Patent search cpc:"C07D277/26" Page 1

1.

发明授权
Compositions and methods for inhibiting group II intron RNA 有权

公开(公告)号：US11739104B2

公开(公告)日：2023-08-29

申请号：US16964621

申请日：2019-01-25

Applicant: YALE UNIVERSITY

Inventor： Anna Pyle , Olga Fedorova , Erik Gunnar Jagdmann , Michael Van Zandt , Lin Yuan , Albert DeBerardinis

IPC: C07D307/80 , C07F5/02 , A61P31/10 , C07C49/84 , C07C233/65 , C07C233/73 , C07C243/38 , C07D207/08 , C07D211/16 , C07D217/04 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/26 , C07D277/66 , C07D295/192 , C07D295/215 , C07D307/52 , C07D307/83 , C07D405/04 , C07D405/12 , C07D413/04

CPC classification number: C07F5/027 , A61P31/10 , C07C49/84 , C07C233/65 , C07C233/73 , C07C243/38 , C07D207/08 , C07D211/16 , C07D217/04 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/26 , C07D277/66 , C07D295/192 , C07D295/215 , C07D307/52 , C07D307/80 , C07D307/83 , C07D405/04 , C07D405/12 , C07D413/04

Abstract: The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron. The present invention also provides compositions and methods for inhibiting group II intron splicing for inhibiting, preventing or reducing growth of an organism harboring an active group II intron.

2.

发明授权
Photo-decomposable compound, photoresist composition including the same, and method of manufacturing integrated circuit device 有权

公开(公告)号：US11662662B2

公开(公告)日：2023-05-30

申请号：US16994957

申请日：2020-08-17

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Hyunji Song , Sukkoo Hong , Sumin Kim , Yechan Kim , Juyoung Kim , Jinjoo Kim , Hyunwoo Kim , Juhyeon Park , Songse Yi

IPC: G03F7/004 , G03F7/039 , C07D213/68 , C07D263/32 , C07D233/64 , C07D277/26

CPC classification number: G03F7/0045 , C07D213/68 , C07D233/64 , C07D263/32 , C07D277/26 , G03F7/0392

Abstract: A photo-decomposable compound, a photoresist composition, and a method of manufacturing an IC device, the compound generating acid upon exposure and acts as a quenching base that neutralizes acid in an unexposed state and being represented by Formula 1:

wherein, in Formula 1, Ra is a C5 to C40 substituted or unsubstituted cyclic hydrocarbon group including at least one nitrogen atom, Ya is a C1 to C20 divalent linear or cyclic hydrocarbon group, n is an integer of 1 to 5, and A+ is a counter ion.

3.

发明申请
Methylamine Derivatives as Lysysl Oxidase Inhibitors for the Treatment of Cancer 审中-公开

公开(公告)号：US20190152966A1

公开(公告)日：2019-05-23

申请号：US15999458

申请日：2017-02-17

Applicant: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

Inventor： Caroline SPRINGER , Richard MARAIS , Dan NICULES-CU-DUVAZ , Leo LEUNG , Deborah SMITHEN , Cedric CALLENS , Haoran TANG

IPC: C07D417/12 , A61P35/00 , C07D333/18 , C07D277/26 , C12Q1/37

CPC classification number: C07D417/12 , A61P35/00 , C07D263/46 , C07D277/26 , C07D277/36 , C07D333/18 , C07D333/34 , C07D409/12 , C12Q1/37 , C12Y304/21

Abstract: Provided are compounds of the Formula (I), or a pharmaceutically acceptable salt thereof: wherein W, X, Y, Z, x, R1, R2, R3, x and n are defined in the specification. The compounds are inhibitors of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family members (LOXL1, LOXL2, LOXL3, LOXL4) and are useful in therapy, particularly in the treatment of cancer. Also disclosed are LOX inhibitors for use in the treatment of a cancer associated with EGFR and biomarkers that predict responsiveness to a LOX inhibitor.

4.

