A

    公开(公告)日：1986-08-12

    申请号：US606085

    申请日：1984-05-01

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D207/44 ,  C07D207/456 ,  C07D409/10 ,  A61K31/40

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones
    114.
    发明授权
    Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones 失效
    用3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮处理灰质水肿

    公开(公告)号：US4596821A

    公开(公告)日：1986-06-24

    申请号：US605739

    申请日：1984-05-01

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D207/44 ,  C07D207/456 ,  C07D409/10 ,  A61K31/40

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use
    118.
    发明授权
    1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use 失效
    1-（取代的 - 氨基烷氧基苯基）-2-亚甲基-1-烷酮，组合物和用途

    公开(公告)号：US4390537A

    公开(公告)日：1983-06-28

    申请号：US379604

    申请日：1982-05-19

    申请人： Edward J. Cragoe, Jr.

    发明人： Edward J. Cragoe, Jr.

    IPC分类号： C07D295/092 ,  C07D295/10 ,  A61K31/535

    CPC分类号： C07D295/088

    摘要： 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, converting the ether formed to a salt of Mannich base by reacting it with a salt of a secondary amine in the presence of formaldehyde or paraformaldehyde and treating the Mannich salt with a weak base to deaminate the same and form the final product.

    摘要翻译： 1-（取代的 - 氨基烷氧基苯基）-2-亚甲基-1-烷基酮，一类具有抗过敏性质的化合物，用于治疗过敏性病症，例如通过用氨基烷基卤化物醚化烷酰基苯酚制备的哮喘，将醚 通过在甲醛或多聚甲醛的存在下与仲胺的盐反应形成曼尼希碱的盐，并用弱碱处理曼尼希盐以使其脱氨，形成最终产物。

    1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use thereof
    119.
    发明授权
    1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use thereof 失效
    1-（取代的 - 氨基烷氧基苯基）-2-亚甲基-1-烷基酮，其组合物和用途

    公开(公告)号：US4342782A

    公开(公告)日：1982-08-03

    申请号：US961422

    申请日：1978-11-16

    申请人： Edward J. Cragoe, Jr.

    发明人： Edward J. Cragoe, Jr.

    IPC分类号： C07D295/092 ,  A61K31/135 ,  C07C97/10

    CPC分类号： C07D295/088 ,  Y10S514/826

    摘要： 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing antiallergic propertiesfor use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, converting the ether formed to a salt of Mannich base by reacting it with a salt of a secondary amine in the presence of formaldehyde or paraformaldehyde and treating the Mannich salt with a weak base todeaminate the same and form the final product.

    摘要翻译： 1-（取代的 - 氨基烷氧基苯基）-2-亚甲基-1-烷基酮，一类具有抗过敏性质的化合物，用于治疗过敏性疾病，例如通过用氨基烷基卤化物醚化烷酰基苯酚制备的哮喘，将形成的醚转化为 通过在甲醛或多聚甲醛的存在下与仲胺的盐反应，并用弱碱处理曼尼希盐以使其破坏并形成最终产物，使曼尼希碱的盐反应。