发明申请
ANTIIFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES ABD 2-OXOTHIOPHENES COMPOUNDS 审中-公开

公开(公告)号：US20180105507A1

公开(公告)日：2018-04-19

申请号：US15789834

申请日：2017-10-20

Applicant: Avexxin AS

Inventor： Berit Johansen , Marcel Sanderberg , Inger-Reidun Aukrust , George Kokotos , Efrosini Barbayianni

IPC: C07D333/38 , C07D277/64 , A61K31/381 , A61K31/426 , C07D277/24 , A61K45/06 , C07D277/26 , C07D277/56 , A61K31/428

CPC classification number: C07D333/38 , A61K31/381 , A61K31/426 , A61K31/428 , A61K45/06 , C07D277/24 , C07D277/26 , C07D277/56 , C07D277/64

Abstract: A compound of formula (I) wherein X is O, C═O or S; Y is N or CH; R2 and R4 are each independently H, —(CH2)pCOOH, —(CH2)pCON(R5)2 or —(CH2)pCOOC1-6alkyl; or R2 and R4 together form a 6-membered phenyl ring fused to the five membered ring; each R1 is independently selected from H, halo (e.g. fluoro or chloro), C6-10aryl, C7-12arylalkyl, C2-12 alkenyl; OC1-12 alkyl, OC2-12 alkenyl or a C1-12 alkyl group; each R5 is H or C1-6 alkyl; each p is 0 to 3; n is 1 to 4; or a salt, ester, solvate, N-oxide, or prodrug thereof, e.g. a salt thereof

5.

发明申请
Novel Compound, Organic Cation Transporter 3 Detection Agent, And Organic Cation Transporter 3 Activity Inhibitor 有权
Title translation: 新型化合物，有机阳离子转运蛋白3检测剂和有机阳离子转运蛋白3活性抑制剂

公开(公告)号：US20160318886A1

公开(公告)日：2016-11-03

申请号：US14902005

申请日：2014-06-30

Applicant: SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.

Inventor： SUZUKI Nobuyuki , YAMASHITA Hidetoshi

IPC: C07D277/48 , C07D417/06 , C07D213/75 , C07D401/12 , C07D207/42 , C07D417/14 , C07D277/26 , C07D277/36 , C07D307/72 , C07D417/12 , C07C317/28

CPC classification number: C07D277/48 , C07C317/28 , C07C323/60 , C07D207/42 , C07D213/74 , C07D213/75 , C07D277/26 , C07D277/36 , C07D277/42 , C07D307/71 , C07D307/72 , C07D401/12 , C07D403/12 , C07D417/06 , C07D417/12 , C07D417/14

Abstract: [Problem] The present invention addresses the problem of providing a novel compound. The present invention also addresses the problem of providing an OCT3 detection agent or an OCT3 activity inhibitor, which comprises the novel compound.[Solution] A compound represented by formula (A), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. R1-R2-R3-R4 (A)

6.

发明申请
Thiazole Derivatives as Alpha 7 NACHR Modulators 审中-公开
Title translation: 噻唑衍生物作为Alpha 7 NACHR调制器

公开(公告)号：US20150299178A1

公开(公告)日：2015-10-22

申请号：US14439120

申请日：2013-11-11

Applicant: LUPIN LIMITED

Inventor： Neelima Sinha , Navnath Popat Karche , Anil Kashiram Hajare , Baban Rupaji Thube , Firoj Aftab Raje , Dnyaneshwar Changdeo Bhanage , Sudhakar Maruti Balgude , Venkata P. Palle , Rajender Kumar Kamboj

IPC: C07D417/06 , A61K45/06 , A61K31/4439 , A61K31/439 , C07D277/24 , A61K31/426

CPC classification number: C07D417/06 , A61K31/426 , A61K31/439 , A61K31/4439 , A61K45/06 , C07D277/24 , C07D277/26 , C07D277/46 , C07D277/56 , C07D417/04

Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5 and m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly α7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.

Abstract translation: 公开了式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和m如本文所述，作为烟碱乙酰胆碱受体，特别是α7亚型，其互变异构形式，其立体异构体，其药学上可接受的盐，其药物组合物及其与合适药物的组合。还公开了化合物的制备方法及其在治疗中的用途，特别是在诸如阿尔茨海默氏病，轻度认知障碍，老年痴呆等疾病的预防和治疗中。

7.

发明授权
Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests 有权
Title translation: 用于防治无脊椎动物害虫的氟化氧杂环或硫杂杂烷基烷硫醚衍生物

公开(公告)号：US09023874B2

公开(公告)日：2015-05-05

申请号：US13510197

申请日：2010-11-11

Applicant: Sebastian Soergel , Ralph Paulini , Steffen Gross , Carsten Beyer , Matthias Pohlman , Henricus Maria Martinus Bastiaans , Michael Rack , Deborah L. Culbertson , Douglas D. Anspaugh , Sarah Thompson , Vincent Salgado

Inventor： Sebastian Soergel , Ralph Paulini , Steffen Gross , Carsten Beyer , Matthias Pohlman , Henricus Maria Martinus Bastiaans , Michael Rack , Deborah L. Culbertson , Douglas D. Anspaugh , Sarah Thompson , Vincent Salgado

IPC: A01N43/824 , A01N43/08 , A01N43/22 , A01N43/40 , A01N43/46 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/62 , A01N43/647 , A01N43/66 , A01N43/713 , A01N43/72 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/325 , C07D209/12 , C07D209/10 , C07D213/32 , C07D231/12 , C07D233/66 , C07D235/12 , C07D237/08 , C07D239/20 , C07D249/08 , C07D251/16 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/26 , C07D285/12 , C07D307/40 , C07D307/38 , C07D307/79 , C07D307/80 , C07D333/18 , C07D333/54 , C07D333/56 , C07D213/34 , A01N43/10

CPC classification number: C07D285/12 , A01N43/08 , A01N43/10 , A01N43/22 , A01N43/40 , A01N43/46 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/62 , A01N43/647 , A01N43/66 , A01N43/713 , A01N43/72 , A01N43/78 , A01N43/80 , A01N43/82 , C07D207/325 , C07D209/10 , C07D209/12 , C07D213/32 , C07D213/34 , C07D233/66 , C07D235/12 , C07D237/08 , C07D239/20 , C07D249/08 , C07D251/16 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/26 , C07D307/38 , C07D307/40 , C07D307/79 , C07D307/80 , C07D333/18 , C07D333/54 , C07D333/56

Abstract: The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.

Abstract translation: 本发明涉及用于对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫的对映异构体或其兽医学上可接受的盐的烷基硫醚衍生物化合物。本发明还涉及通过使用这些化合物和植物繁殖材料以及包含所述化合物的农业和兽用组合物来控制无脊椎害虫的方法。其中U，R1，R2，R3U，X，n和p如说明书中所定义。

8.

发明授权
Pharmaceutical comprising PPAR agonist 有权
Title translation: 包含PPAR激动剂的药物

公开(公告)号：US08148389B2

公开(公告)日：2012-04-03

申请号：US12085548

申请日：2006-11-27

Applicant: Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue

Inventor： Yoshikuni Nakamura , Ikuko Hanano , Jun Inoue

IPC: A01N43/54 , A01N43/78 , A01N37/10

CPC classification number: C07D239/47 , A61K31/216 , A61K31/426 , A61K31/505 , C07D277/26

Abstract: An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as well as provide an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye.There are provided an agent for promoting proliferation of a meibomian gland epithelial cell or a corneal epithelial cell, containing a PPARα or δ agonist as an active ingredient, as well as an agent for treating an ocular disease such as meibomian gland dysfunction or evaporative dry eye, containing a PPARα or δ agonist as an active ingredient.

Abstract translation: 本发明的目的是提供一种用于促进睑板腺上皮细胞和角膜上皮细胞增殖的药剂，以及提供用于治疗诸如睑板腺功能障碍或蒸发干眼症的眼部疾病的药剂。提供了用于促进睑板腺上皮细胞或角膜上皮细胞的增殖的试剂，其含有PPARα或δ激动剂作为活性成分，以及用于治疗眼部疾病如睑板腺功能障碍或蒸发性干眼症的药剂，含有PPARα或δ激动剂作为活性成分。